Prevalence of Wild-Type and Variant Transcripts of Liver Estrogen Receptors in Chronic Liver Disease

  • E. Villa
  • A. Dugani
  • L. Cammellini
  • P. Buttafuoco
  • A. Grottola
  • I. Ferretti
  • A. Ferrari
  • F. Manenti

Summary

Variant estrogen receptor transcripts (lacking exon 5 of the hormone binding domain) investigated by Reverse transcription/Polymerase chain reaction in a series of patients with chronic active hepatitis, cirrhosis, cirrhosis with dysplasia and with hepatocellular carcinoma, increased progressively from CAH to HCC. Patients with liver cell dysplasia showed the same alterations as patients with HCC. As the variant ER transcripts when translated could give rise to truncated receptors still able to constitutively activate transcription, overexpression of these ER transcripts could be a key factor in liver carcinogenesis.

Keywords

Estrogen Receptor Chronic Active Hepatitis Variant Transcript Primary Hepatocellular Carcinoma Liver Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • E. Villa
    • 1
  • A. Dugani
    • 1
  • L. Cammellini
    • 1
  • P. Buttafuoco
    • 1
  • A. Grottola
    • 1
  • I. Ferretti
    • 1
  • A. Ferrari
    • 1
  • F. Manenti
    • 1
  1. 1.Department of Internal MedicineUniversity of ModenaItaly

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