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5-Hydroxytryptamine and related drugs and transmitter release from autonomic nerves in the cardiovascular system

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Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

Under in vivo conditions, 5-hydroxytryptamine (5-HT) and related drugs influence transmitter release from autonomic nerves in the cardiovascular system not only by acting on the sympathetic and parasympathetic nerve endings, but also by modifying ganglionic transmission [1] as well as central regulation of circulatory function [2, 3]. Within this framework, the present report will focus on effects of relevant drugs on the peripheral autonomic nerve endings, particularly those innervating cardiovascular tissues.

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References

  1. Fozard JR (1984): Neuronal 5-HT receptors in the periphery. Neuropharmacology 23 : 1473 – 1486.

    Article  CAS  PubMed  Google Scholar 

  2. Kuhn DM, Wolf WA, Lovenberg W (1980): Review of the role of the central serotonergic neuronal system in blood pressure regulation. Hypertension 2: 243 – 255.

    Article  CAS  PubMed  Google Scholar 

  3. Wolf WA, Kuhn DM, Lovenberg W (1981): Pressor effects of dorsal raphe stimulation and intrahypothalamic application of serotonin in the spontaneously hypertensive rat. Brain Res 208: 192 – 197.

    Article  CAS  PubMed  Google Scholar 

  4. McGrath MA (1977): 5-Hydroxytryptamine and neurotransmitter release in canine blood vessels. Inhibition by low and augmentation by high concentrations. Circ Res 41: 428–435.

    Article  CAS  PubMed  Google Scholar 

  5. Humphrey PPA (1978). The effects of a-adrenoceptor antagonists on contractile responses to 5-hydroxytryptamine in dog saphenous vein. Br J Pharmacol 63: 671 – 675.

    Article  CAS  PubMed  Google Scholar 

  6. Marin J, Arias M, Salaices M. Sanchez CF, Recio LM (1981): Vasoconstrictor effects of serotonin in the isolated superior mesenteric artery of cat. Gen Pharmacol 12: 97–101.

    Article  CAS  PubMed  Google Scholar 

  7. Freeman WK, Rorie DK, Tyce GM (1981): Effects of 5-hydroxytryptamine on neuroef- fector junction in human pulmonary artery. J appl Physiol Respir Environ 51: 693 – 698.

    CAS  Google Scholar 

  8. Göthert M, Schlicker E, Kollecker P (1986): Receptor mediated effects of serotonin and 5-methoxytryptamine on noradrenaline release in the rat vena cava and in the heart of the pithed rat. Naunyn-Schmiedeberg’s Arch Pharmacol 332: 124 – 130.

    Article  Google Scholar 

  9. . Göthert M, Dührsen U (1979): Effects of 5-hydroxytryptamine and related compounds on the sympathetic nerves of the rabbit heart. Naunyn-Schmiedeberg’s Arch Pharmacol 308: 9 – 18.

    Article  Google Scholar 

  10. Trendelenburg U (1960): The action of histamine and 5-hydroxytryptamine on isolated mammalian atria. J Pharmacol exp Ther 130: 450 – 460.

    CAS  PubMed  Google Scholar 

  11. Jacob J, Poite-Bevierre M (1960): Actions de la serotonine et de la benzyl-l-demethyl- 2,5-serotonine sur le coeur isole de lapin. Arch int Pharmacodyn Ther 127: 11 – 26.

    CAS  PubMed  Google Scholar 

  12. Fozard JR, Mwaluko GMP (1976): Mechanism of the indirect sympathomimetic effect of 5-hydroxytryptamine on the isolated heart of the rabbit. Br J Pharmacol 57: 115 – 125.

    Article  CAS  PubMed  Google Scholar 

  13. Fozard JR, Mobarok Ali ATM (1978): Receptors for 5-hydroxytryptamine on the sympathetic nerves of the rabbit heart. Naunyn-Schmiedeberg’s Arch Pharmacol 301: 223 – 235.

    Article  CAS  Google Scholar 

  14. Göthert M, Klupp N (1978): Cardiovascular effects of neurotoxic indolethylamines. Ann N YAcadSci 305: 457 – 476.

    Article  Google Scholar 

  15. Engel G, Göthert M, Hoyer D, Schlicker E, Hillenbrand K (1986): Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn-Schmiedeberg’s Arch Pharmacol 332: 1 – 7.

    Article  CAS  Google Scholar 

  16. Kilpatrick GJ, Jones BJ, Tyers MB (1987): Identification and distribution of 5-HT3 receptors in brain using radioligand binding. Nature 330: 746 – 748.

    Article  CAS  PubMed  Google Scholar 

  17. Neijt HC, Karpf A, Schoeffter P, Engel G, Hoyer D (1988): Characterisation of 5-HT3 recognition sites in membranes of NG 108–15 neuroblastoma-glioma cells with [3H]ICS 205–930. Naunyn-Schmiedeberg’s Arch Pharmacol 337: 493 – 499.

    Article  CAS  Google Scholar 

  18. Richardson BP, Engel G, Donatsch P, Stadler PA (1985): Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs. Nature 316: 126 – 131.

    Article  CAS  PubMed  Google Scholar 

  19. Göthert M, Dührsen U, Rieckesmann J-M (1979): Ethanol, anaesthetics and other lipophilic drugs preferentially inhibit 5-hydroxytryptamine- and acetylcholine-induced noradrenaline release from sympathetic nerves. Arch int Pharmacodyn Ther 242: 196–209.

    PubMed  Google Scholar 

  20. Fozard JR, Mobarok Ali ATM (1978): Blockade of neuronal tryptamine receptors by metoclopramide. European J Pharmacol 49: 109 – 112.

    Article  CAS  Google Scholar 

  21. Fozard JR, Mobarok Ali ATM, Newgrosh G (1979): Blockade of serotonin receptors on autonomic neurones by (–)-cocaine and some related compounds. European J Pharmacol 59: 195 – 210.

    Article  CAS  Google Scholar 

  22. Fozard JR (1984): MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors. Naunyn-Schmiedeberg’s Arch Pharmacol 326: 36 – 44.

    Article  CAS  Google Scholar 

  23. Bradley PB, Engel G, Feniuk W, Fozard JR, Humphrey PPA, Middlemiss DN, Mylecharane EJ, Richardson BP, Saxena PR (1986): Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology 25: 563 – 576.

    Article  CAS  PubMed  Google Scholar 

  24. Leff P, Martin G (1988): The classification of 5-hydroxytryptamine receptors. Medicinal Research Reviews 8: 187–202.

    Article  CAS  PubMed  Google Scholar 

  25. Peroutka SJ (1988): 5-Hydroxytryptamine receptor subtypes. Ann Rev Neurosci 11: 45–60.

    Article  CAS  PubMed  Google Scholar 

  26. Feniuk W, Humphrey PPA, Watts AD (1979): Presynaptic inhibitory action of 5-hydroxytryptamine in dog isolated saphenous vein. Br J Pharmacol 67: 247 – 254.

    Article  CAS  PubMed  Google Scholar 

  27. Watts AD, Feniuk W, Humphrey PPA (1981): A prejunctional action of 5-hydroxytryptamine and methysergide on noradrenergic nerves in dog isolated saphenous vein. J Pharm Pharmacol 33: 515 – 520.

    Article  CAS  PubMed  Google Scholar 

  28. Engel G, Gothert M, Muller-Schweinitzer E, Schlicker E, Sistonen L, Stadler PA (1983): Evidence for common pharmacological properties of [3H]5-hydroxytryptamine binding sites, presynaptic 5-hydroxytryptamine autoreceptors in CNS and inhibitory presynaptic 5-hydroxytryptamine receptors on sympathetic nerves. Naunyn-Schmiedeberg’s Arch Pharmacol 324: 116 – 124.

    Article  CAS  Google Scholar 

  29. Lorenz RR, Vanhoutte PM (1985): Prejunctional adrenergic inhibition by aggregating platelets in canine blood vessels. Am J Physiol 249: H685 – H689.

    Google Scholar 

  30. Cohen RA (1985): Serotonergic prejunctional inhibition of canine coronary adrenergic nerves. J Pharmacol Exp Ther 235: 76 – 80.

    CAS  PubMed  Google Scholar 

  31. Cohen RA (1987): Inhibition of adrenergic neurotransmission in canine tibial artery after exposure to 5-hydroxytryptamine in vitro. J Pharmacol Exp Ther 242: 493 – 499.

    CAS  PubMed  Google Scholar 

  32. Charlton KG, Bond RA, Clarke DE (1986): An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidney. Apparent distinction from the 5-HT1A, 5-HT1B and 5-HT1c subtypes. Naunyn-Schmiedeberg’s Arch Pharmacol 332: 8 – 15.

    Article  CAS  Google Scholar 

  33. Göthert M, Kollecker P, Rohm N, Zerkowski HR (1986): Inhibitory presynaptic 5-hydroxytryptamine (5-HT) receptors on the sympathetic nerves of the human saphenous vein. Naunyn-Schmiedeberg’s Arch Pharmacol 332: 317 – 323.

    Article  Google Scholar 

  34. Schlicker E, Göthert M (1987): Noradrenaline release and its modulation via presynaptic serotonin receptors in blood vessels of spontaneously hypertensive rats. J Cardiovasc Pharmacol 10 (Suppl. 4): 141 – 143.

    Google Scholar 

  35. Molderings GJ, Fink K, Schlicker E, Göthert M (1987): Inhibition of noradrenaline release via presynaptic 5-HT1B receptors of the rat vena cava. Naunyn-Schmiedeberg’s Arch Pharmacol 336: 245 – 250.

    CAS  Google Scholar 

  36. Docherty JR (1988): Investigations of cardiovascular 5-hydroxytryptamine receptor subtypes in the rat. Naunyn-Schmiedeberg’s Arch Pharmacol 337: 1 – 8.

    Article  CAS  Google Scholar 

  37. Adler-Graschinsky E (1983): Dual presynaptic effects of 5-hydroxytryptamine on peripheral noradrenergic synapses. JAuton Pharmacol 3: 303 – 315.

    CAS  Google Scholar 

  38. Adler-Graschinsky E, Butta NV, Elgoyhen AB (1986): Serotonin uptake inhibitors and the prejunctional effects of serotonin on peripheral sympathetic nerves. Life Sciences 39: 61 - 68.

    Article  CAS  PubMed  Google Scholar 

  39. Phillips CA, Mylecharane EJ, Shaw J (1985): Mechanisms involved in the vasodilator action of 5-hydroxytryptamine in the dog femoral arterial circulation in vivo. European J Pharmacol 113: 325 – 334.

    Article  CAS  Google Scholar 

  40. Martinez AA, Lokhandwala MF (1980): Evidence for a presynaptic inhibitory action of 5-hydroxytryptamine on sympathetic neurotransmission to the myocardium. European J Pharmacol 63: 303 – 311.

    Article  CAS  Google Scholar 

  41. Kimura T, Satoh S (1983): Presynaptic inhibition by serotonin of cardiac sympathetic transmission in dogs. Clin Exp Pharmacol Physiol 10: 535 – 542.

    Article  CAS  PubMed  Google Scholar 

  42. Molderings GJ, Göthert M, Fink K, Roth E, Schlicker E (1989): Inhibition of noradrenaline release in the pig coronary artery via a novel serotonin receptor. Eur J Pharmacol 164: 213–222.

    Article  CAS  PubMed  Google Scholar 

  43. Bom AH, Duncker DJ, Saxena PR, Verdouw PD (1988): 5-Hydroxytryptamine-induced tachycardia in the pig: possible involvement of a new type of 5-HT receptor. Br J Pharmacol 93:663–671.

    Article  CAS  PubMed  Google Scholar 

  44. Verbeuren TJ, Jordaens FH, Herman AG (1983): Accumulation and release of [3H]-5- hydroxytryptamine in saphenous veins and cerebral arteries of the dog. J Pharmacol Exp Ther 226: 579–588.

    CAS  PubMed  Google Scholar 

  45. Saito A, Lee TJ-F (1987): Serotonin as an alternative transmitter in sympathetic nerves of large cerebral arteries of the rabbit. Circ Res 60: 220–228.

    Article  CAS  PubMed  Google Scholar 

  46. Kilbinger H, Pfeuffer-Friedrich I (1985): Two types of receptors for 5-hydroxytryptamine on the cholinergic nerves of the guinea-pig myenteric plexus. Br J Pharmacol 85: 529–539.

    Article  CAS  PubMed  Google Scholar 

  47. Fozard JR, Kilbinger H (1985): 8-OH-DPAT inhibits transmitter release from guinea-pig enteric cholinergic neurones by activating 5-HT1A receptors. Br J Pharmacol 86, 601 P.

    Article  Google Scholar 

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Authors
  1. M. Göthert
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  2. K. Fink
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  3. G. Molderings
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  4. E. Schlicker
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters  & P. Bevan  & 

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© 1990 Springer Science+Business Media Dordrecht

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Göthert, M., Fink, K., Molderings, G., Schlicker, E. (1990). 5-Hydroxytryptamine and related drugs and transmitter release from autonomic nerves in the cardiovascular system. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_21

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

  • Online ISBN: 978-94-009-0479-8

  • eBook Packages: Springer Book Archive

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