The Coordination of Syntheses of Bacteriochlorophyll and Bacteriochlorophyll-Binding Proteins in Rhodobacter capsulatus

  • Debra A. Young
  • Barry L. Marrs

Abstract

Although bacteriochlorophyll (Bchl) synthesis has been studied for many years, very little is known about the mechanisms that coordinate the synthesis of Bchl with the availability of proteins to bind it. This is an important regulatory point, since Bchl is a potent sensitizer for photodynamic killing, but when Bchl is properly complexed with proteins and carotenoids that aid in the efficient conversion of excitation energy into electrochemical energy, Bchl can be safely accumulated to high levels. One obvious means of limiting the accumulation of free Bchl would be through feedback inhibition of Bchl synthesis, but Lascelles (1) was unable to find evidence for such a regulatory pathway. Lascelles eventually proposed that Bchl was synthesized as a Bchl-protein complex. We have recently revived that hypothesis as an explanation for the mode of regulation observed for a new Bchl-regulatory gene, pufQ (2).

Keywords

Carrier Protein Feedback Inhibition RHODOBACTER CAPSULATUS Reaction Center Protein Obvious Means 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lascelles, J. (1968) in Advances in Microbial Physiology (Rose, A. H., and Wilkinson, J. F., ed.), Vol. 2, pp. 1–42, Academic Press, Inc., New YorkGoogle Scholar
  2. 2.
    Bauer, C. E., and Marrs, B. L. (1988) Proc. Nat. Acad. Sci. USA. 85: 7074–7078PubMedCrossRefGoogle Scholar
  3. 3.
    Richards, W. R. & Lascelles, J. (1969) Biochemistry, 8: 3473–3482PubMedCrossRefGoogle Scholar
  4. 4.
    Richards, W. R., Wallace, R. B., Tsao, M. S. and Ho, E. (1975) Biochemistry, 14, 5554–5561PubMedCrossRefGoogle Scholar
  5. 5.
    Bauer, C. E., Young, D. A., and Marrs, B. L. (1988) J. Biol. Chem. 263,4820–4826PubMedGoogle Scholar
  6. 6.
    Youvan, D. C, Ismail, S. and Bylina, E. J. (1985) Gene 38,19–30PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Debra A. Young
    • 1
  • Barry L. Marrs
    • 1
  1. 1.CR&D DeptE. I. du Pont de Nemours & Co., Inc.WilmingtonUSA

Personalised recommendations