Cell-mediated Immune Response in Hepatitis C Virus (HCV) Infection: Are Different Strategies Adopted by HCV and Hepatitis B Virus to Persist?

  • F. Fiaccadori
  • G. Missale
  • V. Lamonaca
  • R. Bertoni
  • A. Valli
  • A. Bertoletti
  • C. Boni
  • A. Cavalli
  • A. Penna
  • C. Ferrari


Immune-mediated mechanisms play an important role in the pathogenesis of liver cell injury and viral persistence in both HCV and hepatitis B virus (HBV) infections. However, the different vigor of HLA class I and class II restricted, anti-viral T cell responses in chronic hepatitis C and B and the different cytokine profiles within HCV and HBV infected livers suggest that these hepatotropic viruses have evolved different strategies to persist within their hosts and that different pathogenetic mechanisms are operative during HCV and HBV infections.


Chronic Hepatitis Liver Cell Injury Hepatotropic Virus Peripheral Blood Mononuclear Cell Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • F. Fiaccadori
    • 1
  • G. Missale
    • 1
  • V. Lamonaca
    • 1
  • R. Bertoni
    • 1
  • A. Valli
    • 1
  • A. Bertoletti
    • 1
  • C. Boni
    • 1
  • A. Cavalli
    • 1
  • A. Penna
    • 1
  • C. Ferrari
    • 1
  1. 1.Cattedra Malattie InfettiveUniversità di ParmaParmaItaly

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