Detection and assessment of the severity of coronary artery disease by dipyridamole echocardiography test

  • Eugenio Picano
  • Fabio Lattanzi
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 113)

Abstract

Dipyridamole is a potent coronary arteriolar vasodilator that has been employed in combination with thallium-201 imaging for the detection of coronary artery disease. Since a coronary stenosis may significantly reduce the regional coronary reserve without inducing ischemia, the presence of coronary artery disease can be documented by the different uptake of a flow tracer, such as thallium-201. Theoretically, myocardial ischemia is not required for the dipyridamole-thallium test to be positive. However, dipyridamole infusion can also induce myocardial ischemia in the presence of a coronary obstruction. This has been shown by a large amount of experimental and clinical evidence [1]. At a dosage of 0.75 mg/kg over 10 min, the electrocardiogram (ECG)-dipyridamole stress test has been proposed for the diagnosis of coronary artery disease, with a diagnostic accuracy comparable to the exercise stress test and an overall sensitivity (ECG changes and/or anginal pain) of about 80% (for a review, see ref [1]).

Keywords

Coronary Stenosis Exercise Stress Test Isosorbide Dinitrate Dipyridamole Infusion Coronary Reserve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Eugenio Picano
  • Fabio Lattanzi

There are no affiliations available

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