Abstract
Using direct current spectrometry, the authors evaluated magnesium concentrations in plasma, erythrocytes and platelets from two groups of subjects who had received a renal transplant and were treated either with cyclosporin, azathioprine and prednisolone or with azathioprine and prednisolone, and in a group of healthy subjects. The plasma, erythrocyte and platelet concentrations of magnesium in the two groups of subjects treated with immunosuppressors were lower than in the control group, while no difference was found between the two groups of transplant recipients for magnesium status. Magnesium fractional excretion was higher in the subjects who had undergone transplantation than in the control group, whereas no difference was found between patients and controls for urinary ion excretion over 24 hours. The depletion of intraplatelet magnesium induced by immunosuppressive drugs may have been responsible for the platelet hyperaggregability found following treatment with cyclosporin and azathioprine.
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Allegra, A. et al. (1997). Platelet, Erythrocyte and Plasma Magnesium Levels in Renal Transplant Recipients During Cyclosporin or Azathioprine Treatment. In: Theophanides, T., Anastassopoulou, J. (eds) Magnesium: Current Status and New Developments. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0057-8_62
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DOI: https://doi.org/10.1007/978-94-009-0057-8_62
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