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Acute Leukaemias

  • B. Frisch
  • R. Bartl
Part of the Current Histopathology book series (CUHI, volume 15)

Abstract

Traditionally, the diagnosis of acute leukaemia has been, and still is, based on peripheral blood counts and on routinely stained smears of blood and bone marrow aspirates1 (except in cases of a dry tap). Electron microscopy, cytogenetics, cytochemistry, presence of Auer rods, immunological (monoclonal antibodies) and enzyme markers are required for categorization and phen-otyping2–8. In some cases, especially those with some degree of differentiation, the type of leukaemia may be recognized in sections of the biopsies; for example erythroblastic, megakaryoblastic and monoblastic cell lines9.

Keywords

Bone Marrow Acute Myeloid Leukaemia Bone Marrow Biopsy Bone Marrow Infiltration Peripheral Blood Count 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bennett, J. M., Catavosky, D., Daniel, M. T., Flandrin, G., Galton, D. A. G., Gralnick, H. R. and Sultan, C. (1976). (French-American-British (FAB) Co-operative Group). Proposal for the classification of the acute leukaemias. Br. J. Haematol., 33, 451CrossRefGoogle Scholar
  2. 2.
    Bennett, J. M., Catovsky, D., Daniel, M. T., Flandrin, G., Galton, D. A. G., Gralnick, H. R. and Sultan, C. (1981). (FAB Co-operative Group). The morphological classification of acute lymphoblastic leukaemia. Concordance among observers and clinical correlations. Br. J. Haematol., 47, 553PubMedCrossRefGoogle Scholar
  3. 3.
    Meeting Report of the Second MIC Cooperative Study Group (1988). Leuven Belgium, 15–17 September 1986 on morphologic, immunologic and.cytogenetic (MIC) working classification of the acute myeloid leukaemias. Br. J. Haematol., 68, 487CrossRefGoogle Scholar
  4. 4.
    Groupe Français de Morphologie Hématologique (1987). French Registry of Acute Leukaemia and Myelodysplasic Syndromes. Age distribution and hemogram analysis of the 4496 cases recorded during 1982-1983 and classified according to FAB criteria. Cancer, 60, 1385CrossRefGoogle Scholar
  5. 5.
    Koike, T. (1984). Megakaryoblastic leukaemia: the characterization and identification of megakaryoblasts. Blood, 64, 683PubMedGoogle Scholar
  6. 6.
    Ming-jer Huang, Chin-Yang Li, Nichols, W. L, Ji-Hsiung Young and Katzmann, J. A. (1984). Acute leukaemia with megakaryocytic differentiaiton: a study of 1 2 cases identified immunocytochemically. Blood, 64, 427PubMedGoogle Scholar
  7. 7.
    Eriber, W. N., Breton-Gorius, J., Villeval, J. L, Oscier, D. G., Bai, Y. and Mason, Y. (1987). Detection of cells of megakaryocyte lineage in haematological malignancies by immunoalkaline phosphatase labelling cell smears with a panel of monoclonal antibodies. Br. J. Haematol., 65, 87PubMedCrossRefGoogle Scholar
  8. 8.
    Fialkow, P. J., Singer, J. W., Raskind, W. H., Adamson, Jacobson R. J. Bernstein, I. D. Dow, L. W. Najfeld V. and Veith R. (1987). Clonal development, stem-cell differentiation, and clinical remissions in acute nonlymphoblastic leukaemia. N. Engl. J. Med., 317, 466CrossRefGoogle Scholar
  9. 9.
    Janvier, M., Tobelem, G., Daniel, M. T., Bernheim, A., Marty, M. and Boiron, M. (1984). Acute monoblastic leukaemia. Scand. J. Haematol., 32, 385PubMedCrossRefGoogle Scholar
  10. 10.
    Howe, R. B., Bloomfield, C. D. and McKenna, R. W. (1982). Hypocellular acute leukaemia. Am. J. Med., 72, 391PubMedCrossRefGoogle Scholar
  11. 11.
    Maddox, A. M., Keating, M. J., Smith, T. L. et al. (1986). Prognostic factors for survival of 194 patients with low infiltrate leukaemia. Leukaemia Res., 10, 995CrossRefGoogle Scholar
  12. 12.
    Berdeaux, D. H., Glasser, I., Serokmann, R., Moon, T. and Durie, B. G. (1986). Hypoplastic acute leukaemia: review of 70 cases with multivariate regression analysis. Haematol. Oncol., 4, 291CrossRefGoogle Scholar
  13. 13.
    Manoharan, A., Horsley, R. and Pitney, W. R. (1979). The reticulin content of bone marrow in acute leukaemia in adults. Br. J. Haematol., 43, 185PubMedCrossRefGoogle Scholar
  14. 14.
    Oscier, D. G. and Stenvenson, J. C. (1988). Ectopic production of calcitonin and hypocalcemia in acute leukemia. Br. J. Haematol., 68, 265PubMedCrossRefGoogle Scholar
  15. 15.
    Schenkein, D. P., O’Neil, W. C, Shapiro, J. and Miller, K. B. (1986). Accelerated bone formation causing profound hypocalcemia in acute leukaemia. Ann. Intern. Med., 105, 375PubMedGoogle Scholar
  16. 16.
    Brito-Babapulle, F., Catovsky, D. and Galton, D. A. G. (1987). Clinical and laboratory features of de novo acute myeloid leukaemia and trilineage myelodysplasia. Br. J. Haematol., 66, 445PubMedCrossRefGoogle Scholar
  17. 17.
    Jinnai, I., Tomonaga, M., Kuriyama, K., Matsuo, T., Nonaka, H., Amenormori, Y., Yoshida, Y., Kusano, M., Tagawa, M. and Ichimaru, M. (1987). Dysmegakaryocytopoiesis in acute leukaemias: its predominance in myelomonocytic (M4) leukaemia and implication for poor response to chemotherapy. Br. J. Haematol., 66, 467PubMedCrossRefGoogle Scholar
  18. 18.
    Harrington, D. S., Peterson, C, Ness, M., Sanger, W., Smith, D. M. and Vaughan, W. (1988). Acute myelogenous leukaemia with eosinophilic differentiation and Trisomy-I. Am. J. Clin. Pathol., 90, 464PubMedGoogle Scholar
  19. 19.
    Vilter, R. W. and Wiltse, D. (1985). Preleukaemia and urticaria pigmentosa followed by acute myeloblastic leukaemia. Arch. Intern. Med., 145, 349PubMedCrossRefGoogle Scholar
  20. 20.
    Islam, A., Frisch, B. and Henderson, E. S. (1989). Plastic embedded core biopsy-A complementary approach to bone marrow aspiration in the diagnosis of acute myeloid leukaemia. J. Clin. Pathol., (In Press)Google Scholar
  21. 21.
    Islam, A. and Henderson, E. S. (1988). Bone marrow biopsy in acute myeloid leukaemia. Hematol. Rev., 2, 187Google Scholar
  22. 22.
    Lewis, S. M. and Szur, L. (1963). Malignant myelodysplastic myelosclerosis. Br. Med. J., II, 472Google Scholar
  23. 23.
    Mahl, G., Frisch, B., Bartl, R., Kager, K., Pappenberger, R., Schlag, R. and Burkhardt, R. (1984). Acute myelofibrosis: Only one extreme in the spectrum of ‘iopathic’ myelofibrosis. In Lennert, K. and Hubbner, K. (eds), Pathology of the Bone Marrow. Stuttgart: G. FischlerGoogle Scholar
  24. 24.
    Truong, L. D., Saleem, A. and Schwartz, M. R. (1984). Acute myelofibrosis. A report of four cases and review of the literature. Medicine, 63, 182PubMedCrossRefGoogle Scholar
  25. 25.
    Bernardeschi, P., Bonechi, I and Urbano, U. (1986). Acute malignant myelosclerosis. Evidence for a panmyelotic disturbance of cellular differentiation. Haematologica, 71, 493PubMedGoogle Scholar
  26. 26.
    Thiele, J., Krech, R., Wienhold, St., Simon, K. G., Zankovich, R. and Fischer, R. (1987). The use of the anti-factor VIM method on trephine biopsies of the bone marrow for the identification of immature and atypical megakaryocytes in myeloproliferative diseases and allied disorders. A morphometric study. Virchows Arch. B, 54, 89PubMedCrossRefGoogle Scholar
  27. 27.
    Beiske, K., Langholm, R., Godal, T. and Marton, P. F. (1986). T-zone lymphoma with predominance of “plasmacytoid T-cells” associated with myelomonocytic leukaemia-a distinct clinicopatho-logical entity. J. Pathol., 150, 247PubMedCrossRefGoogle Scholar
  28. 28.
    Mayumi, M., Tsutsui, T., Shirane, H., Mizue, H. and Mikawa, H. (1985). Erythroleukemia with myelofibrosis- Pediatric case report and discussion of possible stem cell origin of the disorder. Acta. Haematol. Jpn., 48, 1414Google Scholar
  29. 29.
    Zanke, B. W., Johnston, J. B. and Israels, L G. (1988). Erythemic myelosis in chronic lymphocytic leukaemia. Cancer, 62, 954PubMedCrossRefGoogle Scholar
  30. 30.
    Frisch, J., Bartl, R. and Chaichik, S. (1986). Therapy-induced myelodysplasia and secondary leukaemia. Scand. J. Haematol., 36(Suppl. 45), 38CrossRefGoogle Scholar
  31. 31.
    Lohrmann, H. P. (1984). The problem of permanent marrow damage after cytotoxic drug treatment. Oncology, 41, 180PubMedCrossRefGoogle Scholar
  32. 32.
    Islam, A., Catovsky, D., Goldman, J. M. and Galton, D.A. G. (1984). Bone marrow fibre content in acute myeloid leukaemia before and after treatment. J. Clin. Pathol., 37, 1259PubMedCrossRefGoogle Scholar
  33. 33.
    Brody, J. P., Krause, J. R. and Penchansky, L. (1985). Bone marrow response to chemotherapy in acute lymphocytic leukaemia and acute non-lymphocytic leukaemia. Scand. J. Haematol., 35, 240PubMedGoogle Scholar
  34. 34.
    Abrams, R. A., Lichter, A. S., Bromer, R. H., Minna, J. D., Cohen, M. H, and Deisseroth, A. B. (1985). The haematopoietic toxicity of regional radiation therapy. Correlations for combined modality therapy with systemic chemotherapy. Cancer, 55, 1429PubMedCrossRefGoogle Scholar
  35. 35.
    Testa, N. G., Hendry, J. H. and Molineux, G. (1985). Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy. Anti-Cancer Res., 5, 101Google Scholar
  36. 36.
    Islam, A. (1987). Pattern of bone marrow regeneration following chemotherapy for acute myeloid leukemia. J. Med., 18, 108PubMedGoogle Scholar
  37. 37.
    Sale, G. E. and Buckner, C. (1988). Pathology of bone marrow in transplant recipients. Hematol/Oncol. Clin. N. Am., 2, 735Google Scholar
  38. 38.
    Brito-Babapulle, F., Catovsky, D. and Galton, D. A. G. (1988). Myelodysplastic relapse of de novo acute myeloid leukaemia with trilineage myelodysplasia: a previously unrecognized correlation. Br. J. Haematol., 68, 411PubMedCrossRefGoogle Scholar
  39. 39.
    Rajantie, J., Sale, G. E., Deeg, H. J., Amos, D., Applebaum, F., Storb, R., Clift, R. A. and Buckner, C. D. (1986). Adverse effect of severe marrowfibrosis on hematologic recovery after chemoradiotherapy and allogenic bone marrow transplantation. Blood, 67, 1693PubMedGoogle Scholar

Copyright information

© B. Frisch and R. Bartl 1990

Authors and Affiliations

  • B. Frisch
    • 1
  • R. Bartl
    • 2
  1. 1.Institute of Haematology, Ichilov Hospital and Sackler Faculty of MedicineTel-Aviv UniversityIsrael
  2. 2.Bone Marrow Diagnosis Dept. of Internal Medicine “Innenstadt”University of MunichGermany

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