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Neurofibromatosis or von Recklinghausen’s disease

  • J. J. De Laey
  • M. Hanssens
Part of the Monographs in Ophthalmology book series (MIOP, volume 14)

Abstract

At least four different forms of neurofibromatosis can be considered [76]:
  1. 1.

    von Recklinghausen’s neurofibromatosis

     
  2. 2.

    bilateral acoustic neurofibromatosis, where the cutaneous lesions, typical of the first form, are often lacking

     
  3. 3.

    segmental neurofibromatosis, where the typical lesions are confined to one segment of the body and

     
  4. 4.

    cutaneous neurofibromatosis, which is probably to be considered as a ‘forme fruste’ of generalized neurofibromatosis.

     

Keywords

Optic Nerve Tuberous Sclerosis Central Retinal Vein Occlusion Plexiform Neurofibroma Congenital Glaucoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Agoston I (1968): Beidseitige symmetrische Sektorenförmige Pigmentveränderung der Netzhaut bei den Recklinghauschen Neurofibromatosis. Acta Ophthalmol, 46: 41–48.Google Scholar
  2. 2.
    Allende F P (1945): Diffuse neurofibromatosis (von Recklinghausen’s disease) involving the bulbar conjunctiva. Report of a case with lesions of the skeletal system and skin, bodily asymmetry and intracranial involvement. Arch Ophthalmol, 33: 110–115.Google Scholar
  3. 3.
    Archer D B and Nevin N C (1977): The phakomatoses. I. Neurofibromatosis — von Recklinghausen’s disease in Krill’s Hereditary retinal and choroidal diseases, Harper and Row Publishers, vol. 2, 1193–1218.Google Scholar
  4. 4.
    Barker D, Wright E, Nguyen K, Cannon L, Fain P, Goldgar D, Bishop D T, Carey J, Baty B, Kiu Lin J, Willard H, Waye J S, Greig G, Leinwand L, Nakamura Y, O’Connell P, Leppert M, Lalouel J M, White R, and Skolnick M (1987): Gene for von Recklinghausen’s neurofibromatosis is in the pericentrometric region of chromosome 17. Science, 236: 1100–1102.PubMedGoogle Scholar
  5. 5.
    Beck RW and Hanno R (1986): The Phakomatose. Int Ophthalmol Clin, 25: 97–116.Google Scholar
  6. 6.
    Bengisu U, Tahsinoglu M, and Toker G (1973): La neurofibromatose associée au choristome cartilagineux de l’épisclère. Ann Oculist, 206: 401–403.Google Scholar
  7. 7.
    Bergin D J, Johnson T E, Spencer W H and McCord C D (1988): Gangliomata of the optic nerve. Am J Ophthalmol, 105: 146–149.PubMedGoogle Scholar
  8. 8.
    Bickler-Bluth M E, Custer P L, and Smith M E (1988): Neurilemmoma as a presenting feature of neurofibromatosis. Arch Ophthalmol, 106: 665–667.PubMedGoogle Scholar
  9. 9.
    Bielschowsky M (1914): Ueber tuberöse Sklerose und ihre Beziehungen zur Reckling-hausensche Krankheit. Z Ges Neurol Psychiatr, 26: 133–155.Google Scholar
  10. 10.
    Bloch F J (1948): Retinal tumor associated with neurofibromatosis (von Recklinghausen’s disease). Report of a case. Arch Ophthalmol, 40: 433–437.Google Scholar
  11. 11.
    Bolande R P (1974): The neurocristopathies. A unifying concept of disease arising in neural crest maldevelopment. Hum Pathology, 5: 409–429.Google Scholar
  12. 12.
    Boles W M, Naugle T C and Samson C L M (1958): Glioma of the optic nerve. Report of a case arising from the optic disc. Arch Ophthalmol, 59: 229–231.Google Scholar
  13. 13.
    Bonamour G and Leopold (1958): Cataracte de type syndermatotique et maladie de Recklinghausen. Bull Soc Ophtalmol Fr, 58: 592–593.Google Scholar
  14. 14.
    Brini A (1986): La neurofibromatose, l’oeil et ses annexes. Une synthèse. Bull Soc Ophtalmol Fr, 86: 335–337.PubMedGoogle Scholar
  15. 15.
    Bronner A, Roth A, and Fritz B (1959): Lésions oculaires au cours d’une neurofibromatose de von Recklinghausen. Bull Soc Ophtalmol Fr, 11: 723–729.Google Scholar
  16. 16.
    Brownstein S, and Little J M (1983): Ocular neurofibromatosis. Ophthalmology, 91: 1595–1599.Google Scholar
  17. 17.
    Bullock J D, and Bartley G B (1986): Dynamic proptosis. Am J Ophthalmol, 102: 104–110.PubMedGoogle Scholar
  18. 18.
    Callender G R, and Thigpen C A (1930): Two neurofibromas in one eye. Am J Ophthalmol 13: 121–124.Google Scholar
  19. 19.
    Cernea P, and Dobrescu G (1973): Mélanome malin uvéal, manifestation de la maladie de Recklinghausen. Ophthalmologica, 166: 161–171.PubMedGoogle Scholar
  20. 20.
    Charleux J (1960): Les manifestations palpébrales et orbitaires de la neurofibromatose de Recklinghausen. Ann Oculist, 193: 930–962.Google Scholar
  21. 21.
    Cibis G W, Whittaker C K, and Wood WE (1985): Intraocular extension of optic nerve meningioma in a case of neurofibromatosis. Arch Ophthalmol, 103: 404–406.PubMedGoogle Scholar
  22. 22.
    Cotlier E (1977): Café au lait spots of the fundus in neurofibromatosis. Arch Ophthalmol, 95: 1990–1992.PubMedGoogle Scholar
  23. 23.
    Crowe F W, Schull W J, and Neel J V (1956): A clinical, pathological and genetic study of multiple neurofibromatosis Charles C. Thomas (ed.): Springfield (III).Google Scholar
  24. 24.
    Curatolo P, and Cusmai R (1987): Optic glioma in children with neurofibromatosis. Lancet, 1: 1140.PubMedGoogle Scholar
  25. 25.
    Davis F A (1939): Plexiform neurofibromatosis (Recklinghausen’s disease) of orbit and globe with associated glioma of the optic nerve and brain. Report of a case. Arch Ophthalmol, 22: 761–791.Google Scholar
  26. 26.
    Davis F A (1940): Primary tumors of the optic nerve (a phenomenon of Recklinghausen’s disease). A clinical and pathologic study with a report of five cases and a review of the literature. Arch Ophthalmol, 23: 735–821, 957–1018.Google Scholar
  27. 27.
    Fledelius H, and Eldrup Jorgensen P (1977): Optic nerve glioma and phaeoehromocytoma associated with von Recklinghausen’s disease: a case report. Br J Ophthalmol, 61: 240–243.PubMedGoogle Scholar
  28. 28.
    Font R L, and Ferry A P (1972): The phakomatoses. Int Ophthalmol Clin, 12: 1–50.PubMedGoogle Scholar
  29. 29.
    Francois J (1948): Les manifestations oculaires de la maladie de Recklinghausen. Ann Oculist, 181: 753–791.Google Scholar
  30. 30.
    Francois J (1972): A general introduction. in Handbook of clinical neurology, P J Vinken and G W Bruyn, vol. 14. The phakomotoses, North Holland Publishing C°, Amsterdam, 1–18.Google Scholar
  31. 31.
    Francois J, Hanssens M, and Evens L (1972): Ganglioneurome mélanique de la choroïde. Bull Soc Belge Ophthalmol, 162: 858–867.Google Scholar
  32. 32.
    Francois J, and Katz C (1961): Association homolatérale d’hydrophtalmie, de névrome plexiforme de la paupière supérieure et d’hémihypertrophie faciale dans la maladie de Recklinghausen. Ophthalmologica, 142: 549–571.PubMedGoogle Scholar
  33. 33.
    Francois J, Verriest G, and Deblond R (1963): Gliome du chiasma, manifestation d’une neurofibromatose de Recklinghausen. Acta Neurol Belg, 63: 545–550.PubMedGoogle Scholar
  34. 34.
    Freedman S F, Einer V M, Donev I, Gunta R, and Albert D M (1988): Intra-ocular neurilemmoma arising from the posterior ciliary nerve in neurofibromatosis. Pathologic findings. Ophthalmology, 95: 1559–1564.PubMedGoogle Scholar
  35. 35.
    Freeman A G (1987): Proptosis and neurofibromatosis. Lancet 1032–1033.1032–1033Google Scholar
  36. 36.
    Freeman D (1934): Neurofibroma of the choroid. Arch Ophthalmol, 11: 641–645.Google Scholar
  37. 37.
    Frenkel M (1967): Retinal angiomatosis in a patient with neurofibromatosis. Am J Ophthalmol, 63: 804–808.PubMedGoogle Scholar
  38. 38.
    Frisen L, Hoyt W F, and Trengroth B M (1973): Optociliary veins, disc pallor and visual loss: a triad of signs indicating spheno-orbital meningioma. Acta Ophthalmol, 51: 241–249.Google Scholar
  39. 39.
    Gartner S (1940): Malignant melanoma of the choroid and von Recklinghausen’s disease. Am J Ophthalmol, 23: 73–78.Google Scholar
  40. 40.
    Gass J D M (1974): Differential diagnosis of intraocular tumors. A stereoscopic presentation. The C V Mosby C°, St. Louis, 22–23.Google Scholar
  41. 41.
    Gasteiger (1938): Ueber seltene Augenveränderungen bei Neurofibromatose. Ztschr Augenheilk, 95: 167–168.Google Scholar
  42. 42.
    Gilly J P, Leguellec M, Cotineau J and Sorato M (1975): Les tumeurs primitives de la papille au cours de la neurofibromatose de Recklinghausen. Ann Oculist, 208: 13–28.Google Scholar
  43. 43.
    Goldmann H, and Grunthal E (1941): Ueber einen Tumor des Sehnerven und seiner Leptomeningen bei Recklinghausenscher Krankheit. Ophthalmologica, 102: 79–92.Google Scholar
  44. 44.
    Goldsmith J (1949): Neurofibromatosis associated with tumors of the optic papilla. Report of a case. Arch Ophthalmol, 41: 718–729.Google Scholar
  45. 45.
    Goldstein I, and Wexler D (1930): Melanosis uveae and melanoma of the iris in neurofibromatosis (Recklinghausen). Arch Ophthalmol, 3: 288–296.Google Scholar
  46. 46.
    Goldstein I and Wexler D (1932): Spongioneuroblastoma of the optic nerve in neurofibromatosis (Recklinghausen). Arch Ophthalmol, 7: 259–267.Google Scholar
  47. 47.
    Grant W M, and Walton D S (1968): Distinctive gonioscopic findings in glaucoma due to neurofibromatosis. Arch Ophthalmol, 79: 127–134.PubMedGoogle Scholar
  48. 48.
    Gurland J E, Tenner M, Hornblass A, and Wolintz A H (1976): Orbital neurofibromatosis: involvement of the orbital floor. Arch Ophthalmol, 94: 1723–1725.PubMedGoogle Scholar
  49. 49.
    Haik B G, Saint Louis L, Bierly J, Smith M E, Abramson D A, Ellsworth R M, and Wall M (1987): Magnetic resonance imaging in the evaluation of optic nerve gliomas. Ophthalmology, 94: 709–717.PubMedGoogle Scholar
  50. 50.
    Hales R H (1963): Glioma of the optic disc. Arch Ophthalmol, 70: 648–650.PubMedGoogle Scholar
  51. 51.
    Hanssens M (1973): Recklinghausen’s disease with ocular involvement. Presented at EOPS’ 12th annual meeting, Dublin.Google Scholar
  52. 52.
    Hartemann P, Dureux J B, and Martin J (1957): Considérations ophthalmologiques et électro-encéphalographiques sur 31 observations de sclérose tubéreuse de Bourneville et de neurofibromatose de Recklinghausen. Rev Oto-Neuro-Ophtalmol, 29: 216–225.Google Scholar
  53. 53.
    Hasanreisoglu B, Or M, and Akbatur H (1988): Neurofibromatosis associated with retinoblastoma: case report. Br J Ophthalmol, 72: 139–141.PubMedGoogle Scholar
  54. 54.
    Hogan M J and Zimmerman L E (1962): Ophthalmic Pathology. 2nd Edition, W B Saunders, Philadelphia, 443–530.Google Scholar
  55. 55.
    Holman R E, Grimson B S, and Drayer B P (1985): Magnetic resonance imaging of optic gliomas. Am J Ophthalmol, 100: 596–601.PubMedGoogle Scholar
  56. 56.
    Hoyt W F, and Baghdassarian S A (1969): Optic glioma of childhood. Natural history and rationale to conservative treatment. Br J Ophthalmol, 53: 793–798.PubMedGoogle Scholar
  57. 57.
    Humble R M (1967): Phaeochromocytoma, neurofibromatosis and pregnancy. Anaestesia, 22: 296–303.Google Scholar
  58. 58.
    Huson S, Jones D, and Beck L (1987): Ophthalmic manifestations of neurofibromatosis. Br J Ophthalmol, 74: 235–238.Google Scholar
  59. 59.
    Insler M S, Helm C, and Napoli S (1985): Conjunctival hamartoma in neurofibromatosis. Am J Ophthalmol, 99: 731–733.PubMedGoogle Scholar
  60. 60.
    Kilchhofer A, Boltshauser E, and Flueler U (1986): Aspekt und Inzidenz der Irisha-martome bei Neurofibromatosis von Recklinghausen. Klin Mbl Augenheilk, 188: 416–417.Google Scholar
  61. 61.
    Klein R M, and Glassman L (1985): Neurofibromatosis of the choroid. Am J Ophthalmol, 99: 367–368.PubMedGoogle Scholar
  62. 62.
    Kobrin J L, Blodi F C, and Weingeist T A (1979): Ocular and orbital manifestations of neurofibromatosis. Survey Ophthalmol, 24: 45–51.Google Scholar
  63. 63.
    Koch G (1972): Genetic aspects of the phakomatoses. in Handbook of Clinical Neurology, P J Vinken, and G W Bruyn, vol. 14. The phakomatoses, North Holland Publishing C°, Amsterdam, 488–561.Google Scholar
  64. 64.
    Krohel G B, Rosenberg P M, Wright J E, and Smith R S (1985): Localized orbital neurofibromatosis. Am J Ophthalmol, 100: 458–464.PubMedGoogle Scholar
  65. 65.
    Kurosawa A and Kurosawa H (1982): Ovoid bodies in choroidal neurofibromatosis. Arch Ophthalmol, 100: 1939–1941.PubMedGoogle Scholar
  66. 66.
    La Piana F G (1977): Sectorial retinal pigmentation in neurofibromatosis. Ann Ophthalmol 9: 413–422.PubMedGoogle Scholar
  67. 67.
    Lewis R A, and Riccardi V M (1981): Von Recklinghausen neurofibromatosis. Incidence of iris hamartomas. Ophthalmology, 88: 348–354.PubMedGoogle Scholar
  68. 68.
    Lewis R A, Gerson L P, Axelson K A Riccardi V M, and Whitford R P (1984): Von Recklinghausen neurofibromatosis. II. Incidence of optic gliomata. Ophthalmology, 91: 929–935.PubMedGoogle Scholar
  69. 69.
    Lisch K (1937): Ueber Beteiligung der Augen, insbezondere das Vorkommen von Irisknötchen bei der Neurofibromatose (Recklinghausen). Ztschr Augenheilk, 93: 137–143.Google Scholar
  70. 70.
    Lloyd L A (1974): Gliomas of the optic nerve and chiasm in childhood. Trans Am Ophthalmol Soc, 71: 488–535.Google Scholar
  71. 71.
    Mans (1927): Neurofibromatose des Auges. Klin Mbl Augenheilk, 79: 548.Google Scholar
  72. 72.
    Manschot W A (1954): Primary tumours of the optic nerve in von Recklinghausen’s disease. Br J Ophthalmol, 38: 285–289.PubMedGoogle Scholar
  73. 73.
    Martyn L J and Knox D L (1972): Glial hamartoma of the retina in generalized neurofibromatoses. Von Recklinghausen’s disease. Br J Ophthalmol, 56: 487–491.PubMedGoogle Scholar
  74. 74.
    Meeker L H (1936): Plexiform neuroma of the choroid in a non-buphthalmic eye. Arch Ophthalmol, 16: 152.Google Scholar
  75. 75.
    Miller N R (1975): Optic nerve glioma and cerebellar astrocytoma in a patient with von Recklinghausen’s neurofibromatosis. Am J Ophthalmol, 79: 582–588.PubMedGoogle Scholar
  76. 76.
    Miller N R (1988): Neurofibromatosis. in Clinical Neuro-ophthalmology, Walsh and Hoyt, 4th edition, vol. 3. 1747–1765.Google Scholar
  77. 77.
    Musger A (1972): Dermatological aspects of the phakomatoses. in Handbook of clinical Neurology, P J Vinken and G W Bruyn, vol. 14, The phakomatoses, North Holland Publishing C°, Amsterdam, 562–618.Google Scholar
  78. 78.
    Nitsch M (1929): Neurofibromatose des Auges. Ztschr Augenheilk, 69: 117–143.Google Scholar
  79. 79.
    Nordmann J, and Brini A (1970): Von Recklinghausen’s disease and melanoma of the uvea. Br J Ophthalmol, 54: 641–648.PubMedGoogle Scholar
  80. 80.
    Paufique L, Etienne R, and Charleux J (1956): Exophtalmie pulsatile par malformation orbitaire dans la neurofibromatose de von Recklinghausen. Bull Soc Fr Ophtalmol, 69: 203–214.Google Scholar
  81. 81.
    Perry H D, and Font R L (1982): Iris nodules in von Recklinghausen’s neurofibromatosis. Electron microscopic confirmation of their melanocytic origin. Arch Ophthalmol, 100: 1635–1640.PubMedGoogle Scholar
  82. 82.
    Pieck C F M (1936): Ein Fall von Neurinoma Retinae. Von Graefe’s Arch Ophthalmol, 135: 451–461.Google Scholar
  83. 83.
    Politi F, Sachs R, and Barishak R (1978): Neurofibromatosis and congenital glaucoma. A case report. Ophthalmologica, 176: 155–159.Google Scholar
  84. 84.
    Pollet-de Lille and Pollet J (1953): Deux cas de thrombose de la veine ophtalmique chez deux jumelles atteintes de maladie de Recklinghausen. Bull Soc Fr Ophtalmol, 53: 286–288.Google Scholar
  85. 85.
    Riley F C, and Campbell R J (1979): Double phakomatosis. Arch Ophthalmol, 97: 518–520.PubMedGoogle Scholar
  86. 86.
    Robson S, Blackwood W, and Cookson H A (1941): Case of von Recklinghausen’s disease with diffuse neurofibromatosis of choroid. Br J Ophthalmol, 25: 431–442.PubMedGoogle Scholar
  87. 87.
    Rush J A, Younge B R, Campbell R J, and MacCarty C S (1982): Optic glioma: long-term follow-up of 85 histopathologically verified cases. Ophthalmology, 89: 1213–1219.PubMedGoogle Scholar
  88. 88.
    Saran N, and Winter F C (1967): Bilateral gliomas of the optic disc associated with neurofibromatosis. Am J Ophthalmol, 64: 607–612.PubMedGoogle Scholar
  89. 89.
    Savino P J, Glaser J S, and Luxenberg M N (1977): Pulsating enophthalmos and choroidal hamartomas: two rare stigmata of neurofibromatosis. Br J Ophthalmol, 61: 483–488.PubMedGoogle Scholar
  90. 90.
    Schmoger E (1956): Myopia and von Recklinghausen’s neurofibromatosis. Von Graefe’s Arch Ophthalmol, 157: 260–277.Google Scholar
  91. 91.
    Shapland C D, and Greenfield J G (1935): A case of neurofibromatosis with meningeal tumour involving the left optic nerve. Trans Ophthalmol Soc U.K., 55: 257–279.Google Scholar
  92. 92.
    Sheehan B (1952): Optic atrophy with altitudinal hemianopia in neurofibromatosis. Br J Ophthalmol, 36: 506–510.PubMedGoogle Scholar
  93. 93.
    Shokeir M H K (1970): Von Hippel-Lindau syndrome: a report on three kindreds. J Med Genet, 7: 155–157.PubMedGoogle Scholar
  94. 94.
    Spencer W H, and Borit A (1967): Diffuse hyperplasia of the optic nerve in von Recklinghausen’s disease. Am J Ophthalmol, 64: 638–642.PubMedGoogle Scholar
  95. 95.
    Stallard H B (1938): A case of intra-ocular neuroma (von Recklinghausen’s disease) of the left optic nerve head. Br J Ophthalmol, 22: 11–18.PubMedGoogle Scholar
  96. 96.
    Stern J, Jakobiec F A, and Housepian E M (1980): The architecture of optic nerve gliomas with and without neurofibromatosis. Arch Ophthalmol, 98: 505–511.PubMedGoogle Scholar
  97. 97.
    Stough J T (1937): Intraocular neurofibroma. Report of a case. Arch Ophthalmol, 18: 540–546.Google Scholar
  98. 98.
    Szekler R (1953): Ein Uvealsarkom bei einem Mitglied einer Familie mit Recklinghau-senscher Krankheit. Ophthalmologica, 126: 248–251.PubMedGoogle Scholar
  99. 99.
    Thomas J V, Schwartz P L, and Gragoudas E S (1978): Von Hippel’s disease in association with von Recklinghausen’s neurofibromatosis. Br J Ophthalmol, 62: 604–608.PubMedGoogle Scholar
  100. 100.
    Tishler P V (1975): A family with coexistent von Recklinghausen’s neurofibromatosis and von Hippel-Lindau’s disease. Diseases possibly derived from a common gene. Neurology, 25: 840–844.PubMedGoogle Scholar
  101. 101.
    Trincao R, Cunha-Vaz J G, and Pires J M (1973): Astrocytic hamartoma of the optic disc in localized ocular neurofibromatosis (von Recklinghausen’s disease). Ophthalmologica, 167: 465–469.PubMedGoogle Scholar
  102. 102.
    Trueman R H, and Rubin I E (1953): Tumor of the optic disc associated with neurofibromatosis. Presentation of a case. Arch Ophthalmol, 50: 469–474.Google Scholar
  103. 103.
    Turek E, Raistrick E R, and Hart C D (1977): Retinal tumours in neurofibromatosis. Can J Ophthalmol, 12: 68–70.PubMedGoogle Scholar
  104. 104.
    Turpin R, Saraux M, Caille B, Grignon J, and Chome J (1963): La forme oculo-faciale bilatérale de la neurofibromatose faciale. Ann Ocul, 776–789.Google Scholar
  105. 105.
    Ufermann K (1972): Doppelseitige Augenbeteiligung bei der Neurofibromatose von Recklinghausen. Klin Mbl Augenheilk, 161: 305–308.PubMedGoogle Scholar
  106. 106.
    Ulbright T M, Fulling K H, and Helveston E M (1984): Astrocytic tumors of the retina. Differentiation of sporadic tumors from phakomatosis-associated tumors. Arch Pathol Lab Med, 108: 160–163.PubMedGoogle Scholar
  107. 107.
    Unger K (1947): Neurofibromatosis iridis (Recklinghausen’s disease). Arch Ophthalmol, 38: 654–659.Google Scholar
  108. 108.
    Van Der Hoeve J (1923): Eye diseases in tuberose sclerosis of the brain and in von Recklinghausen’s disease. Trans Ophthalmol Soc U.K., 43: 534–541.Google Scholar
  109. 109.
    Van Der Hoeve J (1932): Eye symptoms in phakomatoses. Trans Ophthalmol Soc U.K., 52: 380–401.Google Scholar
  110. 110.
    Von Papolczy F (1932): Ueber ein aus einem hinteren Ciliarnerven entspringendes intraretrobulbäres Neurinom. Von Graefe’s Arch Ophthalmol, 128: 325–335.Google Scholar
  111. 111.
    Von Recklinghausen F D (1882): Ueber die multiplen Fibrome der Haut und ihre Beziehung zu den multiplen Neuromen. Ed Hirschwald, Berlin.Google Scholar
  112. 112.
    Waardenburg P J (1963): Genetics and ophthalmology. Vol. 2, Neuro-ophthalmology, Ed. Van Gorcum, Assen, 1340–1356.Google Scholar
  113. 113.
    Weleber R G, and Zonana J (1983): Iris hamartoma (Lisch nodules) in a case of segmental neurofibromatosis. Am J Ophthalmol, 96: 740–743.PubMedGoogle Scholar
  114. 114.
    Wheeler J M (1937): Plexiform neurofibromatosis (von Recklinghausen’s disease) involving the choroid, ciliary body and other structures. Am J Ophthalmol, 20: 368–375.Google Scholar
  115. 115.
    White J P, and Loewenstein A (1946): Pigmented primary tumour of optic disc (contribution to knowledge of phakomata of eye). Br J Ophthalmol, 80: 253–260.Google Scholar
  116. 116.
    Wiener A (1925): A case of neurofibromatosis with buphthalmos. Arch Ophthalmol, 54: 481–488.Google Scholar
  117. 117.
    Wiznia R A, Freedman J K, Mancini A D, and Shields J A (1987): Malignant melanoma of the choroid in neurofibromatosis. Am J Ophthalmol, 86: 684–687.Google Scholar
  118. 118.
    Wolff P G (1947): Von Recklinghausen’s disease. Am J Ophthalmol, 30: 1028.PubMedGoogle Scholar
  119. 119.
    Wolter J R (1965): Nerve fibrils in ovoid bodies with neurofibromatosis of the choroid. Arch Ophthalmol, 73: 696–699.PubMedGoogle Scholar
  120. 120.
    Wolter J R, and Butler R G (1963): Pigment spots of the iris and ectropion uveae. With glaucoma in neurofibromatosis. Am J Ophthalmol, 56: 964–973.PubMedGoogle Scholar
  121. 121.
    Wolter J R, Gonzales-Sirit R, and Mankin W J (1962): Neurofibromatosis of the choroid. Am J Ophthalmol, 54: 217–225.PubMedGoogle Scholar
  122. 122.
    Zakka K A, Summerer R W, Yee R D, Foos R Y, and Kim J (1979): Optociliary veins in a primary optic nerve sheath meningioma. Am J Ophthalmol, 87: 91–95.PubMedGoogle Scholar
  123. 123.
    Zamella F E, and Kirchhof B (1986): Computertomografische Befunde bei Orbitaveränderungen ins Rahmes der kindlichen Neurofibromatosis. Klin Mbl Augenheilk, 188: 57–59.Google Scholar
  124. 124.
    Zaret C R, Choromokos E A, and Meisler D M (1980): Cilio-optic vein associated with phakomatosis. Ophthalmology, 87: 330–336.PubMedGoogle Scholar

Copyright information

© Belgian Society of Ophthalmology, Leuven, Belgium and Kluwer Academic Publishers 1990

Authors and Affiliations

  • J. J. De Laey
    • 1
  • M. Hanssens
    • 1
  1. 1.Department of OphthalmologyUniversity HospitalGhentBelgium

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