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Myocardial release of hypoxanthine and lactate during coronary angioplasty

A quickly reversibe phenomenon, but for how long?
  • Patrick W. Serruys
  • Federico Piscione
  • William Wijns
  • Johan A. J. Hegge
  • Eef Harmsen
  • Marcel Van Den Brand
  • Pim De Feyter
  • Paul G. Hugenholtz
  • Jan W. De Jong
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 101)

Abstract

Until recently the assessment of alteration in myocardial metabolism in man early after an abrupt occlusion of a major coronary artery has not been feasible. Percutaneous transluminal coronary angioplasty (PTCA), however, now provides a unique opportunity to study the time course of these metabolic changes during the transient interruption of coronary flow by the balloon occlusion sequence in patients with single-vessel disease and without angiographically demonstrable collateral circulation [1, 2]. The need to detect any persisting metabolic or mechanical dysfunction becomes of even greater concern as the number of dilated vessels and the duration of balloon inflation tend to increase, thereby enhancing both the extent and the severity of ischemia. The risk exists that the damage induced by the intervention may exceed its benefit.

Keywords

Coronary Sinus Coronary Occlusion Reactive Hyperemia Occlusion Pressure Coronary Vascular Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers, Dordrecht 1990

Authors and Affiliations

  • Patrick W. Serruys
  • Federico Piscione
  • William Wijns
  • Johan A. J. Hegge
  • Eef Harmsen
  • Marcel Van Den Brand
  • Pim De Feyter
  • Paul G. Hugenholtz
  • Jan W. De Jong

There are no affiliations available

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