Experimental islet transplantation

  • Gordon C. Weir
  • Susan Bonner-Weir


Transplantation of the islets of Langerhans offers the possibility of curing diabetes, but the problem has turned out to be more complex than was envisioned in the early 1970s when the first successful experimental transplants were performed in rodents [1, 2]. Much energy has been devoted to transplantation of human islets obtained from cadaver donors into the liver, via the portal vein of immunosuppressed type I diabetics [3, 4]. These efforts have been disappointing because most have failed within a short period of time. The failures are interesting contrasts to the far more impressive results obtained with whole pancreas transplants and islet autotransplants [5, 6].


Beta Cell Pancreatic Duct Human Islet Islet Transplantation Beta Cell Mass 
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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Gordon C. Weir
    • 1
  • Susan Bonner-Weir
    • 1
  1. 1.Joslin Diabetes CenterBrigham and Women’s Hospital, Deaconess Hospital, Harvard Medical SchoolBostonUSA

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