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Growth factors in IBD

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Inflammatory Bowel Disease

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Abstract

There are several morphological changes which can be discerned in the spectrum of inflammatory bowel disease (IBD), encompassed by the general processes of cell proliferation and differentiation. Examples which spring immediately to mind are the mucosal hyperplasia which accompanies ulcerative colitis, where colonic crypts lengthen and undergo increased crypt fission, the mucin cell depletion also found in ulcerative colitis, and the several metaplasias, such as pyloric metaplasia in Crohn’s disease, and Paneth cell metaplasia, commonest in ulcerative colitis. It is therefore relatively easy to manufacture a slot for the study of growth control in understanding the pathogenesis of IBD.

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Authors
  1. N. A. Wright
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, The University of Calgary, Alberta, Canada

    L. R. Sutherland (Professor of Medicine, Head) (Professor of Medicine, Head)

  2. Division of Gastroenterology, McMaster University, Faculty of Health Sciences, Hamilton, Ontario, Canada

    S. M. Collins (Chief) (Chief)

  3. Division of Gastroenterology, St Luc Hospital, Montreal, Quebec, Canada

    F. Martin (Professor of Medicine, Chief) (Professor of Medicine, Chief)

  4. Department of Surgery, University of Toronto, Mount Sinai Hospital, Toronto, Ontario, Canada

    R. S. McLeod (Head of the Clinical Epidemiology Program, Associate Professor) (Head of the Clinical Epidemiology Program, Associate Professor)

  5. Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California, USA

    S. R. Targan (Director) (Director)

  6. Health Sciences Center, University of Calgary, Calgary, Alberta, Canada

    J. L. Wallace (Professor of Medical Physiology and Medicine) (Professor of Medical Physiology and Medicine)

  7. Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada

    C. N. Williams (Professor and Head) (Professor and Head)

  8. Faculty of Medicine, Clinical Research Center, Halifax, Nova Scotia, Canada

    C. N. Williams (Professor and Head) (Professor and Head)

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© 1994 Kluwer Academic Publishers and Axcan Pharma, Inc.

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Wright, N.A. (1994). Growth factors in IBD. In: Sutherland, L.R., et al. Inflammatory Bowel Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0371-5_11

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  • DOI: https://doi.org/10.1007/978-94-009-0371-5_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6653-2

  • Online ISBN: 978-94-009-0371-5

  • eBook Packages: Springer Book Archive

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