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Physiologic Effects of a Gonadotropin Releasing Hormone Antagonist in Normal Women

  • Janet E. Hall
  • Todd D. Brodie
  • Tom M. Badger
  • Jean Rivier
  • Wylie Vale
  • P. Michael Conn
  • William F. CrowleyJr.

Abstract

Because of their unique ability to cause pituitary desensitization [1], agonist analogs of GnRH have been used successfully to block gonadotropin output in the therapy of hormone sensitive tumors [2, 3] and other sex-steroid dependent diseases such as endometriosis [4] and uterine leiomyoma [5], as well as in precocious puberty [6], However, the complexity of action of these agonist analogs limits their use as physiologic probes. Additionally, the initial agonist phase prior to desensitization is not optimal for therapeutic uses in certain settings [2, 3]. Pure antagonists to the action of GnRH have now been developed which block the effect of GnRH on gonadotropin release in pituitary cell cultures [7], perifused pituitary cell columns [8] and intact animals [7, 9, 10]. These GnRH antagonists have been shown to compete with GnRH for receptor binding [11–15], but to stimulate receptor internalization at a slower rate than GnRH or its super-agonist analogs and to be processed differently [8, 16, 17].

Keywords

Luteinizing Hormone Precocious Puberty GnRH Antagonist Luteinizing Hormone Secretion Early Follicular Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Janet E. Hall
    • 1
    • 2
    • 3
  • Todd D. Brodie
    • 1
    • 2
    • 3
  • Tom M. Badger
    • 1
    • 2
    • 3
  • Jean Rivier
    • 1
    • 2
    • 3
  • Wylie Vale
    • 1
    • 2
    • 3
  • P. Michael Conn
    • 1
    • 2
    • 3
  • William F. CrowleyJr.
    • 1
    • 2
    • 3
  1. 1.Reproductive Endocrine Unit and the Vincent Memorial Research Laboratories; the Departments of Medicine and GynecologyMassachusetts General HospitalBostonUSA
  2. 2.The Salk Institute for Biological StudiesLa JollaUSA
  3. 3.The Department of PharmacologyUniversity of Iowa College of MedicineIowa CityUSA

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