In 1981 Reitz and his co-workers at Stanford University successfully introduced heart—lung transplantation into clinical practice1, 2. Although the new form of transplantation was rapidly taken up by other centers, the pace of further development has been significantly slowed by the scarcity of suitable heart—lung donors. It was also soon appreciated that heart—lung recipients are at risk for a number of serious complications in the postoperative period, the most important of which are intrathoracic infections, particularly pneumonias3. These complications account for the fact that the healthy survival of heart—lung recipients is worse than other major organ transplant recipients3–5.


Transplant Recipient Chronic Rejection Lung Transplant Recipient Donor Lung Mycoplasma Hominis 
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  1. 1.
    Reitz, B.A., Wallwork, J.L., Hunt, S.A., Pennock, J.L., Billingham, M.E., Oyer, P.E., Stinson, E.B. and Shumway, N.E. (1982). Heart—lung transplantation. Successful therapy for patients with pulmonary vascular disease. N. Engl. J. Med., 306, 557PubMedCrossRefGoogle Scholar
  2. 2.
    Jamieson, S.W, Reitz, B.A., Oyer, P.E. et al. (1983). Combined heart and lung transplantation. Lancet, 1, 1130PubMedCrossRefGoogle Scholar
  3. 3.
    Griffith, B.P. (1987). Cardiopulmonary transplantation — growing pains. Int. J. Cardiol., 17, 119PubMedCrossRefGoogle Scholar
  4. 4.
    Morris, A.J.R. and Jamieson, S.W. (1987). Combined heart—lung transplantation for end-stage right ventricular failure. Cardiol. Clin., 17, 251Google Scholar
  5. 5.
    Thompson, M.E., Dummer, J.S., Paradis, I., Zeevi, A., Griffith, B.P. and Hardesty, R.L. (1987). Heart—lung transplantation — the courage to succeed. In Yu, P. (ed.) Progress in Cardiology. Vol. 16 (3). (Philadelphia: Lea and Febiger)Google Scholar
  6. 6.
    Pollard, R.B., Rand, K.H., Gamberg, P., Gallagher, J.G. and Merigan, T.C. (1982). Specific cell mediated immunity and infections with herpesvirus in cardiac transplant recipients. Am. J. Med., 73, 679PubMedCrossRefGoogle Scholar
  7. 7.
    Luft, B.J., Naot, Y., Araujo, F.G., Stinson, E.B. and Remington, J.S. (1983). Primary and reactivated toxoplasma infection in patients with cardiac transplants. Ann. Intern. Med., 99, 27PubMedGoogle Scholar
  8. 8.
    Wreghitt, T.G., Hakim, M., Cory-Pearce, R., English, T.A.H. and Wallwork, J. (1986). The impact of donor-transmitted CMV and Toxomplasma gondii disease in cardiac transplantation. Transplant. Proc., 18, 1375Google Scholar
  9. 9.
    Siegelman, S.S., Sinha, S.B.P. and Veith, F.J. (1973). Pulmonary reimplantation response. Ann. Surg., 177, 30CrossRefGoogle Scholar
  10. 10.
    Jamieson, S.W., Stinson, E.B., Oyer, P.E., Reitz, B.A., Baldwin, J., Modry, D., Dawkins, K., Theodore, J., Hunt, S. and Shumway, N.E (1984). Heart—lung transplantation for irreversible pulmonary hypertension. Ann. Thorac. Surg., 38, 554PubMedCrossRefGoogle Scholar
  11. 11.
    Mancini, M.C., Borovetz, H.S., Griffith, B.P. and Hardesty, R.L. (1985). Changes in lung vascular permeability after heart—lung transplantation. J. Surg. Res., 39, 305PubMedCrossRefGoogle Scholar
  12. 12.
    Dauber, J.H. and Zeevi, A. (1988). Lung transplantation: lessons learned about local immune function and pulmonary defense mechanisms. In Daniele, R.P. (ed.) Pulmonary Immunology, p. 625. (New York: McGraw Hill)Google Scholar
  13. 13.
    Mancini, M.C. and Tauxe, W.N. (1986). Assessment of pulmonary clearance in heart—lung transplant recipients using technetium99 minimicronized albumin colloid (MMAC). Am. Rev. Respir. Dis., 133, AllGoogle Scholar
  14. 14.
    Paradis, I.L., Marrari, M., Zeevi, A., Duquesnoy, R.J., Griffith, B.P., Hardesty, R.L. and Dauber, J.H. (1985). HLA phenotype of lung lavage cells following heart—lung transplantation. J. Heart Transplant., 4, 422PubMedGoogle Scholar
  15. 15.
    Fung, J.J., Zeevi, A., Kaufman, C., Paradis, I.L., Dauber, J.H., Hardesty, R.L., Griffith, B. and Duquesnoy, R.J. (1985). Interactions between lymphocytes and macrophages in heart—lung transplant recipients. Human Immunol., 14, 287CrossRefGoogle Scholar
  16. 16.
    Zeevi, A., Fung, J.J., Paradis, I.L., Dauber, J.H., Griffith, B.P, Hardesty, R.L. and Duquesnoy, R.J. (1985). Lymphocytes of bronchoalveolar lavage from heart—lung transplant recipients. J. Heart Transplant., 4, 417PubMedGoogle Scholar
  17. 17.
    Zeevi, A, Fung, J.J, Paradis, I.L, Gryzan, S, Dauber, J.H, Hardesty, R.L, Griffith, B, Trento, A, Saidman, S. and Duquesnoy, R.J. (1987). Bronchoalveolar macrophage—lymphocyte reactivity in heart—lung transplant recipients. Transplant. Proc., 19, 2537PubMedGoogle Scholar
  18. 18.
    Muggenburg, B.A, Bice, D.E, Haley, P.J, Mauderly, J.L, Dauber, J.J, Heron, K. and Griffith, B.P. (1987). Immune response in the transplanted canine lung. Am. Rev. Respir. Dis., 135, A103Google Scholar
  19. 19.
    Brooks, R.G, Hofflin, J.M, Jamieson, S.W, Stinson, E.B. and Remington, J.S. (1985). Infectious complications in heart—lung transplant recipients. Am. J. Med., 79, 412PubMedCrossRefGoogle Scholar
  20. 20.
    Dummer, J.S, Montero, C.G, Griffith, B.P, Hardesty, R.L, Paradis, I.L. and Ho, M. (1986). Infections in heart—lung transplant recipients. Transplantation, 41, 725PubMedCrossRefGoogle Scholar
  21. 21.
    Griffith, B.P, Kormos, R.L, Hardesty, R.L, Armitage, J.M. and Dummer, J.S. (1988). The artificial heart: infection-related morbidity and its effect on transplantation. Ann. Thorac. Surg., 45, 409PubMedCrossRefGoogle Scholar
  22. 22.
    Ho, M. (1982). Cytomegalovirus: Biology and Infection. (New York: Plenum Press)Google Scholar
  23. 23.
    Dummer, J.S, White, L.T, Ho, M, Griffith, B.P, Hardesty, R.L. and Bahnson, H.T. (1985). Morbidity of cytomegalovirus infection in recipients of heart or heart—lung transplants who received cyclosporine. J. Infect. Dis., 152, 1182PubMedCrossRefGoogle Scholar
  24. 24.
    Meyers, J.D, Flournoy, N. and Thomas, E.D. (1982). Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years’ experience. Rev. Infect. Dis., 4, 1119PubMedCrossRefGoogle Scholar
  25. 25.
    Shepp, D.H, Danliker, P.S, Miranda, P, Burnette, T.C, Cederberg, D.M, Kirk, L.E. and Meyers, J.D. (1985). Activity of 9-[2-hydroxyl-l-(hydroxymethyl) ethoxymethyl] guanine in the treatment of cytomegalovirus pneumonia. Ann. Intern. Med., 103, 368PubMedGoogle Scholar
  26. 26.
    Erice, A, Jordon, M.C, Chace, B.A, Fletcher, C, Chinnock, B.J. and Balfour, H.H. Jr. (1987). Ganciclovir treatment of cytomegalovirus disease in transplant recipients and other immunocompromised hosts. J. Am. Med. Assoc., 257, 3082CrossRefGoogle Scholar
  27. 27.
    Syndman, D.R, Werner, B.G, Heinze-Lacey, B, Berardi, V.P, Tilney, N.L, Kirkman, R.L, Milford, E.L, Cho, S.I, Bush H.L. Jr., Levey, A.S, Strom, T.B, Carpenter, C.B, Levey, R.H, Harmon, W.E, Zimmerman, C.E, Shapiro, M.E, Steinman, T, Logerfo, F, Idelson, B., Schroter, G.P.J, Levin, M.J, McIves, J, Leszczyrski, J. and Grady, G.F. (1987). Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal transplant recipients. N. Engl. J. Med., 317, 1049CrossRefGoogle Scholar
  28. 28.
    Ho, M, Miller, G, Atchison, R.W, Breinig, M.K, Dummer, J.S, Andeman, W, Starzl, T.E, Eastman, R, Griffith, B.P, Hardesty, R.L, Bahnson, H.T, Hakala, T.R. and Rosenthal, J.T. (1985). Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: The role of primary infection. J. Infect. Dis., 152, 876PubMedCrossRefGoogle Scholar
  29. 29.
    Beveridge, T, Krupp, P. and McKibbin, C. (1984). Lymphomas and lymphoproliferative lesions developing under cyclosporine therapy (Letter). Lancet, 1, 788PubMedCrossRefGoogle Scholar
  30. 30.
    Hanto, D, Frizzera, G, Gajl-Peczalska, K. and Simmons, R. (1985). Epstein—Barr virus, immunodeficiency and B-cell lymphoproliferation. Transplantation, 39, 461PubMedCrossRefGoogle Scholar
  31. 31.
    Starzl, T.E, Nalesnik, M.A., Porter, K.A, Ho, M, Iwatsuki, S, Griffith, B.P, Rosenthal, J.T, Hakala, T.R, Shaw, B.W. Jr., Hardesty, R.L. et al. (1984). Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporine-steroid therapy. Lancet, 1, 583PubMedCrossRefGoogle Scholar
  32. 32.
    Allen, M.D, Burke, C.M, McGregor, C.G.A, Baldwin, J.C, Jamieson, S.W. and Theodore, J. (1986). Steroid-responsive bronchiolitis after human heart—lung transplantation. J. Thorac. Cardiovasc. Surg., 92, 449PubMedGoogle Scholar
  33. 33.
    Dummer, J.S, Bahnson, H.T, Griffith, B.P, Hardesty, R.L, Thompson, M.E. and Ho, M. (1983). Infections in patients on cyclosporine and prednisone following cardiac transplantation. Transplant. Proc., 15, 2779Google Scholar
  34. 34.
    Dummer, J.S, Ho, M, McMahon, D.K, Griffith, B.P, Hardesty, R.L, Trento, A. and Bahnson, H.T. (1987). Infectious complications in heart and heart—lung transplant recipients. Proceedings of the 1st European Conference on Transplantation, Venice, Italy, March 1987Google Scholar
  35. 35.
    Steffenson, D.O., Dummer, J.S, Granick, M.S., Pasculle, A.W, Griffith, B.P. and Cassell, G.H. (1987). Sternotomy infections with Mycoplasma hominis. Ann. Intern. Med., 106, 204PubMedGoogle Scholar
  36. 36.
    Bygdeman, S.M. and Mardh, P.A. (1984). Antimicrobial susceptibility and susceptibility testing of Mycoplasma hominis. Sex. Trans. Dis., 11, 366CrossRefGoogle Scholar
  37. 37.
    Kenny, T, Hooten, M. and Roberts, M.C. (1987). Sensitivities of Mycoplasma hominis and Ureaplasma urealyticum to quinolones. Abstracts of the International Conference on Antimicrobial Agents and Chemotherapy, New YorkGoogle Scholar
  38. 38.
    Griffith, B.P, Hardesty, R.L, Trento, A. and Bahnson, H.T. (1985). Asynchronous rejection of heart and lungs following cardiopulmonary transplantation. Ann. Thorac. Surg., 40, 488PubMedCrossRefGoogle Scholar
  39. 39.
    Griffith, B.P, Durham, S.J, Hardesty, R.L, Trento, A. and Paradis, I.L. (1987). Acute rejection of the heart—lung allograft and methods of its detection. Transplant. Proc., 19, 2527PubMedGoogle Scholar
  40. 40.
    Novitzky, D, Cooper, D.K.C, Wicomb, W.N, Rose, A.G. and Reichart, R. (1985). Transplantation of the heart and both lungs. S. Afr. Med. J., 67, 575PubMedGoogle Scholar
  41. 41.
    Yousem, S.A., Burke, C.M. and Billingham, M.E. (1985). Pathologic pulmonary alterations in long-term human heart—lung transplantation. Hum. Pathol, 16, 911PubMedCrossRefGoogle Scholar
  42. 42.
    Theodore, J, Jamieson, S.W, Burke, C.M, Reitz, B.A, Stinson, E.B, Van Kessel, A, Dawkins, K.D, Herran, J.J, Oyer, P.E, Hunt, S.A., Shumway, N.E. and Robin, E.D. (1984). Physiologic aspects of human heart—lung transplantation. Chest, 86, 349PubMedCrossRefGoogle Scholar
  43. 43.
    Burke, C.M, Theodore, J, Dawkins, K.D, Yousem, S.A., Blank, N, Billingham, M.E, Van Kessel, A, Jamieson, S.W, Oyer, P.E, Baldwin, J.C, Stinson, E.B, Shumway, N.E. and Robin, E.D. (1984). Post-transplant obliterative bronchiolitis and other late lung sequelae in human heart—lung transplantation. Chest, 86, 824PubMedCrossRefGoogle Scholar
  44. 44.
    Gryzan, S, Paradis, I.L, Zeevi, A. et al. (1988). Unexpectedly high incidence of Pneumocystis carinii infection after lung—heart transplantation: implications for lung defense and allograft survival. Am. Rev. Respir. Dis., 137, 1268PubMedGoogle Scholar

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© Kluwer Academic Publishers 1990

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  • J. S. Dummer

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