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Early detection of EBV infection and meaning in transplant patients

  • E. B. Drouet
  • C. Chapuis-Cellier
  • J. L. Garnier
  • J. L. Touraine
Part of the Transplantation and Clinical Immunology book series (TRAC, volume 27)

Abstract

Epstein–Barr virus (EBV) is a human B-lymphotropic herpes virus that causes infectious mononucleosis. It has also been associated with a number of primary and reactivated diseases, such as Burkitt lymphoma (BL), nasopharyngeal carcinoma (NPC), posttransplant lymphoproliferative disease and X-linked lymphoproliferative disease.

Keywords

Infectious Mononucleosis Polymerase Chain Reac Viral Capsid Antigen Monoclonal Gammapathy Zebra Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Chevallier-Greco A, Manet E, Chavrier P, Mosnier C, Daillie J, Sergeant A. Both Epstein-Barr virus (EBV)-encoded transacting factors EB1 and EB2, are required to activate transcription from an EBV early promoter. EMBO J 1986; 5: 3243–3249.PubMedGoogle Scholar
  2. 2.
    Countryman J, Jenson H, Seibl R, Wolf H, Miller G. Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J Virol 1987; 61: 3672–3679.PubMedGoogle Scholar
  3. 3.
    Miller G. The switch between latency and replication of Epstein-Barr virus. J Infect Dis 1990; 161: 833–844.PubMedCrossRefGoogle Scholar
  4. 4.
    Joab I, Triki H, De Saint-Martin J, Perricaudet M, Nicolas JC. Detection of anti Epstein-Barr virus trans-activator (ZEBRA) antibodies in sera from patients with human immunodeficiency virus. J Infect Dis 1991; 163: 53–56.PubMedCrossRefGoogle Scholar
  5. 5.
    Savoie A, Perpête C, Carpentier L, Joncas J, Alfieri C. Direct correlation between the load of Epstein-Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease. Blood 1994; 83: 2715–2722.PubMedGoogle Scholar
  6. 6.
    Crompton, CH, Cheung RK, Donjon C, Miyazaki I, Feinmesser R, Hébert D, Dosch HM.: Epstein-Barr virus surveillance after renal transplantation. Transplantation 1994; 57: 1182–1189.PubMedCrossRefGoogle Scholar
  7. 7.
    Laroche C, Drouet E, Brousset P, Pain C, Boibieux A, Biron F, Icart J, Denoyel G, Niveleau A. Measurement by polymerase chain reaction of the Epstein-Barr virus load in infectious mononucleosis and AIDS-related non Hodgkin’s lymphomas. J Med Virol 1995; 46: 66–74.PubMedCrossRefGoogle Scholar
  8. 8.
    Cinque P, Brytting M, Vago L, Castagna A, Paravicini C, Zanchetta N, d’Arminio Monforte A, Wahren B, Lazzarin A, Linde A. Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system. Lancet 1993; 342: 398–401.PubMedCrossRefGoogle Scholar
  9. 9.
    Shibata D, Weiss LM, Nathwani BN, Brynes RK, Levine AM Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin’s lymphoma. Blood 1991; 77: 1527–1533.PubMedGoogle Scholar
  10. 10.
    Brousset P, Drouet E, Schlaifer D, Icart J, Payen C, Meggetto F, Marchou B, Massip B, Delsol G. Epstein-Barr virus (EBV) replicative gene expression in tumor cells of AIDS-related non Hodgkin’s lymphoma in relation to CD4 cell number and antibody titers to EBV. AIDS 1994; 8: 583–590PubMedCrossRefGoogle Scholar
  11. 11.
    Peest D, Schaper B, Nashan B, Wonigeit K, Raude E, Pichlmayr R, Haverich A, Deicher H. High incidence of monoclonal immunoglobulins in patients after liver or heart transplantation. Transplantation 1988; 389–393Google Scholar
  12. 12.
    Gamier JL, Berger F, Betuel H, Vuillaume M, Chapuis-Cellier C, Blanc N, Faure JL, Dubernard JM, Lenoir G, Touraine JL. Epstein-Barr virus associated lymphoproliferative diseases (B cell lymphoma) after transplantation. Nephrol Dial Transplant 1989; 4: 818–823.Google Scholar
  13. 13.
    Niveleau A, Drouet E, Reynaud C, Fares F, Bruno C, Pain C. Polymerase Chain Reaction products containing 5-methyldeoxycytidine: A microplate immunoquantitation method. Nucleic Acids Res 1994; 22: 5508–5509.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • E. B. Drouet
  • C. Chapuis-Cellier
  • J. L. Garnier
  • J. L. Touraine

There are no affiliations available

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