Lung Metabolic Function as a Factor of Homeostasis Support After Thermal Injury
The lung is an organ whose importance has been little investigated. It has been established that apart from its well-studied respiratory function it possesses a complex and less well known metabolic function (Heinemann and Fishman, 1969; Syromiatnikova, 1974; Syromiatnikova et al 1987; Urazaeva and Dubilei, 1975; Said, 1977; Junod, 1982). The pulmonary blood circulation results in complex degradation, activation and inactivation of various endogenous agents influencing the blood circulation (vascular tension, their permeability, coagulation system, fibrinolysis). Arterial blood differs greatly from venous blood owing to the active metabolic processes. We showed (Vazina, 1988) that in the short period of pulmonary blood circulation changes appear in the coagulation system and the main bioenergetic substrate content (such as glucose and non-esterified fatty acids) increases significantly. The pulmonary metabolic function is also involved in increasing the bioenergetic potential of arterial blood. There has been discussion of the pulmonary detoxication function. All this testifies to the fact that the complex metabolic function of the lung plays an important role in homeostasis.
KeywordsFibrinolytic Activity Fibrinogen Concentration Total Body Surface Area Erythrocyte Deformability Fire Disaster
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