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Furosemide-Like Natriuretic Actions of Genistein Without Effects on Magnesiuresis

  • I. Gimenez
  • J. M. Lou
  • J. O. Alda
  • J. F. Escanero
Chapter

Abstract

Loop-diuretics, as furosemide, increase magnesiuresis; prolonged treatment with these drugs may cause magnesium deficiency[l]. Magnesium renal reabsorption depends on the work of Na-K-Cl cotransport, which is inhibited by loop diuretics. Magnesium renal reabsorption is modulated also by other factors including aldosterone, parathormone and calcemia. Recently, we reported that isoflavonoids, natural compounds with potential benefits in cancer, cardiovascular diseases or osteoporosis[2] inhibited Na-K-Cl cotransport with a potency only 2–3 times lesser than that of furosemide[3]. Present work was addressed to investigate if genistein, an isoflavonoid, has a magnesiuretic effect like furosemide.

Keywords

Loop Diuretic Magnesium Deficiency Zona Glomerulosa Urinary Excretion Rate Relative Increment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • I. Gimenez
    • 1
  • J. M. Lou
    • 1
  • J. O. Alda
    • 1
  • J. F. Escanero
    • 1
  1. 1.Dpt. of Pharmacology and PhysiologySchool of MedicineZaragozaSpain

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