Effects of abrupt coronary occlusion on Doppler ejection dynamics in man

  • Fareed Khaja
  • Hani N. Sabbah
  • James F. Brymer
  • Paul D. Stein
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 105)


In experimental animals, brief periods of acute coronary artery occlusion can result in a marked impairment of regional left ventricular wall function [1–3]. The magnitude of global impairment of left ventricular function that accompanies regional wall motion abnormalities is dependent upon the extent of left ventricular ischemic mass [4]. Recently, with the advent of percutaneous transluminal coronary angioplasty (PTCA), transient occlusion of a coronary artery with the angioplasty balloon provided a model through which regional and global left ventricular function can be assessed in patients during brief periods of myocardial ischemia.


Coronary Occlusion Collateral Vessel Peak Acceleration Balloon Inflation Regional Wall Motion Abnormality 
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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Fareed Khaja
    • 1
  • Hani N. Sabbah
    • 1
  • James F. Brymer
    • 1
  • Paul D. Stein
    • 1
  1. 1.Henry Ford Heart and Vascular InstituteDetroitUSA

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