The critical ATP threshold hypothesis

  • P. G. Spieckermann
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 104)


Despite the discussions in other sections of this book on the final causes of cell death, this chapter will analyse whether any correlation exists during ischemia between the cellular energetic situation and disturbances of functions, metabolism and structure of myocardial cells. In this context, the question arises as to whether a critical cellular ATP level marks the transgression from a living to a dead cell, marking a ‘point of no return’.


Myocardial Oxygen Consumption Cardioplegic Solution High Energy Phosphate Disturbed Function Left Heart Bypass 
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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • P. G. Spieckermann
    • 1
  1. 1.Institute of Medical PhysiologyUniversity of ViennaAustria

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