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Mitochondrial injury in the oxygen-depleted and reoxygenated myocardial cell

  • Chapter
Pathophysiology of Severe Ischemic Myocardial Injury

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 104))

Abstract

The myocardium cannot maintain its normal energetic state without oxidative energy production by the mitochondria. Therefore, during insufficient oxygen supply, the myocardial cell becomes progressively depleted of its energy reserves and ultimately deteriorates. Recovery of the myocardium from a period of oxygen depletion requires sufficient preservation of mitochondrial function. Apart from their central role in energy metabolism, mitochondria also perform a vital function in cellular Ca2+ homeostasis, since the mitochondria represent the largest intracellular compartment for the sequestration of excess Ca2+ from the cytosol. Control of cytosolic Ca2+ concentration becomes disturbed in energy deficiency and can be re-normalized when mitochondrial energy production is restored. For these reasons, damage of the mitochondria may be of crucial importance for recovery from states of cellular oxygen deprivation (anoxia, ischemia).

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  1. Physiologisches Institut I, Universität Düsseldorf, Moorenstr. 5, D-4000, Düsseldorf 1, Germany

    Hans Michael Piper

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  1. Institute of Physiology, University of Düsseldorf, Düsseldorf, Germany

    Hans Michael Piper

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Piper, H.M. (1990). Mitochondrial injury in the oxygen-depleted and reoxygenated myocardial cell. In: Piper, H.M. (eds) Pathophysiology of Severe Ischemic Myocardial Injury. Developments in Cardiovascular Medicine, vol 104. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0475-0_6

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  • DOI: https://doi.org/10.1007/978-94-009-0475-0_6

  • Publisher Name: Springer, Dordrecht

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