Comparison of Buserelin to Danazol Therapy in Endometriosis

  • A. Lemay
  • HRPI buserelin protocol 310 study group


Although the etiology of endometriosis is not understood, it is known that the ectopic endometrial tissue is sensitive to the production of sex steroid hormones during the menstrual cycle. Endometriosis is rare before menarche and develops usually during the reproductive years. The importance of ovarian steroids in the development and maintenance of endometriosis is also demonstrated by the usual curative effect of oophorectomy and the spontaneous regression of the disease at menopause. Experimentally implanted endometriosis in castrated monkeys requires sex steroids for its maintenance [1].


GnRH Agonist Serum Estradiol Serum Estradiol Level Endometriotic Tissue Clinical Side Effect 
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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • A. Lemay
    • 1
    • 2
    • 3
  • HRPI buserelin protocol 310 study group
  1. 1.Endocrinology of ReproductionHospital Saint-Francoise D’AssiseCanada
  2. 2.Hoechst—Roussel Pharmaceuticals Inc.SomervilleUSA
  3. 3.Hoechst Canada Inc.MontrealCanada

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