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Effects of GnRH Agonist-Induced Ovarian Suppression on Calcium Homeostasis and Bone Metabolism in Premenstrual Women

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GnRH Analogues in Cancer and Human Reproduction

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Abstract

In 1940, Albright et al [1] first observed an association between estrogen deprivation and loss of bone mass. Bone loss may be attributed to an increase in the sensitivity of bone to the resorbing action of parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D3 or other bone-resorbing agents [2, 3], Higher values for calcium in serum and urinary excretion of calcium [4, 5] have been observed in postmenopausal women, supporting the theory of an increased bone resorption. The greatest loss of bone mass occurs during the first four to five years after the menopause [6] and affects predominantly trabecular bone [7, 8]. Estrogen replacement therapy prevents postmenopausal bone loss and attendant osteoporotic fractures [9–12], Any factor that irreversibly decreases bone mass in premenopausal women predisposes to the disease of osteoporosis.

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Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Städtische Kliniken, Darmstadt, Germany

    S. Waibel, Th. Bremen & G. Leyendecker

  2. Department of Internal Medicine I, University of Heidelberg, Germany

    H. W. Minne, S. H. Scharla, R. Shiffl, C. Wüster & R. Ziegler

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  1. S. Waibel
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  2. H. W. Minne
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  3. Th. Bremen
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  4. S. H. Scharla
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  5. R. Shiffl
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  6. C. Wüster
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  7. R. Ziegler
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Editor information

Editors and Affiliations

  1. Syntex Research, Institute of Biological Science, Palo Alto, CA, 94304, USA

    B. H. Vickery

  2. Institute of Endocrinology, Sheba Medical Center and Bar Ilan University, Remat Gan, 52621, Israel

    B. Lunenfeld

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© 1990 Kluwer Academic Publishers

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Waibel, S. et al. (1990). Effects of GnRH Agonist-Induced Ovarian Suppression on Calcium Homeostasis and Bone Metabolism in Premenstrual Women. In: Vickery, B.H., Lunenfeld, B. (eds) GnRH Analogues in Cancer and Human Reproduction. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0725-6_17

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  • DOI: https://doi.org/10.1007/978-94-009-0725-6_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6811-6

  • Online ISBN: 978-94-009-0725-6

  • eBook Packages: Springer Book Archive

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