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How to critically appraise a clinical trial

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Inflammatory Bowel Disease

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Abstract

The prescription of medications is a daily activity for most physicians. The act of prescribing incorporates a number of factors including issues related to effectiveness, appropriate use, comparability with other medications, adverse events and cost. The answers to most of these issues can be found within the body of the available medical literature. But therein lies a dilemma. Clinicians wish to base their therapeutic decisions on scientific data but are often overwhelmed by the number of case reports, open series and other therapeutic trials that are published each year.

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References

  1. Department of Clinical Epidemiology and Biostatistics, McMaster University Health Sciences Centre. How to read medical journals: V. To distinguish useful from useless or even harmful therapy. CMAJ. 1981; 124: 1156–62.

    Google Scholar 

  2. Meinert CL. Clinical trials design conduct, and analysis. Oxford: Oxford University Press; 1986.

    Google Scholar 

  3. Courtney MG, Nunes DP, Bergin CF et al. Randomised comparison of olsalazine and mesalazine in prevention of relapses in ulcerative colitis. Lancet. 1992; 339: 1279–81.

    Article  PubMed  CAS  Google Scholar 

  4. Caprilli R, Andreoli A, Capurso L et al. Oral mesalazine (5-aminosalicylic acid: Asacol) for the prevention of post-operative recurrence of Crohn’s disease. Aliment Pharmacol Ther. 1994; 8: 35–43.

    Article  PubMed  CAS  Google Scholar 

  5. Sutherland LR. Editorial: 5-aminosalicylates for prevention of recurrence in patients with Crohn’s disease: Time for a reappraisal? J Clin Gastroenterol. 1991; 13: 5–7.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. L. R. Sutherland
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Editors and Affiliations

  1. Division of Gastroenterology, The University of Calgary, Alberta, Canada

    L. R. Sutherland (Professor of Medicine, Head) (Professor of Medicine, Head)

  2. Division of Gastroenterology, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada

    S. M. Collins (Chief) (Chief)

  3. Division of Gastroenterology, St Luc Hospital, Montreal, Quebec, Canada

    F. Martin (Professor of Medicine, Chief) (Professor of Medicine, Chief)

  4. Department of Surgery, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada

    R. S. McLeod (Head of the Clinical Epidemiology Program, Associate Professor) (Head of the Clinical Epidemiology Program, Associate Professor)

  5. Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California, USA

    S. R. Targan (Director) (Director)

  6. Health Sciences Center, University of Calgary, Calgary, Alberta, Canada

    J. L. Wallace (Professor of Medical Physiology and Medicine) (Professor of Medical Physiology and Medicine)

  7. Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada

    C. N. Williams (Professor and Head) (Professor and Head)

  8. Faculty of Medicine, Clinical Research Center, Halifax, Nova Scotia, Canada

    C. N. Williams (Professor and Head) (Professor and Head)

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© 1994 Kluwer Academic Publishers and Axcan Pharma, Inc.

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Sutherland, L.R. (1994). How to critically appraise a clinical trial. In: Sutherland, L.R., et al. Inflammatory Bowel Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0371-5_18

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  • DOI: https://doi.org/10.1007/978-94-009-0371-5_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6653-2

  • Online ISBN: 978-94-009-0371-5

  • eBook Packages: Springer Book Archive

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