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Survey of toxicological investigations of azapropazone

Abstract

The development of azapropazone more than twenty years ago was initiated by the discovery of compounds of the 1,2-dihydro-1,2,4-benzotriazine group with marked anti-inflammatory effect. The majority of those compounds proved, however, to the rather toxic in investigations carried out in the rat. The observation that fussing alkylmalonic acids at the 1,2 position of benzotriazine reduces the toxicity of these substances without diminishing their anti-inflammatory effect was therefore a decisive step forward

Keywords

Mefenamic Acid Niflumic Acid Single Oral Administration Toxicological Investigation Gastrointestinal Damage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • U. Jahn

There are no affiliations available

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