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Experimental islet transplantation

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Yearbook of Cell and Tissue Transplantation 1996–1997

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Abstract

Transplantation of the islets of Langerhans offers the possibility of curing diabetes, but the problem has turned out to be more complex than was envisioned in the early 1970s when the first successful experimental transplants were performed in rodents [1, 2]. Much energy has been devoted to transplantation of human islets obtained from cadaver donors into the liver, via the portal vein of immunosuppressed type I diabetics [3, 4]. These efforts have been disappointing because most have failed within a short period of time. The failures are interesting contrasts to the far more impressive results obtained with whole pancreas transplants and islet autotransplants [5, 6].

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Author information

Authors and Affiliations

  1. Joslin Diabetes Center, Brigham and Women’s Hospital, Deaconess Hospital, Harvard Medical School, Boston, MA, 02215, USA

    Gordon C. Weir & Susan Bonner-Weir

Authors
  1. Gordon C. Weir
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  2. Susan Bonner-Weir
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Editors and Affiliations

  1. BioHybrid Technologies, Inc., Shewsbury, Massachusetts, USA

    Robert P. Lanza  & William L. Chick  & 

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© 1996 Kluwer Academic Publishers

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Weir, G.C., Bonner-Weir, S. (1996). Experimental islet transplantation. In: Lanza, R.P., Chick, W.L. (eds) Yearbook of Cell and Tissue Transplantation 1996–1997. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0165-0_14

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  • DOI: https://doi.org/10.1007/978-94-009-0165-0_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6560-3

  • Online ISBN: 978-94-009-0165-0

  • eBook Packages: Springer Book Archive

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