Evaluation: how should a new treatment be evaluated?

  • J. G. McVie
Part of the Cancer Biology and Medicine book series (CABM, volume 3)


The testing of new therapies in patients is a major challenge. The clinical trial has to be conducted to the highest ethical standards, yet it has to be designed to give the maximum chance of detecting a therapeutic effect whilst protecting patients from unnecessary exposure to an ineffective drug or unacceptable toxicity. This chapter will consider conventional cytotoxic drugs and some new molecules emerging from the laboratory which present new problems for clinical assessment.


Epidermal Growth Factor Receptor Soft Tissue Sarcoma Capillary Leak Syndrome Familial Polyposis Coli Intermediate Marker 
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© Kluwer Academic Publishers 1992

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  • J. G. McVie

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