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Rationale, Indications and Management of GnRH Analogues an Ovulation Induction Protocols

  • B. Lunenfeld
  • V. Insler
  • E. Lunenfeld
  • G. Potashnik
  • J. Levy

Abstract

The ovulatory cycle is governed and accompanied by characteristic protein and steroid hormonal levels that are reflected by typical changes in the reproductive organs. To enable grouping, superimposition, recording and comparison of various parameters of the ovulatory cycle, to define and characterize abnormalities and to plan rational therapeutic approaches, its span is divided into several phases. Each phase reflects a characteristic, easily definable hormonal or organic change. Depending on the criteria on which the division is based, several different phases of the ovulatory cycle may be recognized. In the following discussion the simple division into follicular, ovulatory and luteal phases will be used.

Keywords

GnRH Agonist Follicular Development Ovulation Induction Ovulatory Cycle Dominant Follicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Greep, RP (1963). Histology, histochemistry and ultrastructure of adult ovary. In: Grady, HG and Smith, DE (eds.) “The Ovary”, p.48. (Baltimore: Williams & Wilkins Co.)Google Scholar
  2. 2.
    Hertz, R (1963). Pituitary independence of the prepubertal development of the ovary of the rat and rabbit and its pertinence of the hypoovarianism in women. In: Grady, HG and Smith, DE (eds.) “The Ovary”, p.48. (Baltimore: Williams & Wilkins Co.)Google Scholar
  3. 3.
    Lunenfeld, B and Eshkol, A (1970). Immunology of follicle stimulating hormone and luteinizing hormone. Vitamins & Hormones, 27, 131CrossRefGoogle Scholar
  4. 4.
    Gougeon, A (1985). Origin and growth of the preovulatory follicle(s) in spontaneous and stimulated cycles. In: Testart, J and Frydman, R. (eds.) “Human In Vitro Fertilization”; Inserm Symposium No.24, p.3. (Elsevier Science Publisher, B.V.)Google Scholar
  5. 5.
    Baker, TG (1982). Oogenesis and ovulation in germ cells and fertilization. In: Austin, CR and Short, RV (eds.) “Reproduction in Mammals” Vol.1, p.17 (Cambridge University Press)Google Scholar
  6. 6.
    diZerega, GS, Turner, CK, Stouffer, RL, and Hodgen, GO (1981). Suppression of follicle stimulating hormone dependent folliculogenesis during the prime ovarian cycles. J Clin Endocrinol Metab, 52, 451PubMedCrossRefGoogle Scholar
  7. 7.
    Ross, GT, Cargilie, CM, Lipsett, MB, Rayford, PL, Marshall, JR, Strott, CA, and Rodbard, D (1970). Pituitary and gonadal hormones in women during spontaneous and induced ovulatory cycles. Rec Prog Horm Res, 26, 1PubMedGoogle Scholar
  8. 8.
    Landgren, BM, Unden, AL, and Dicsfalusy, E (1980). Hormonal profile of the cycle in 68 normally menstruating women. Acta Endocrinol, 94. 89PubMedGoogle Scholar
  9. 9.
    Lewinthal, D, Furman, A, Blankstein, J and Lunenfeld, B (1986). Stable abnormalities in follicular development and hormonal profile in women with unexplained infertility. Fertil Steril, 46, 833PubMedGoogle Scholar
  10. 10.
    Insler, V and Lunenfeld, B (1974). Application of human gonadotropin for induction of ovulation. In: Campos da Paz, A, Hasegawa, T, Notake, Y and Hayashi, M (eds.) “Human Reproduction”, p.25. (Tokyo: Igaku Shoin)Google Scholar
  11. 11.
    Insler, V and Lunenfeld, B (1977). Human gonadotropins. In: Philip, EE, Barnes, J and Newton, M (eds.) “Scientific Foundation of Obstetrics and Gynaecology” p.629. (London: Heinemann)Google Scholar
  12. 12.
    Goodman, AL, Nixon, WE, Johnson, DL and Hodgen, GD (1977). Regulation of folliculogenesis in the rhesus monkey: selection of the dominant follicle. Endocrinology, 100, 155PubMedCrossRefGoogle Scholar
  13. 13.
    Hodgen GD (1982). The dominant follicle. Fertil Steril, 38, 281PubMedGoogle Scholar
  14. 14.
    Hodgen, GD, Goodman, AL, Stouffer, RL, Williams, RF, di Zerega, GS, Kreitman, OL, Marut, EL and Schenken, RS (1983). Selection of the dominant follicle and its ovum in the menstrual cycle. In: Baier, HM and Lindner, HR (eds.) “Fertilization of the Human Egg In Vitro”, p.57. (Springer, Berlin)Google Scholar
  15. 15.
    Blankstein, J, Mashiach, S, and Lunenfeld, B (1986) (eds.). “Ovulation Induction and In Vitro Fertilization”. (Year Book Medical Publishers, Inc)Google Scholar
  16. 16.
    Bringer, J, Hedon, B, Gibert, F, et al (1986). Induction de l’ovulation par injections pulsees de gonadoliberine (GnRH). In: Buvat, J and Bringer, J (eds.) “Induction et Stimulation de l’Ovulation”. (Paris: Doin Editeurs)Google Scholar
  17. 17.
    Lunenfeld E, Potashnik, G, and Insler, V (1986). Combined GnRH agonist and gonadotropin therapy in patients who failed to respond to previous ovulation inducting therapy. Israel Fertility Society Meeting, Abst, p.15Google Scholar
  18. 18.
    Diamond, MP (1988). Surgical aspects of infertility. In: Sciarra, JJ (ed.) “Gynecology and Obstetrics”, 5, p61Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • B. Lunenfeld
    • 1
  • V. Insler
    • 2
  • E. Lunenfeld
    • 2
  • G. Potashnik
    • 2
  • J. Levy
    • 2
  1. 1.Institute of EndocrinologySheba Medical Center and Bar-llan UniversityRamat GanIsrael
  2. 2.Division of Obstetrics and GynecologySoroka Medical Center and Ben-Gurion University of the NegevBeer-ShebaIsrael

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