Immunomodulation of epithelium

  • M. H. Perdue


Over recent years many studies have provided evidence that the immune system is a key regulatory system of intestinal function. Immunophysiology has been coined as a term to describe the control of physiology by immune cells and their chemical mediators. The interaction of immune cells with the gut epithelium plays an important role in host defense, acting to eliminate pathogens, antigens and other noxious material from the lumen of the gastrointestinal tract.


Mast Cell Inflammatory Bowel Disease Celiac Disease Mast Cell Activation Peripheral Blood Mononuclear 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Perdue MH, Chung M, Gall DG. The effect of intestinal anaphylaxis on gut function in the rat. Gastroenterology. 1984; 86: 391–7.PubMedGoogle Scholar
  2. 2.
    Perdue MH, Gall DG. Transport abnormalities during intestinal anaphylaxis in the rat. Effect of anti-allergic agents. J Allergy Clin Immunol. 1985; 76: 498–503.PubMedCrossRefGoogle Scholar
  3. 3.
    Perdue MH, Gall DG. Intestinal anaphylaxis in the rat: jejunal response to in vitro antigen exposure. Am J Physiol. 1986; 250: G427–31.PubMedGoogle Scholar
  4. 4.
    Galli SJ, Kitamura Y. Genetically mast cell-deficient W/W Nand SI/SI dmice. Their value for the analysis of the roles of mast cells in biologic responses in vivo. Am J Pathol. 1987; 127: 191–8.PubMedGoogle Scholar
  5. 5.
    Wershil BK, Galli SJ. Gastrointestinal mast cells. New approaches for analyzing their function in vivo. Gastroenterol Clin N Am. 1991; 20: 613–27.Google Scholar
  6. 6.
    Perdue MH, Masson S, Wershil BK, Galli SJ. Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation. J Clin Invest. 1991; 87: 687–93.PubMedCrossRefGoogle Scholar
  7. 7.
    Stead RH, Perdue MH, Blennerhassett G, Kakuta Y, Sestini P, Bienenstock J. The innervation of mast cells. In: Freir S, editor. Neuroendocrine-immune network. Boca Raton: CRC Press; 1990: 19–37.Google Scholar
  8. 8.
    Perdue MH, Davison JS. Response of jejunal mucosa to electrical transmural stimulation and two neurotoxins. Am J Physiol. 1986; 251: G642–8.PubMedGoogle Scholar
  9. 9.
    Cooke HJ, Wang Y, Rogers R. Coordination of CL secretion and concentration by a histamine H2-receptor agonist in guinea pig distal colon. Am J Physiol. 1993; 265: G973–8.PubMedGoogle Scholar
  10. 10.
    Frieling T, Cooke HJ, Wood JD. Serotonin receptors on submucous neurons in guinea pig colon. Am J Physiol. 1991; 261: G1017–23.PubMedGoogle Scholar
  11. 11.
    Sjöqvist A, Cassuto J, Jodal M, Lundgren O. Actions of serotonin antagonists on choleratoxin-induced intestinal fluid secretion. Acta Physiol Scand. 1992; 145: 229–37.PubMedCrossRefGoogle Scholar
  12. 12.
    Wang L, Savedia S, Benjamin M, Perdue MH. The role of mast cells in intestinal immunophysiology. In: Mestecky J, editor. Advances in experimental medicine and biology. New York: Plenum Press, 1994 ( In press ).Google Scholar
  13. 13.
    Wang L, Stanis AM, Perdue MH. Activation of mast cells by substance P in the regulation of ion secretion in the mouse intestine. Gastroenterology. 1994 (In press) (Abstr.).Google Scholar
  14. 14.
    Pothoulakis C, Castagliuolo I, LaMont JT et al. CP 96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc Natl Acad Sci. 1994 (In press).Google Scholar
  15. 15.
    Crowe SE, Sestini P, Perdue MH. Allergic reactions of rat jejunal mucosa. Ion transport responses to luminal antigen and inflammatory mediators. Gastroenterology. 1990; 99: 7482.Google Scholar
  16. 16.
    Levine JD, Lam D, Taiwo YO, Donatoni P, Goetzl EJ. Hyperalgesic properties of 15lipoxygenase products of arachidonic acid. Proc Natl Acad Sci. 1986; 83: 5331–4.PubMedCrossRefGoogle Scholar
  17. 17.
    Diener M, Bridges RJ, Knoblock SF, Rummel W. Neuronally mediated and direct effects of prostaglandins on ion transport in rat colon descendens. Naunyn-Schmiedeberg’s Arch Pharmacol. 1989; 337: 74–8.Google Scholar
  18. 18.
    Hammerbeck DM, Brown DR. Neurally mediated actions of leukotrienes on ion transport in guinea pig distal colon. J Pharmacol Exp Ther. 1993; 264: 384–90.PubMedGoogle Scholar
  19. 19.
    Javed NH, Barrett KE, Wang YZ, Bidinger J, Cooke HJ. Enhanced tissue responsiveness in colonic ion transport of cow’s milk-sensitized guinea pigs. Agents Actions. 1994 (In press).Google Scholar
  20. 20.
    Crowe SE, Soda K, Stanisz AM, Perdue MH. Intestinal permeability in allergic rats: nerve involvement in antigen-induced changes. Am J Physiol. 1993; 264: G617–23.PubMedGoogle Scholar
  21. 21.
    Kimm MH, Curtis GH, Hardin JA, Gall DG. Transport of bovine serum albumin across rat jejunum: The role of the enteric nervous system. Am J Physiol. 1994; 266: G186–93.PubMedGoogle Scholar
  22. 22.
    Galli SJ, Gordon JR, Wershill BK. Cytokine production by mast cells and basophils. Curr Opin Immunol. 1991; 3: 865–73.PubMedCrossRefGoogle Scholar
  23. 23.
    Serafin WE, Austen KF. Mediators of immediate hypersensitivity reactions. N Engl J Med. 1987; 317: 30–4.PubMedCrossRefGoogle Scholar
  24. 24.
    Powell DW. Epithelial secretory responses to inflammation. Platelet activating factor and reactive oxygen metabolites. Ann NY Acad Sci. 1992; 664: 232–47.PubMedCrossRefGoogle Scholar
  25. 25.
    Payan DG. Neuropeptides and inflammation: the role of substance P. Annu Rev Med. 1989; 40: 341–52.PubMedCrossRefGoogle Scholar
  26. 26.
    Wershil BK, Wang Z-K, Gordon JR, Galli SJ. Recruitment of neutrophils during IgEdependent cutaneous late phase responses in the mouse is mast cell dependent: partial inhibition of the reaction with antiserum against tumor necrosis factor-a. J Clin Invest. 1991; 87: 446–53.PubMedCrossRefGoogle Scholar
  27. 27.
    McKay DM, Perdue H. Intestinal epithelial function: the case for immunophysiological regulation. Cells and mediators. (Part 1 of 2). Dig Dis Sci. 1993; 38: 1377–87.PubMedCrossRefGoogle Scholar
  28. 28.
    Ciacci C, Lind SE, Podolsky DK. Transforming growth factor-beta regulation of migration in wounded rat intestinal epithelial monolayers. Gastroenterology. 1993; 105: 93–101.PubMedGoogle Scholar
  29. 29.
    Crowe SE, Perdue MH. Gastrointestinal food hypersensitivity: basic mechanisms of pathophysiology. Gastroenterology. 1992; 103: 1075–95.PubMedGoogle Scholar
  30. 30.
    Baldassano RN, Schreiber S, Johnston RB, Fu RDJ, Muraki T, MacDermott RP. Crohn’s disease monocytes are primed for accentuated release of toxic oxygen metabolites. Gastroenterology. 1993; 105: 60–6.PubMedGoogle Scholar
  31. 31.
    Grisham MB, Yamada T. Neutrophils, nitrogen oxides, and inflammatory bowel disease. Ann NY Acad Sci. 1992; 664: 103–15.PubMedCrossRefGoogle Scholar
  32. 32.
    Nash S, Parkos C, Nusrat A, Delp C, Madara JL. In vitro model of intestinal crypt abscess. J Clin Invest. 1991; 87: 1474–7.PubMedCrossRefGoogle Scholar
  33. 33.
    Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration across a cultured intestinal epithelium. J Clin Invest. 1991; 88: 1605–12.PubMedCrossRefGoogle Scholar
  34. 34.
    Colgan SP, Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration cross cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion. J Cell Biol. 1993; 120: 785–98.PubMedCrossRefGoogle Scholar
  35. 35.
    Resnick MB, Colgan SP, Patapoff TW et al. Activated eosinophils evoke chloride secretion in model intestinal epithelia primarily via regulated release of 5’-AMP. J Immunol. 1993; 151: 5716–23.PubMedGoogle Scholar
  36. 36.
    Knutson TW, Bengtsson U, Dannaeus A et al. Intestinal reactivity in allergic and nonallergic patients: an approach to determine the complexity of the mucosal reaction. J Allergy Clin Immunol. 1993; 91: 553–9.PubMedCrossRefGoogle Scholar
  37. 37.
    Lavö B, Knutson L, Lööf L, Odlind B, Venge P, Hällgren R. Challenge with gliadin induces eosinophil and mast cell activation in the jejunum of patients with celiac disease. Am J Med. 1989; 87: 655–60.PubMedCrossRefGoogle Scholar
  38. 38.
    Denburg JA, Otsuka H, Ohnisi M, Ruhno J, Bienenstock J, Dolovich J. Contribution of basophil/mast cell and eosinophil growth and differentiation to the allergic tissue inflammatory response. Int Arch Allergy Appl Immunol. 1987; 82: 321–6.PubMedCrossRefGoogle Scholar
  39. 39.
    Dvorak AM, Monahan RA, Osage JE, Dickersin GR. Crohn’s disease: transmission electron microscopic studies. II. Immunologic inflammatory response. Alterations of mast cells, basophils, eosinophils, and the microvasculature. Hum Pathol. 1980; 11: 606–19.PubMedCrossRefGoogle Scholar
  40. 40.
    MacDonald TT, Spencer J. Cell-mediated immune injury in the intestine. Gastroenterol Clin N Am. 1992; 21: 367–86.Google Scholar
  41. 41.
    MacDonald TT, Spencer J. Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine. J Exp Med. 1988; 167: 1341–9.PubMedCrossRefGoogle Scholar
  42. 42.
    Perdue MH, Ramage JK, Burget D, Marshall JS, Masson S. Intestinal mucosal injury is associated with mast cell activation and leukotriene generation during Nippostrongylus induced inflammation in the rat. Dig Dis Sci. 1989; 34: 724–31.PubMedCrossRefGoogle Scholar
  43. 43.
    D’Inca R, Ernst P, Hunt RH, Perdue MH. Role of T lymphocytes in intestinal mucosal injury. Inflammatory changes in athymic nude rats. Dig Dis Sci. 1992; 37: 33–9.PubMedCrossRefGoogle Scholar
  44. 44.
    McKay DM, Croitoru K, Perdue MH. Activation of T lymphocytes causes increased permeability of T84 epithelial monolayers and reduces responses to secretagogues. Gastroenterology. 1993; 104: A741 (abstr.).Google Scholar
  45. 45.
    Roche JK, Planchon S, Lai J, Fiocchi C. Effect of ulcerative colitis immune mucosal cells upon epithelial barrier function. Gastroenterology. 1993; 104: A771 (abstr.).Google Scholar
  46. 46.
    Powell DW. Immunophysiology of intestinal electrolyte transport. In: Schultz SG, editor. Handbook of physiology: the gastrointestinal system. IV. Rockville, MD: American Physiologic Society; 1991: 591–641.Google Scholar
  47. 47.
    Berschneider HM, Powell DW. Fibroblasts modulate intestinal secretory response to inflammatory mediators. J Clin Invest. 1992; 89: 484–9.PubMedCrossRefGoogle Scholar
  48. 48.
    Bern MJ, Sturbaum CW, Karaylcin SS, Berschneider HM, Wachsman JT, Powell DW. Immune system control of rat and rabbit colonic electrolyte transport. Role of prostaglandins and enteric nervous system. J Clin Invest. 1989; 83: 1810–20.PubMedCrossRefGoogle Scholar

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© Kluwer Academic Publishers and Axcan Pharma, Inc. 1994

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  • M. H. Perdue

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