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Etiology of organ-specific autoimmunity

  • G. S. Eisenbarth

Abstract

Fundamental questions concerning autoimmune disorders include:
  1. 1.

    What genetic elements determine disease susceptibility?

     
  2. 2.

    What activates/suppresses autoimmunity in genetically susceptible individuals?

     
  3. 3.

    What are the target autoantigens (initiating, perpetuating, secondary)?

     
  4. 4.

    What are the effector mechanisms?

     
  5. 5.

    What are the clinical sequelae of answers to the above questions in terms of disease prevention with, in particular, antigen-specific therapies?

     

Keywords

Major Histocompatibility Complex Celiac Disease Glutamic Acid Decarboxylase Insulin Autoantibody Rubella Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers and Axcan Pharma, Inc. 1994

Authors and Affiliations

  • G. S. Eisenbarth

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