Etiology of organ-specific autoimmunity

  • G. S. Eisenbarth


Fundamental questions concerning autoimmune disorders include:
  1. 1.

    What genetic elements determine disease susceptibility?

  2. 2.

    What activates/suppresses autoimmunity in genetically susceptible individuals?

  3. 3.

    What are the target autoantigens (initiating, perpetuating, secondary)?

  4. 4.

    What are the effector mechanisms?

  5. 5.

    What are the clinical sequelae of answers to the above questions in terms of disease prevention with, in particular, antigen-specific therapies?



Major Histocompatibility Complex Celiac Disease Glutamic Acid Decarboxylase Insulin Autoantibody Rubella Infection 
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© Kluwer Academic Publishers and Axcan Pharma, Inc. 1994

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  • G. S. Eisenbarth

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