Molecular regulation of plasma and tissue angiotensinogen

  • Peter Eggena
  • Jack D. Barrett

Abstract

In the classical endocrine renin-angiotensin system, circulating angiotensin peptides participate in a number of biologically important processes, including regulation of blood pressure [1], sodium homeostasis [2], production of antidiuretic hormone [3] and modulation of catecholamine release [4]. Complete renin systems, whether originating in part or completely from the circulation or derived from local synthesis, have also been observed in a variety of tissues. Locally generated angiotensin II may regulate a host of additional autocrine, paracrine or intracrine functions. However, in both the circulation and in tissues, angiotensinogen is the sole precursor of these peptide hormones. It is the purpose of this chapter to explore the regulation and functional consequences of angiotensinogen gene expression.

Keywords

High Molecular Weight Form Angiotensinogen Gene Renin System Renin Substrate Angiotensinogen mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Rapid Science Publishers 1996

Authors and Affiliations

  • Peter Eggena
  • Jack D. Barrett

There are no affiliations available

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