Skip to main content

Early detection of EBV infection and meaning in transplant patients

  • Chapter
Cancer in Transplantation: Prevention and Treatment

Part of the book series: Transplantation and Clinical Immunology ((TRAC,volume 27))

Abstract

Epstein–Barr virus (EBV) is a human B-lymphotropic herpes virus that causes infectious mononucleosis. It has also been associated with a number of primary and reactivated diseases, such as Burkitt lymphoma (BL), nasopharyngeal carcinoma (NPC), posttransplant lymphoproliferative disease and X-linked lymphoproliferative disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chevallier-Greco A, Manet E, Chavrier P, Mosnier C, Daillie J, Sergeant A. Both Epstein-Barr virus (EBV)-encoded transacting factors EB1 and EB2, are required to activate transcription from an EBV early promoter. EMBO J 1986; 5: 3243–3249.

    PubMed  CAS  Google Scholar 

  2. Countryman J, Jenson H, Seibl R, Wolf H, Miller G. Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J Virol 1987; 61: 3672–3679.

    PubMed  CAS  Google Scholar 

  3. Miller G. The switch between latency and replication of Epstein-Barr virus. J Infect Dis 1990; 161: 833–844.

    Article  PubMed  CAS  Google Scholar 

  4. Joab I, Triki H, De Saint-Martin J, Perricaudet M, Nicolas JC. Detection of anti Epstein-Barr virus trans-activator (ZEBRA) antibodies in sera from patients with human immunodeficiency virus. J Infect Dis 1991; 163: 53–56.

    Article  PubMed  CAS  Google Scholar 

  5. Savoie A, Perpête C, Carpentier L, Joncas J, Alfieri C. Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease. Blood 1994; 83: 2715–2722.

    PubMed  CAS  Google Scholar 

  6. Crompton, CH, Cheung RK, Donjon C, Miyazaki I, Feinmesser R, Hébert D, Dosch HM.: Epstein-Barr virus surveillance after renal transplantation. Transplantation 1994; 57: 1182–1189.

    Article  PubMed  CAS  Google Scholar 

  7. Laroche C, Drouet E, Brousset P, Pain C, Boibieux A, Biron F, Icart J, Denoyel G, Niveleau A. Measurement by polymerase chain reaction of the Epstein-Barr virus load in infectious mononucleosis and AIDS-related non Hodgkin’s lymphomas. J Med Virol 1995; 46: 66–74.

    Article  PubMed  CAS  Google Scholar 

  8. Cinque P, Brytting M, Vago L, Castagna A, Paravicini C, Zanchetta N, d’Arminio Monforte A, Wahren B, Lazzarin A, Linde A. Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system. Lancet 1993; 342: 398–401.

    Article  PubMed  CAS  Google Scholar 

  9. Shibata D, Weiss LM, Nathwani BN, Brynes RK, Levine AM Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin’s lymphoma. Blood 1991; 77: 1527–1533.

    PubMed  CAS  Google Scholar 

  10. Brousset P, Drouet E, Schlaifer D, Icart J, Payen C, Meggetto F, Marchou B, Massip B, Delsol G. Epstein-Barr virus (EBV) replicative gene expression in tumor cells of AIDS-related non Hodgkin’s lymphoma in relation to CD4 cell number and antibody titers to EBV. AIDS 1994; 8: 583–590

    Article  PubMed  CAS  Google Scholar 

  11. Peest D, Schaper B, Nashan B, Wonigeit K, Raude E, Pichlmayr R, Haverich A, Deicher H. High incidence of monoclonal immunoglobulins in patients after liver or heart transplantation. Transplantation 1988; 389–393

    Google Scholar 

  12. Gamier JL, Berger F, Betuel H, Vuillaume M, Chapuis-Cellier C, Blanc N, Faure JL, Dubernard JM, Lenoir G, Touraine JL. Epstein-Barr virus associated lymphoproliferative diseases (B cell lymphoma) after transplantation. Nephrol Dial Transplant 1989; 4: 818–823.

    Google Scholar 

  13. Niveleau A, Drouet E, Reynaud C, Fares F, Bruno C, Pain C. Polymerase Chain Reaction products containing 5-methyldeoxycytidine: A microplate immunoquantitation method. Nucleic Acids Res 1994; 22: 5508–5509.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Drouet, E.B., Chapuis-Cellier, C., Garnier, J.L., Touraine, J.L. (1996). Early detection of EBV infection and meaning in transplant patients. In: Touraine, J.L., Traeger, J., BĂ©tuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Cancer in Transplantation: Prevention and Treatment. Transplantation and Clinical Immunology, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0175-9_22

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0175-9_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6563-4

  • Online ISBN: 978-94-009-0175-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics