The Mononuclear Phagocyte System

  • B. Frisch
  • R. Bartl
Part of the Current Histopathology book series (CUHI, volume 15)


The designation ‘mononuclear phagocyte system’ has replaced the previous more comprehensive name of ‘reticuloendothelial system’, as this included non-phagocytic cells, such as fibroblast and endothelial cells, and cells which did not arise from the monocyte—macrophage progenitor, which also produces the granulocytic cell line. Recent studies have provided additional support for earlier conclusions on the derivation and function of monocytes and macrophages1,2. The bone marrow stem cells produce the committed progenitor which gives rise to the monoblast, promonocyte and monocyte in the bone marrow. The monocytes leave the bone marrow after their maturation, remain only a short time in the peripheral blood, migrate out into the tissues where they become macrophages.


Bone Marrow Acquire Immune Deficiency Syndrome Acquire Immunodeficiency Syndrome Human Immune Deficiency Virus Mononuclear Phagocyte System 
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Copyright information

© B. Frisch and R. Bartl 1990

Authors and Affiliations

  • B. Frisch
    • 1
  • R. Bartl
    • 2
  1. 1.Institute of Haematology, Ichilov Hospital and Sackler Faculty of MedicineTel-Aviv UniversityIsrael
  2. 2.Bone Marrow Diagnosis Dept. of Internal Medicine “Innenstadt”University of MunichGermany

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