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Regional differences in the transduction mechanisms of 5-hydroxytryptamine receptors in the mammalian brain

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

During the last ten years, binding studies with selective radioligands have contributed to the present knowledge of central 5-hydroxytryptamine (5-HT) receptors, leading to the identification of membrane-bound specific sites with pharmacological properties expected for such receptors. Three main classes of 5-HT binding sites designated 5-HT1,5-HT2 and 5-HT3 have been identified so far [1], Apparently a single homogeneous population of sites corresponds to each of the two latter classes (at least in the CNS), but clearcut evidence of heterogeneity of 5-HT1 sites has been reported [2]. Thus it could be established that 5-HT1 sites are a mixture of 4 distinct classes of high affinity sites for [3H]5-HT called 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D, whose proportions are extremely variable from one brain area to another, and also from one species to another.

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Authors
  1. M. Hamon
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  2. M. B. Emerit
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  3. S. el Mestikawy
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  4. M. C. Gallissot
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  5. H. Gozlan
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Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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Hamon, M., Emerit, M.B., el Mestikawy, S., Gallissot, M.C., Gozlan, H. (1990). Regional differences in the transduction mechanisms of 5-hydroxytryptamine receptors in the mammalian brain. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_4

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