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PET in Neurology — Clinical Problems

  • Cornelius Weiller
Part of the Developments in Nuclear Medicine book series (DNUM, volume 28)

Abstract

Positron emission tomography (PET) is continouing to have a major scientific impact on clinical neurology. Its role in routine clinical practice has been restricted by the lack of prospective studies on a large number of patients, mainly due to the restricted availability of PET centres at clinical institutions with access to appropriate patient data bases. However, recent progress has been made in several areas, which should stimulate the formulation of new questions, in which PET might be of major value.

Keywords

Positron Emission Tomography Clinical Positron Emission Tomography Positron Emission Tomography Centre Verb Generation Task Selective Neuronal Loss 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Powers WJ. Cerebral hemodynamics in ischemic cerebrovascular disease. Ann Neurol 1991; 29: 231–240.PubMedCrossRefGoogle Scholar
  2. 2.
    Heiss WD, Herholz K. Assessment of pathophysiology of stroke by positron emission tomography. European Journal of Nuclear Medicine 1994; 21: 455–465.PubMedCrossRefGoogle Scholar
  3. 3.
    Lassen NA, Olsen TS, Hqjgaard K, Skriver E. Incomplete infarction: A CT negative irreversible ischemic brain lesion. J Cereb Blood Flow Metab 1983; 3, suppl. 1: S602 - S603.Google Scholar
  4. 4.
    Weiller C, Willmes K, Reiche W, et al. The case of aphasia or neglect after striatocapsular infarction. Brain 1993; 116: 1509–1525.PubMedCrossRefGoogle Scholar
  5. 5.
    Garcia JH, Wagner S, Liu KF, Hu XJ. The neurologic deficit and the extent of neuronal necrosis attributable to middle cerebral artery occlusion. Stroke 1995; 26:(în press)Google Scholar
  6. 6.
    Weiller C, Ringelstein EB, Reiche W, Thron A, Buell U. The large striatocapsular infarct. A clinical and pathophysiological entity. Arch Neurol 1990; 47: 1085–1091.PubMedGoogle Scholar
  7. 7.
    Sette G, Baron JC, Young AR, et al. In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon. Stroke 1993; 24: 2046–2058.PubMedCrossRefGoogle Scholar
  8. 8.
    Lassen NA, Bartenstein PA, Lammertsma AA, et al. Benzodiazepine Receptor Quantification In Vivo in Humans Using [11C]Flumazenil and PET: Application of the Steady-State Principle. J Cereb Blood Flow Metab 1995; 15: 152–165.PubMedCrossRefGoogle Scholar
  9. 9.
    Weiller C, Chollet F, Friston KJ, Wise RJS, Frackowiak RSJ. Functional reorganization of the brain in recovery from striatocapsular infarction in man. Ann Neurol 1992; 31: 463–472.PubMedCrossRefGoogle Scholar
  10. 10.
    Weiller C, Ramsay SC, Wise RJS, Friston KJ, Frackowiak RSJ. Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction. Ann Neurol 1993; 33: 181–189.PubMedCrossRefGoogle Scholar
  11. 11.
    Rijntjes M, Weiller C, Krams M, Bauermann T, Diener HC, Faiss J. Functional Magnetic Resonance Imaging in Recovery from Motor Stroke. Stroke 1994; 25: 256. (abstract)Google Scholar
  12. 12.
    Weiller C, Isensee Ch, Rijntjes M, et al. Recovery from Wemiche’s aphasia - APET study. Ann Neurl 1995;(in press)Google Scholar
  13. 13.
    Eulitz C, Elbert T, Bartenstein PA, Weiller C, Müller SP, Pantev C. Comparison of magnetic and metabolic brain activity during a verb generation task. Neuro Report 1994; 6: 97–100.Google Scholar
  14. 14.
    Jørgensen HS, Nakayama H, Raaschou HO, Olsen TS. Effect of blood pressure and diabetes on stroke in progression. Lancet 1994; 344: 156–159.PubMedCrossRefGoogle Scholar
  15. 15.
    Powers WJ. Acute hypertension after stroke: The scientific basis for treatment decisions. Neurology 1993; 43: 461–467.PubMedGoogle Scholar
  16. 16.
    Powers WJ, Tempel LW, Grubb RL. Influence of cerebral hemodynamics on stroke risk: one year follow-up of 30 medically treated patients. Ann Neurol 1989; 25: 325–30.PubMedCrossRefGoogle Scholar
  17. 17.
    Weiller C, Ringelstein EB, Reiche W, Buell U. Clinical and hemodynamic aspects of low flow infarcts. Stroke 1991; 22: 1117–1123.PubMedCrossRefGoogle Scholar
  18. 18.
    Ad Hoc Committee American Heart Association. Guidelines for Carotid Endarterectomy. Stroke 1995; 26: 188–201.CrossRefGoogle Scholar
  19. 19.
    Vanninen R, Kolvisto K, Tulla H, Manninen J, Partanen K. Hemodynamic Effects of Carotid Endarterctomy by Magnetic Reson a nce Flow Quantification. Stroke 1995; 26: 84–89.PubMedCrossRefGoogle Scholar
  20. 20.
    Kleinschmidt A, Steinmetz H, Sitzer M, Merboldt K-D, Frahm J. Magnetic Resonance Imaging of Regional Cerebral Blood oxygenation changes under acetazolamine in carotid occlusive disease. Stroke 1995; 26: 106–110.PubMedCrossRefGoogle Scholar
  21. 21.
    Grady CL, Haxby JV, Horwitz B, et al. A longitudinal study of the early neuropsychological and cerebral metabolic changes in dementia of the Alzheimer type. J Clin Exp Neuropsychology 1987; 10: 579–596.Google Scholar
  22. 22.
    Sabri O, Hellwig D, Kaiser HJ, et al. Einfluss morphologischer Verhinderungen auf Durchblutung and Stoffwechsel bei zerebraler Mikroangiopathie. Nucl Med 1995;Google Scholar
  23. 23.
    McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS- ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 1984; 34: 939–944.PubMedGoogle Scholar
  24. 24.
    Spencer SS. The relative contributions of MRI, SPECT and PET Imaging in Epilepsy. Epilepsia 1994; 35 (suppl. 6): S72 - S89.PubMedCrossRefGoogle Scholar
  25. 25.
    Pawlik G, Fink GR, Kessler J, Heiss WD. PET and functional testing in temporal lobe epilepsy. Acta Neurol Scand 1994; Supplement 152: 150–156.CrossRefGoogle Scholar
  26. 26.
    Duncan JS. Discussion. Acta Neurol Scand 1994; Supplement 152: 135–136.CrossRefGoogle Scholar
  27. 27.
    Savic I, Persson A, Roland P, Pauli S, Sedvali G, Widen L. In vivo demonstration of reduced benzodiazepine receptor binding in human epileptic foci. Lancet 1988; 863.Google Scholar
  28. 28.
    Leblanc R, Meyer E, Bub D, Zatorre Ri, Evans AC. Language localization with activation positron emission tomography. Neurosurgery 1992; 31: 369–373.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Cornelius Weiller

There are no affiliations available

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