Skip to main content

Membrane Bioreactor with Immobilized Lipase: Modelling and Computational Considerations

  • Chapter
Computer and Information Science Applications in Bioprocess Engineering

Part of the book series: NATO ASI Series ((NSSE,volume 305))

  • 347 Accesses

Abstract

Several problems pertaining to the simulation of a three-phase hollow fiber bioreactor for the controlled accelerated hydrolysis of butterfat are addressed encompassing mathematical modelling, statistical fitting, and computational procedures. Common sense considerations and order of magnitude analyses are employed to simplify the general mass balances to substrate and enzyme forms whereas the rate expressions are derived on the basis of reasonable mechanisms postulated for the enzyme-catalyzed reaction and the enzyme deactivation/rearrangement.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Keniston, M., Novakovic, A., and Cosgrove, T. (1990). ‘A complex game of supply and demand’, Dairy Foods 91(11): 80–82.

    Google Scholar 

  2. Kilara, A. (1985) ‘Enzyme-modified lipid food ingredients’, Process Biochem 20: 33– 45.

    Google Scholar 

  3. Nelson, J. H. (1972) ‘Enzymatically produced flavors for fatty systems’, J. Am. Oil Chem. Soc. 49: 559–562.

    Article  CAS  Google Scholar 

  4. Lindsay, R. C. (1988) ‘Milkfat as a source of concentrated dairy flavors’, paper presented in the CDR Cheese Research Conference, Madison, Wisconsin, USA.

    Google Scholar 

  5. Godfrey, T. and Reichelt, J. R. (1983) ‘Introduction to industrial enzymology’ in T. Godfrey and J. Reichelt (eds.), Industrial Enzymology, Nature Press, New York, p. 1

    Google Scholar 

  6. Malcata, F. X., Reyes, H. R., Garcia, H. S., Hill, C. G., and Amundson, C. H. (1992) ‘The kinetics and mechanisms of reactions catalyzed by immobilized lipases’, Enz. Microb. Technol. 14: 426–446.

    Article  CAS  Google Scholar 

  7. Henley, J. P. and Sadana, A. (1986) ‘Deactivation theory’, Biotechnol. Bioeng. 28: 1277–1285.

    Article  CAS  Google Scholar 

  8. Malcata, F. X., Hill, C. G., and Amundson, C. H. (1992) ‘Hydrolysis of butteroil by immobilized lipase using a hollow fiber reactor: Part II: Uniresponse kinetic studies’, Biotechnol. Bioeng. 39: 984–1001.

    Article  CAS  Google Scholar 

  9. Segel, I. H. (1975) Enzyme Kinetics, Wiley, New York.

    Google Scholar 

  10. Caracotsios, M. and Stewart, W. E. (1985) ‘Sensitivity analysis of initial value problems with mixed ODE’s and algebraic equations’, Computers Chem. Eng. 9: 359–365.

    Article  CAS  Google Scholar 

  11. Jencks, W. P. (1969) Catalysis in Chemistry and Enzymology, Dover, New York.

    Google Scholar 

  12. Bard, Y. (1974) Nonlinear Parameter Estimation, Academic Press, New York.

    Google Scholar 

  13. Box, G. E. P. and Draper, N. R. (1965) ‘The Bayesian estimation of common parameters from several responses’, Biometrika 52: 355–365.

    Google Scholar 

  14. Stewart, W. E., Caracotsios, M., and Sørensen, J. P. (1992) GREG Software Package Documentation, Department of Chemical Engineering, University of Wisconsin, USA.

    Google Scholar 

  15. Box, G. E. P., Hunter, W. G., MacGregor, J. F., and Erjavec, J. (1973) ‘Some problems associated with the analysis of multiresponse models’, Technometrics 15: 33–51.

    Article  Google Scholar 

  16. Draper, N. R. and Smith, H. (1981) Applied Regression Analysis, Wiley, New York.

    Google Scholar 

  17. Bates, D. M. and Watts, D. G. (1988) Nonlinear Regression Analysis and its Applications, Wiley, New York.

    Book  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Malcata, F.X. (1996). Membrane Bioreactor with Immobilized Lipase: Modelling and Computational Considerations. In: Moreira, A.R., Wallace, K.K. (eds) Computer and Information Science Applications in Bioprocess Engineering. NATO ASI Series, vol 305. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0177-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0177-3_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6564-1

  • Online ISBN: 978-94-009-0177-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics