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Hypoxia-selective agents: radiosensitisers and cytotoxins

  • Chapter
The Chemistry of Antitumour Agents

Abstract

There is now considerable evidence from radiobiological and clinical studies that the majority of solid human tumours contain a population of clonogenic cells which is poorly oxygenated as a result of inefficient blood supply1–3. The presence of such oxygen-deprived hypoxic (or anoxic) cells probably represents a limiting factor in the successful local control of these tumours by classical therapeutic treatment4,5. Although recent studies suggest that partial reoxygenation of such cells may occur between the radiation fractions used in current clinical radiotherapy, it is clear that hypoxia continues to pose a significant problem with certain tumours2–4.

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  1. T. C. Jenkins
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  1. Drug Development Section, Institute of Cancer Research, UK

    Derry E. V. Wilman

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© 1990 Blackie & Son Ltd

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Jenkins, T.C. (1990). Hypoxia-selective agents: radiosensitisers and cytotoxins. In: Wilman, D.E.V. (eds) The Chemistry of Antitumour Agents. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0397-5_13

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  • DOI: https://doi.org/10.1007/978-94-009-0397-5_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6665-5

  • Online ISBN: 978-94-009-0397-5

  • eBook Packages: Springer Book Archive

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