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The chemistry and structure-activity relationships of some new prodrugs of vinca alkaloids

  • K. S. P. Bhushana Rao
  • M.-P. Collard
  • J. P. Dejonghe
  • A. Trouet

Abstract

The alkaloids are natural products grouped together by their common possession of a basic nitrogen. The bisindole alkaloids comprise a large and complex group of naturally occurring organic compounds possessing the indole or dihydroindole nucleus. Among these we deal precisely with the subgroup from Aspidosperma-cleavamine. An illustration of the complexity of the structures encountered in this field are the antitumour alkaloids vinblastine (VLB) and vincristine (VCR). They are derived from the Madagascan periwinkle plant Catharanthus roseus G. Don. The biological, pharmacological, toxicological and clinical aspects of these alkaloids have been reviewed extensively1,2.

Keywords

P388 Cell Antitumour Activity Vinca Alkaloid DBA2 Mouse ANTITUMOUR Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Blackie & Son Ltd 1990

Authors and Affiliations

  • K. S. P. Bhushana Rao
  • M.-P. Collard
  • J. P. Dejonghe
  • A. Trouet

There are no affiliations available

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