What is the current role of ultrafast CT in coronary imaging?

  • Bruce H. Brundage
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 186)


There is a great need for noninvasive imaging of the coronary arteries. The development of successful treatments for arresting or even reversing the atherosclerotic process makes it mandatory that we develop simple, safe and inexpensive ways to identify early coronary artery disease before acute myocardial infarction or sudden death occurs. Ultrafast computed tomography (UFCT) shows great promise as a method for imaging the coronary arteries with and without contrast medium enhancement. Numerous studies have now demonstrated that the identification and quantification of coronary artery calcium deposits by UFCT is simple to perform and accurate. The amount of coronary calcium present strongly correlates with the amount of plaque burden in the arteries and this correlates with the risk for the presence of obstructive disease and clinical events. Furthermore, early pilot studies indicate that coronary arterial lumens can be well visualized by the use of intravenous contrast enhancement and three-dimensional reconstruction. Clearly, UFCT will continue to play an important role in the imaging of coronary arteries.


Coronary Artery Coronary Artery Calcification Coronary Calcium Obstructive Coronary Artery Disease Current Role 
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  1. 1.
    McCullough CH, Robb RA. Ultrafast computed tomography: principles and instrumentation. In: Skorton DJ, Schelbert HR, Wolf GL, Brundage BH, editors. Marcus’ cardiac imaging. 2nd ed. Philadelphia: W. B. Saunders, 1996.Google Scholar
  2. 2.
    Blankenhorn DH. Coronary artery calcification, a review. Am J Med Sci 1961;242:1–10.CrossRefGoogle Scholar
  3. 3.
    Gianrossi R, Detrano R, Colombo A, Froelicher V. Cardiac fluoroscopy for the diagnosis of coronary artery disease: a meta analytic review. Am Heart J 1990;120:1179–88.PubMedCrossRefGoogle Scholar
  4. 4.
    Tanenbaum SR, Kondos GT, Veselik KE, Prendergast MR, Brundage BH, Chomka EV. Detection of calcific deposits in coronary arteries by ultrafast computed tomography and correlation with angiography. Am J Cardiol 1989;63:870–2.PubMedCrossRefGoogle Scholar
  5. 5.
    Breen JF, Sheedy PF 2nd, Schwartz RS et al. Coronary artery calcification detected with ultrafast CT as an indication of coronary artery disease. Radiology 1992;185:435–9.PubMedGoogle Scholar
  6. 6.
    Fallavollita JA, Brody AS, Bunnell IL, Kumar K, Canty JM Jr. Fast computed tomography detection of coronary calcification in the diagnosis of coronary artery disease. Comparison with angiography in patients < 50 years old. Circulation 1994;89:285–90.PubMedGoogle Scholar
  7. 7.
    Budoff MJ, Georgiou D, Brody A, et al. Ultrafast computed tomography as a diagnostic modality in detection of coronary artery disease: a multicenter study. Circulation 1996;93:898–904.PubMedGoogle Scholar
  8. 8.
    Kajinami K, Seki H, Takekoshi N, Mabuchi H. Noninvasive prediction of coronary atherosclerosis by quantification of coronary artery calcification using electron beam computed tomography: comparison with electrocardiographic and thallium exercise stress test results. J Am Coll Cardiol 1995;26:1209–21.PubMedCrossRefGoogle Scholar
  9. 9.
    Guerci AD, Spadaro LA, Popma J et al. Electron beam tomography of coronary arteries: Relationship of coronary calcium score to artériographie findings in asymptomatic and symptomatic adults [abstract]. Am J Card Imaging 1995;9(Suppl.1):5.Google Scholar
  10. 10.
    Detrano RC, Wong ND, Tang W, et al. Prognostic significance of cardiac cinefluoroscopy for coronary calcific deposits in asymptomatic high-risk subjects. J Am Coll Cardiol 1994;24:354–8.PubMedCrossRefGoogle Scholar
  11. 11.
    Detrano R, Tang W, Wong N et al. Coronary calcium predicts myocardial infarction in asymptomatic subjects after two years of follow-up [abstract]. J Am Coll Cardiol 1995;25(Special Issue): 13A.CrossRefGoogle Scholar
  12. 12.
    Margolis JR, Chen JT, Kong Y, Peter RH, Behar VS, Kisslo JA. The diagnostic and prognostic significance of coronary artery calcification. A report of 800 cases. Radiology 1980;137:609–16.PubMedGoogle Scholar
  13. 13.
    Detrano R, Hsiai T, Wang S et al. Prognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography. J Am Coll Cardiol 1996;27:285–90.PubMedCrossRefGoogle Scholar
  14. 14.
    Janowitz WR, Agatston AS, Viamonte M Jr. Comparison of serial quantitative evaluation of calcified coronary artery plaque by ultrafast computed tomography in persons with and without obstructive coronary artery disease. Am J Cardiol 1991;68:1–6.PubMedCrossRefGoogle Scholar
  15. 15.
    Kaufmann RB, Sheedy PF 2nd, Breen JF et al.: Detection of heart calcification with electron beam CT: interobserver and intraobserver reliability for scoring quantification. Radiology 1994;190:347–52.PubMedGoogle Scholar
  16. 16.
    Shah V, Claudio J, Wolfkiel CJ, Rich S, Devries SR. Reproducibility of coronary artery calcium scoring with ultrafast CT [abstract]. J Am Coll Cardiol 1992; 19(Suppl.A): 189 A.Google Scholar
  17. 17.
    Cutrone J, DeVito A, Lin S, Bakhsheshi H, Zalace C, Brundage B. Ultrafast CT 3-D coronary angiography: imagine the possibilities [abstract]. Am J Card Imaging 1994;9(Suppl.1):12.Google Scholar
  18. 18.
    Moshage WEL, Achenbach S, Seese B, Bachmann K, Kirchgeorg M. Coronary artery stenoses: three-dimensional imaging with electrocardiographically triggered, contrast agent-enhanced, electron beam CT. Radiology 1995; 196:707–14.PubMedGoogle Scholar
  19. 19.
    Brundage BH, Lipton MJ, Herfkens RJ et al.: Detection of patent coronary bypass grafts by computed tomography. A preliminary report. Circulation 1980;61:826–31PubMedGoogle Scholar

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© Kluwer Academic Publishers 1996

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  • Bruce H. Brundage

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