Abstract

Skeletal muscle transplantation is practised in two quite different ways. Plastic surgeons commonly strive to transplant the mature differentiated tissue, attempting to minimize damage to the structure of the muscle fibres by restoring vascular and neural connections as quickly as possible [1]. The second method, and the one with which this article is concerned, involves the transplantation of precursors of skeletal muscle into sites in which they are able to follow their differentiative pathway to the formation of mature muscle tissue [2]. In this case, the need for re-establishment of vascularization and innervation is less urgent, for myogenic precursors are less sensitive to anoxia than mature muscle fibres. This was demonstrated by the observations of Studitsky [3] and Carlson [4] that when skeletal muscle is transplanted, intact or minced, without deliberate re-attachment of the vascular supply, then the mature muscle fibres undergo necrosis to be replaced, as the tissue eventually becomes spontaneously invaded by the vasculature, by new fibres formed from progeny of the surviving myogenic precursors resident in the muscle.

Keywords

Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Myogenic Cell Muscle Nerve Myogenic Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Frey M and Giovanoli P (eds) (1995) 4th International Muscle Symposium: Proceedings. Zurich: Klinik für Hand, Plastische und Wiederherstellungschirugie, Universitätsspital Zürich, 1995.Google Scholar
  2. 2.
    Partridge TA (1991) Invited review: myoblast transfer: a possible therapy for inherited myopathies? Muscle Nerve 14: 197–212.PubMedCrossRefGoogle Scholar
  3. 3.
    Studitsky AN (1964) Free auto-and homografts of muscle tissue in experimental animals. Ann N Y Acad Sci 120: 789–801.PubMedGoogle Scholar
  4. 4.
    Carlson BM (1973) The regeneration of skeletal muscle: a review. Am J Anat 137: 119–150.PubMedCrossRefGoogle Scholar
  5. 5.
    Bateson RG, Woodrow DF and Sloper JC (1967) Circulating cell as a source of myoblasts in regenerating injured mammalian skeletal muscle. Nature 213: 1035–1036.CrossRefGoogle Scholar
  6. 6.
    Law P (1982) Beneficial effects of transplanting normal limb-bud mesenchyme into dystrophic mouse muscles. Muscle Nerve 5: 619–627.PubMedCrossRefGoogle Scholar
  7. 7.
    Law PK and Yap JL (1979) New Muscle Transplant method produces normal twitch tension in dystrophic Muscle. Muscle Nerve 2: 356–363.PubMedCrossRefGoogle Scholar
  8. 8.
    Partridge TA, Grounds M and Sloper JC (1978) Evidence of fusion between host and donor myoblasts in skeletal muscle grafts. Nature 273: 306–308.PubMedCrossRefGoogle Scholar
  9. 9.
    Partridge TA (1982) Cellular interactions in the development and maintenance of skeletal muscle. In: Bellairs R, Curtis A and Dunn G (eds) The Social Abilities of Cells, pp 555–581. Cambridge: Cambridge University Press.Google Scholar
  10. 10.
    Lipton BH and Schultz E (1979) Developmental fate of skeletal muscle satellite cells. Science 205: 1292–1294.PubMedCrossRefGoogle Scholar
  11. 11.
    Jones PH (1979) Implantation of cultured regenerate muscle cells into adult rat muscle. Exp Neurol 66: 602–6610.PubMedCrossRefGoogle Scholar
  12. 12.
    Law PK, Goodwin TG and Wang MG (1988) Normal myoblast injections provide genetic treatment for murine dystrophy. Muscle Nerve 11: 525–533.PubMedCrossRefGoogle Scholar
  13. 13.
    Law PK, Goodwin TG and Li HJ (1988) Histoincompatible myoblast injection improves muscle structure and function of dystrophic mice. Transplant Proc 20: 1114–1119.PubMedGoogle Scholar
  14. 14.
    Arahata K, Hayashi YK, Koga R et al. (1993) Laminin in animal models for muscular dystrophy: defect of Laminin M in skeletal and cardiac muscles and peripheral nerve of the homozygous dystrophic dy/dy mouse. Proc Japan Acad 69: 259–264.CrossRefGoogle Scholar
  15. 15.
    Sunada Y, Bernier SM and Kozak CA, et al. (1994) Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus. J Biol Chem 269: 13729–13732.PubMedGoogle Scholar
  16. 16.
    Xu H, Christmas P and Wu XR et al. (1994) Defective basement membrane and lack of M-laminin in the dystrophic dy/dy mouse. Proc Nat Acad Sci USA 91: 5572–5576.PubMedCrossRefGoogle Scholar
  17. 17.
    Watt DJ, Lambert K, Morgan JE, et al. (1982) Incorporation of donor muscle precursor cells into an area of muscle regeneration in the host mouse. J Neurol Sci 57: 319–331.PubMedCrossRefGoogle Scholar
  18. 18.
    Watt DJ, Morgan JE and Partridge TA (1984) Use of mononuclear precursor cells to insert allogeneic genes into growing mouse muscles. Muscle Nerve 7: 741–750.PubMedCrossRefGoogle Scholar
  19. 19.
    Morgan JE, Watt DJ, Sloper JC et al. (1988) Partial correction of an inherited biochemical defect of skeletal muscle by grafts of normal muscle precursor cells. J Neurol Sci 86: 137–147.PubMedCrossRefGoogle Scholar
  20. 20.
    Partridge TA, Morgan JE, Coulton GR et al. (1989) Conversion of mdx myofibres from dystrophin-negative to -positive by injection of normal myoblasts. Nature 337: 176–9.PubMedCrossRefGoogle Scholar
  21. 21.
    Karpati G, Pouliot Y, Zubrzycka GE et al. (1989) Dystrophin is expressed in mdx skeletal muscle fibers after normal myoblast implantation. Am J Pathol 135: 27–32.PubMedGoogle Scholar
  22. 22.
    Morgan JE, Pagel CN, Sherratt T et al. (1993) Long-term persistence and migration of myogenic cells injected into pre-irradiated muscles of mdx mice. J Neurol Sci 115: 191–200.PubMedCrossRefGoogle Scholar
  23. 23.
    Morgan JE, Hoffman EP and Partridge TA (1990) Normal myogenic cells from newborn mice restore normal histology to degenerating muscles of the mdx mouse. J Cell Biol 111: 2437–2449.PubMedCrossRefGoogle Scholar
  24. 24.
    Morgan JE, Beauchamp JR, Pagel CN et al. (1994) Myogenic Cell Lines Derived from Transgenic Mice Carrying a Thermolabile T Antigen: A Model System for the Derivation of Tissue-Specific and Mutation-specific Cell Lines. Dev Biol 162: 1–13.CrossRefGoogle Scholar
  25. 25.
    Griggs RC and Karpati G (eds) (1990) Myoblast Transfer Therapy. New York: Plenum Press.Google Scholar
  26. 26.
    Hoffman EP, Morgan JE, Watkins SC, et al. (1990) Somatic reversion/suppression of the mouse mdx phenotype in vivo. J Neurol Sci 99: 9–25.PubMedCrossRefGoogle Scholar
  27. 27.
    Shimizu T, Matsumura K, Hashimoto K et al. (1988) A monoclonal antibody against a synthetic polypeptide fragment of dystrophin (amino acid sequence from position 215–264). Proc Japan Acad 64: 205–208.CrossRefGoogle Scholar
  28. 28.
    Nicholson LVB, Davison K, Johnson MA et al. (1989) Dystrophin in skeletal muscle: II. Immunoreactivity in patients with Xp21 muscular dystrophy. J Neurol Sci 94: 137–146.PubMedCrossRefGoogle Scholar
  29. 29.
    Huard J, Bouchard JP, Roy R et al. (1992) Human myoblast transplantation: preliminary results of 4 cases. Muscle Nerve 15: 550–60.PubMedCrossRefGoogle Scholar
  30. 30.
    Law PK, Bertorini TE, Goodwin TG et al. (1990) Dystrophin production induced by myoblast transfer therapy in Duchenne muscular dystrophy. Lancet 336: 114–5.PubMedCrossRefGoogle Scholar
  31. 31.
    Karpati G, Ajdukovic D, Arnold D et al. (1993) Myoblast transfer in Duchenne muscular dystrophy. Ann Neurol 34: 817.CrossRefGoogle Scholar
  32. 32.
    Gussoni E, Pavlath GK, Lanctot AM et al. (1992) Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation. Nature 356: 435–8.PubMedCrossRefGoogle Scholar
  33. 33.
    Watt DJ (1982) Factors which affect the fusion of allogeneic muscle precursors in vivo. Neuropath Appl Neurobiol 8: 137–147.CrossRefGoogle Scholar
  34. 34.
    Grounds MD, Partridge TA and Sloper JC (1980) The contribution of exogenous cells to regenerating skeletal muscle: an isoenzyme study of muscle allografts in mice. J Pathol 132: 325–341.PubMedCrossRefGoogle Scholar
  35. 35.
    Watt DJ, Morgan JE and Partridge TA (1992) Allografts of muscle precursor cells persist in the non-tolerized host. Neuromusc Disord 1: 345–355.CrossRefGoogle Scholar
  36. 36.
    Morgan JE, Coulton GR and Partridge TA (1987) Muscle precursor cells invade and repopulate freeze-killed skeletal muscles. Journal of Muscle Research and Cell Motility 8: 386–396.PubMedCrossRefGoogle Scholar
  37. 37.
    Labrecque C, Roy R and Tremblay JP (1992) Immune reactions after myoblast transplantation in mouse muscles. Transplant Proc 24: 2889–92.PubMedGoogle Scholar
  38. 38.
    Guérette B, Asselin I and Vilquin J-T et al. (1995) Lymphocyte infiltration following allo-and xenomyoblast transplantation in mdx mice. Muscle Nerve 18: 39–51.PubMedCrossRefGoogle Scholar
  39. 39.
    Irintchev A, Zweyer M and Wernig A (1995) Cellular and molecular reactions in mouse muscles after myoblast implantation. J Neurocytol 24: 319–331.PubMedCrossRefGoogle Scholar
  40. 40.
    Wernig A, Irintchev A and Lange G (1995) Functional effects of myoblast implantation into histoincompatible mice with or without immunosuppression. J Physiol 484: 493–504.PubMedGoogle Scholar
  41. 41.
    Vilquin J-T, Asselin I, Guérette B et al. (1995) Successful myoblast transplantation in mdx mice using Rapamycin. Transplantation 59: 422–449.PubMedGoogle Scholar
  42. 42.
    Kinoshita I, Vilquin J-T, Guerette B et al. (1994) Very efficient myoblast allotransplantation in mice under FK506 immunosuppression. Muscle Nerve 17: 1407–1415.PubMedCrossRefGoogle Scholar
  43. 43.
    Appleyard ST, Dunn MJ, Dubowitz V et al. (1985) Increased expression of HLA ABC class I antigens by muscle fibres in Duchenne muscular dystrophy, inflammatory myopathy, and other neuromuscular disorders. Lancet is 361–363.Google Scholar
  44. 44.
    Karpati G, Pouilot Y and Carpenter S (1988) Expression of immunoreactive major histocompatibility complex products in human skeletal muscles. Ann Neurol 23: 64–72.PubMedCrossRefGoogle Scholar
  45. 45.
    Emslie-Smith AM, Arahata K and Engel AG (1989) Major histocompatibility complex class 1 antigen expression, immunolocalization of interferon subtypes and T cell-mediated cytotoxicity in myopathies. Hum Pathol 20: 224–231.PubMedCrossRefGoogle Scholar
  46. 46.
    Ervasti JM, Ohlendieck K, Kahl SD et al. (1990) Deficiency of a glycoprotein component of the dystrophin complex in dystrophic muscle. Nature 345: 315–9.PubMedCrossRefGoogle Scholar
  47. 47.
    Matsumura K, Lee CC, Caskey CT et al. (1993) Restoration of dystrophin-associated proteins in skeletal muscle of mdx mice transgenic for dystrophin gene. Febs Lett 320: 276–80.PubMedCrossRefGoogle Scholar
  48. 48.
    Matsumura K and Campbell KP (1993) Deficiency of dystrophin-associated proteins: a common mechanism leading to muscle cell necrosis in severe childhood muscular dystrophies. Neuromusc Disord 3: 109–18.PubMedCrossRefGoogle Scholar
  49. 49.
    Huard J, Roy R, Bouchard JP et al. (1992) Human myoblast transplantation between immunohistocompatible donors and recipients produces immune reactions. Transplant Proc 24: 3049–51.PubMedGoogle Scholar
  50. 50.
    Law PK, Goodwin TG, Fang Q et al. (1991) Long-term improvement in muscle function, structure and biochemistry following myoblast transfer in DMD. Acta Cardiomiol 3: 281–301.Google Scholar
  51. 51.
    Sharma KR, Mynhier MA and Miller RG (1993) Cyclosporine increases muscular force generation in Duchenne muscular dystrophy. Neurobiology 43: 527–532.Google Scholar
  52. 52.
    Law PK, Goodwin TG, Fang QW et al. (1991) Myoblast transfer therapy for Duchenne muscular dystrophy. Acta Paediatr Jpn 33: 206–15.PubMedGoogle Scholar
  53. 53.
    Law PK (1992) Myoblast transplantation [letter]. Science 257: 1329–30.PubMedCrossRefGoogle Scholar
  54. 54.
    Law PK, Goodwin TG, Fang Q et al. (1993) Cell Transplantation as an experimental treatment for Duchenne muscular dystrophy. Cell Transplant 2: 485–505.PubMedGoogle Scholar
  55. 55.
    Beauchamp JR, Morgan JE, Pagel CN et al. (1994) Quantitative studies of the efficacy of myoblast transplantation. Muscle Nerve Suppl. 1: S261.Google Scholar
  56. 56.
    Young HE, Mancini ML, Wright RP et al. (1995) Mesenchymal stem cells reside withi the connective tissues of many organs. Dev Dynam 202: 137–144.CrossRefGoogle Scholar
  57. 57.
    Gibson AJ, Karasinski J, Relvas J et al. (1995) Dermal fibroblasts convert to a myogenic lineage in mdx mouse muscle. J Cell Sci 108: 207–214.PubMedGoogle Scholar
  58. 58.
    Acsadi G, Dickson G, Love DR et al. (1991) Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs. Nature 352: 815–8.PubMedCrossRefGoogle Scholar
  59. 59.
    Dunckley MG, Love DR, Davies KE et al. (1992) Retroviralmediated transfer of a dystrophin minigene into mdx mouse myoblasts in vitro. Febs Lett 296: 128–34.PubMedCrossRefGoogle Scholar
  60. 60.
    Dunkley MG, Wells DJ, Walsh FS et al. (1993) Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo. Hum Mol Genet 2: 717–723.CrossRefGoogle Scholar
  61. 61.
    Ragot T, Vincent N, Chafey P et al. (1993) Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of mdx mice. Nature 361: 647–50.PubMedCrossRefGoogle Scholar
  62. 62.
    Barr E and Leiden JM (1991) Systemic delivery of recombinant proteins by genetically modified myoblasts. Science 254: 1507–9.PubMedCrossRefGoogle Scholar
  63. 63.
    Dhawan J, Pan LC, Pavlath GK et al. (1991) Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science 254: 1509–12.PubMedCrossRefGoogle Scholar
  64. 64.
    Jiao S, Gurevich V and Wolff JA (1993) Long term correction of rat model of Parkinson<prime>s disease by gene therapy. Nature 362: 450–455.PubMedCrossRefGoogle Scholar
  65. 65.
    Yao SN, Wilson JM, Nabel EG et al. (1991) Expression of human factor IX in rat capillary endothelial cells: toward somatic gene therapy for hemophilia B. Proc Natl Acad Sci U S A 88: 8101–5.PubMedCrossRefGoogle Scholar
  66. 66.
    Yao S-N, Smith KJ and Kurachi K (1994) Primary myoblastmediated gene transfer: persistent expression of human factor IX in mice. Gene Therapy 2: 99–107.Google Scholar
  67. 67.
    Zhu N, Liggit D, Liu Y et al. (1993) Systemic gene expression after intravenous DNA delivery into adult mice. Science 261: 209–211.PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Terence Partridge
    • 1
  1. 1.Muscle Cell Biology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK

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