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Monitoring of Antithrombotic Therapy with Radiolabelled Platelets

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Clinical Application of Radiolabelled Platelets

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 17))

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Abstract

In the mid of the last century (1852) the head of the Department of Pathology at the Vienna University Medical School, Carl von Rokitansky (49) was the first to claim that material from the blood stream is incorporated (“incrustation theory”) into the arterial wall. Bizzozero quite soon thereafter stressed the important role of platelets (3) in atherogenesis. The importance of parietal thrombus formation has been underlined again by J.B.Duguid (11) and got even more importance after the discovery of prostacyclin (prostaglandin (PG) 12) by Sir John Vane, Moncada and other (36). They claimed an important role in hemostasis via an action of platelet-cAMP (4) and a decreased in-vitro PG12-formation by the arterial wall in atherosclerosis (50).

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Author information

Authors and Affiliations

  1. Atherosclerosis Research Group (ASF) Vienna, Atherosclerosis and Thrombosis Research Group (ATK) of the Austrian Academy of Sciences, Vienna, Austria

    H. Sinzinger

  2. Department of Internal Medicine, Policlinic Vienna, Austria

    P. Fitscha

Authors
  1. H. Sinzinger
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  2. P. Fitscha
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Editor information

Editors and Affiliations

  1. Department of Neurology, Medical University Lübeck, Lübeck, Germany

    Ch. Kessler

  2. Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    M. R. Hardeman

  3. Department of Neurology, University of Heidelberg, Heidelberg, Germany

    H. Henningsen

  4. Department of Neurology, Cologne-Merheim Hospital, Cologne, Germany

    J.-N. Petrovici

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Sinzinger, H., Fitscha, P. (1990). Monitoring of Antithrombotic Therapy with Radiolabelled Platelets. In: Kessler, C., Hardeman, M.R., Henningsen, H., Petrovici, JN. (eds) Clinical Application of Radiolabelled Platelets. Developments in Nuclear Medicine, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0581-8_11

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  • DOI: https://doi.org/10.1007/978-94-009-0581-8_11

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