Possible Role of Ethanol-Derived Free Radicals in the Pathogenesis of Alcohol-Induced Liver Damage

  • E. Albano
  • P. Clot
  • M. Parola
  • M. U. Dianzani


In spite of decades of researches the biochemical mechanisms responsible for the hepatotoxic action consequent to alcohol abuse have not yet been completely elucidated [1]. Acetaldehyde, the main product of ethanol oxidation, is generally considered to be main responsible for the damaging effects associated to alcohol abuse [1]. In recent years, however, an increasing number of studies have suggested that, beside acetaldehyde, free radical intermediates might be involved in the pathogenesis of alcohol toxicity.


Alcoholic Liver Disease Alcoholic Patient Cytochrome P4502E Tienilic Acid Hydroxyethyl Radical 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • E. Albano
    • 1
  • P. Clot
    • 1
  • M. Parola
    • 2
  • M. U. Dianzani
    • 2
  1. 1.Department of Medical SciencesUniversity of TurinTurinItaly
  2. 2.Experimental Medicine and OncologyUniversity of TurinTurinItaly

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