Multivariable Control of a Continuous Culture

  • P. A. Gostomski
  • L. S. Clesceri
  • H. R. Bungay
Part of the NATO ASI Series book series (NSSE, volume 305)


Multivariable control of both pH and ammonium levels in an aerobic continuous yeast culture was demonstrated. A buffered glucose feed was used for pH control. This control loop was coupled with ammonium control using an on-line ammonia electrode suspended above a pH-adjusted sample stream from the fermentor. The dilution rate of the culture was the sum of the two individual feed rates. The advantages and implications of multivariable feedback control in continuous fermentation are discussed.


Feed Rate Dilution Rate Continuous Culture Caustic Solution Closed Loop Response 
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  1. Agrawal, Pramod, Lim, Henry C. (1984) ‘Analyses of Various Control Schemes for Continuous Bioreactors’ Advances In Biochemical Engineering/Biotechnology, 30, 61–90.CrossRefGoogle Scholar
  2. Bungay, H.R. (1972), ‘Continuous Culture With Proportional Control Of Substrate Concentration’, Proc. IV IFS Ferment. Technol. Today, 117-120.Google Scholar
  3. Fiechter, A. (1984), ‘Physical and Chemical Parameters of Microbial Growth’, Advances in Biochemical Engineering/Biotechnology, 30, 7–60.CrossRefGoogle Scholar
  4. Kleman, Gary L., Chalmers, Jeffrey J., Luli, Gregory W. and Strohl, William R. (1991), ‘Glucose-Stat, a Glucose-Controlled Continuous Culture’, Applied Environ. Micro., 57, 918–923Google Scholar
  5. Martin, G.A., and Hempfling, W.P. (1976), ‘Method for the regulation of microbial population density during continuous culture at high growth rates’, Arch. Microbiol., 107, 41–47.CrossRefGoogle Scholar
  6. Meschke, J., Bennemann, H., Herbst, H, Dormeier, S. and Hempel, D.C. (1988) ‘On-Line HPLC-Measurement and Control of Substrate in a Continuously Operated Biological Tank Reactor’, Bioprocess Engineering 3, 151–157.CrossRefGoogle Scholar
  7. Rutgers, Michiel, Balk, Peter A. and van Dam, Karel (1990) ‘Quantification of Multiple- Substrate Controlled Growth-Simultaneous Ammonium and Glucose Limitation in Chemo- stat Cultures of Klebsiella Pneumoniae’, Arch Microbiol 153, 478–484.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • P. A. Gostomski
    • 1
  • L. S. Clesceri
    • 2
  • H. R. Bungay
    • 1
  1. 1.Department of Chemical EngineeringRensselaer Polytechnic InstituteTroyUSA
  2. 2.Department of BiologyRensselaer Polytechnic InstituteTroyUSA

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