Skeletal muscle transplantation is practised in two quite different ways. Plastic surgeons commonly strive to transplant the mature differentiated tissue, attempting to minimize damage to the structure of the muscle fibres by restoring vascular and neural connections as quickly as possible [1]. The second method, and the one with which this article is concerned, involves the transplantation of precursors of skeletal muscle into sites in which they are able to follow their differentiative pathway to the formation of mature muscle tissue [2]. In this case, the need for re-establishment of vascularization and innervation is less urgent, for myogenic precursors are less sensitive to anoxia than mature muscle fibres. This was demonstrated by the observations of Studitsky [3] and Carlson [4] that when skeletal muscle is transplanted, intact or minced, without deliberate re-attachment of the vascular supply, then the mature muscle fibres undergo necrosis to be replaced, as the tissue eventually becomes spontaneously invaded by the vasculature, by new fibres formed from progeny of the surviving myogenic precursors resident in the muscle.


Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Myogenic Cell Muscle Nerve Myogenic Precursor 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Terence Partridge
    • 1
  1. 1.Muscle Cell Biology Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical SchoolHammersmith HospitalLondonUK

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