Hematopoietic cell transplantation for tolerance induction
A major focus of the entire transplant community has been to delineate anti-rejection strategies which, alone or via multifaceted approaches, result in the development of donor specific tolerance, thus obviating the need for chronic, generalized immunosuppression of the recipient. Many approaches which have proven successful in rodent models of solid organ or cellular transplantation have not translated well to large animals or humans. This may be due, in part, to a need for multifaceted immunointerventions when transplanting cells or organs between members of outbred, large animal populations.
KeywordsGraft Versus Host Disease Hematopoietic Cell Transplantation Allograft Survival Donor Bone Marrow Renal Allograft Survival
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