Genetic factors in animal models of intestinal inflammation

  • R. B. Sartor


Clinical investigators have compellingly documented a genetic component in ulcerative colitis and Crohn’s disease1. There is an increased incidence of inflammatory bowel disease (IBD) in family members, a predilection for these disorders in certain genetically defined ethnic groups, higher concordance of disease in monozygotic versus dizygotic twins, and familial patterns of clinical phenotypes. However, human genetic research has not yet provided clinically useful disease susceptibility markers, or an understanding of the immunopathogenesis of IBD.


Inflammatory Bowel Disease Ulcerative Colitis Inflammatory Bowel Disease Patient Intestinal Inflammation Human Inflammatory Bowel Disease 
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© Kluwer Academic Publishers and Axcan Pharma, Inc. 1994

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  • R. B. Sartor

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