Oligonucleotide-Directed Recognition of Double-Helical DNA

  • Claude Hélène
  • Thérèse Garestier
Part of the NATO ASI Series book series (NSSE, volume 320)


The rational design of sequence-specific ligands of nucleic acids is an active field of research with several goals i) to provide molecular biologists with new tools to investigate the function of specific genes and the role of specific sequences in the control of gene expression, ii) to develop sequence-specific artificial nucleases that could cleave long DNA fragments at selected sites, e.g., for mapping genes on chromosomes, iii) to provide a rational basis for the development of new therapeutic agents based on selective modulation of gene expression.


Double Helix Triple Helix Major Groove Nucleic Acid Basis Intercalate Agent 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Claude Hélène
    • 1
  • Thérèse Garestier
    • 1
  1. 1.Laboratoire de Biophysique INSERM U.201 - CNRS URA 481Muséum National d’Histoire NaturelleParis Cedex 05France

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