Skip to main content

Therapy of IBD in 1994: a surgeon’s perspective

  • Chapter
Inflammatory Bowel Disease
  • 120 Accesses

Abstract

The options of surgical therapy for ulcerative colitis patients include total proctocolectomy and Brooke ileostomy, total proctocolectomy and the continent ileostomy, subtotal colectomy and ileorectal anastomosis, as well as the pelvic pouch procedure. A stoma is required for the first two mentioned procedures, and no stoma is required for subtotal colectomy and ileorectal anastomosis and the pelvic pouch procedure. In our experience, as well as others, there are very few candidates that are now acceptable for a colectomy and ileorectal anastomosis alone. All of the above procedures achieve continence except for the conventional ileostomy, but the reoperation rates for all of the procedures vary from 25–50% with the continent ileostomy to ~ 10–12% following the pelvic pouch procedure. With all types of surgeries there may be failures of therapy. As will be discussed below, the morbidity following a pelvic pouch procedure is considerable, and must be weighed against doing this procedure versus a total proctocolectomy and Brooke ileostomy. However, it must be stated that surgery is curative for ulcerative colitis, and ‘avoidance of colectomy’ should not be the major outcome measure when one is assessing a patient for either medical or surgery therapy. The disease is completely removed with any form of total proctocolectomy and in most cases with the pelvic pouch procedure, although recently the transitional zone as well as 1–2 cm of anal mucosa may be left behind using a stapled technique for the pelvic pouch procedure.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 16.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Stern H, Walfisch S, Mullen B, McLeod RS, Cohen Z. Cancer in an ileo-anal reservoir–a new late complication. Gut. 1990; 3: 473–5.

    Article  Google Scholar 

  2. Fleshman JW, Cohen Z, McLeod RS, Stern H, Blair J. The ileal reservoir and ileo-anal anastomosis procedure–factors affecting technical and functional outcome. Dis Colon Rectum. 1989; 31: 10–16.

    Article  Google Scholar 

  3. McIntyre TB, Pemberton J, Wolff B, Beart R, Dozois R. Comparing functional results one year and ten years after ileal pouch anal anastomosis for chronic ulcerative colitis. Dis Colon Rectum. 1994; 37: 303–7.

    Article  PubMed  CAS  Google Scholar 

  4. McLeod RS, Churchill N, Lock A, Vandenburg H, Cohen Z. Assessment of quality of life of patients with ulcerative colitis preoperatively and postoperatively. Gastroenterology. 1991; 101: 1307–13.

    PubMed  CAS  Google Scholar 

  5. Cohen Z. Ileo-anal pouches–is mucosectomy necessary? Can J Gastroenterol. 1993; 7: 1–3.

    Google Scholar 

  6. Lofberg R, Liljeqvust L, Lindquist K, Veress B, Reinholt GP, Tribukait B. Dysplasia and DNA aneuploidy in a pelvic pouch. Dis Colon Rectum. 1991; 34: 280–4.

    Article  PubMed  CAS  Google Scholar 

  7. Cohen Z, Steven W, O’Connor B, Stern H, McLeod RS. Continuing evolution of the pelvic pouch procedure. Surgery. 1992; 216: 506–12.

    CAS  Google Scholar 

  8. Archambault A, Feagan B, Fedorak R et al. The Canadian Crohn’s Disease Relapse Prevention Trial (CCRPT). Gastroenterology. 1992; 102: A591.

    Google Scholar 

  9. Lichtiger S. Cyclosporine therapy in inflammatory bowel disease–open-label experience. Mount Sinai J Med. 1990; 57: 315–19.

    CAS  Google Scholar 

  10. Lichtiger S, Present DH. Preliminary report: cyclosporine in treatment of severe active ulcerative colitis. Lancet. 1990; 336: 16–19.

    Article  PubMed  CAS  Google Scholar 

  11. Leddin DJ, Vanzanten V, Sidorov JJ, Stewart J, Tripathi D, Williams CD. Colectomy following treatment of Crohn’s colitis with cyclosporin. Post presentation. Trends in Inflammatory Bowel Disease Therapy. Victoria, British Columbia, April 1994.

    Google Scholar 

  12. Kozarek RA, Patterson DJ, Gelfand MD, Botoman VA, Ball TJ, Wilske KR. Methotrexate induces clinical and histologic remission in patients with refractory inflammatory bowel disease. Ann Intern Med. 1989; 110: 353–6.

    PubMed  CAS  Google Scholar 

  13. Kozarek RA, Patterson DJ, Gelfand MD, Ball TJ, Botomon VA. Long-term use of methotrexate in inflammatory bowel disease: severe disease 3, Drug Therapy 2. Seventh inning stretch. Gastroenterology. 1992; 102: A648 (abstr.).

    Google Scholar 

  14. Arora S, Katkov WN, Cooley J et al. A double blind, randomized, placebo-controlled trial of methotrexate in Crohn’s disease. Gastroenterology. 1993; 102: A647.

    Google Scholar 

  15. Lichtiger S, Present DH, Kornbluth A, Hanauer S. Cyclosporin A in the treatment of severe, refractory ulcerative colitis: a double blinded placebo controlled trial. Gastroenterology. 1993; 102 (4): A732.

    Google Scholar 

  16. Archambault A, Feagan B, Fedorak R et al. The Canadian Crohn’s Relapse Prevention Trial. Gastroenterology. 1992; 4: A591.

    Google Scholar 

  17. Corman E, Reinus JF. Cyclosporine use in steroid-resistant Crohn’s disease–grasping at new straws? Am J Gastroenterol. 1990; 85: 758–9.

    Google Scholar 

  18. Pemberton JH, Kelly KA, Beart RW, Dozois R, Wolff B, Ilstrup DM. Ileal pouch anal anastomosis for chronic ulcerative colitis–long term results. Ann Surg. 1987; 206: 504–13.

    Article  PubMed  CAS  Google Scholar 

  19. Salemans JM, Nagengast M, Lubbers EJ, Kuijpers JH. Postoperative and long-term results of ileal pouch anal anastomosis for ulcerative colitis in familial polyposis. Dig Dis Sci. 1992; 37: 1882–9.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Kluwer Academic Publishers and Axcan Pharma, Inc.

About this chapter

Cite this chapter

Cohen, Z. (1994). Therapy of IBD in 1994: a surgeon’s perspective. In: Sutherland, L.R., et al. Inflammatory Bowel Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0371-5_42

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0371-5_42

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6653-2

  • Online ISBN: 978-94-009-0371-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics