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A Unique Non-Invasive Intracellular Magnesium Assay Correlating with Cardiac Tissues, Arrhythmias, and Therapeutic Intervention

  • Burton B. Silver
  • Mark C. P. Haigney
  • Steven P. Schulman
  • Gary Gerstenblith
  • Gordon F. Tomaselli
  • Ronald Berger
  • Hugh Calkins
  • Shaokui Wei
Chapter

Abstract

A novel technique using energy dispersive X-ray microanalysis, (EXAtm), for noninvsive intracellular measurement of magnesium has now been accomplished and proven to be a valuable tool in multiple aspects of normal as well as pathological magnesium metabolism (U.S. patent No 4–717–826, B.S.). Over the last 15 years data has accumulated using the unique method which is now available to accurately evaluate tissue Mg levels.

Keywords

Magnesium Deficiency Johns Hopkins Medical Institution Intracellular Magnesium Intracellular Measurement Atrial Biopsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Eisenberg MJ (1992); Magnesium deficiency and sudden death. Am. Heart J. 124: 544–549.CrossRefGoogle Scholar
  2. 2.
    Haigney MCP, Berger R, Calkins H, Silverman HS, Tunin C, Haigney C, Silver B, Gerstenglith G, Schulman S, Tomaselli G (1992): QT dispersion forrelates wtihtissue magnesium concentration in humans. Circ, 86: 1376–1382.Google Scholar
  3. 3.
    Murphy E, Freudenrich CC, Liegerman M. (1991): Cellular magnesium and Na/Mg exchange in heart cells. Ann. Rev. Physiol. 53; 273–287.CrossRefGoogle Scholar
  4. 4.
    Agus ZS, Morad M. (1991) Modulation of cardiac ion channels by magnesium. Ann. Rev. Physiol 299–307.Google Scholar
  5. 5.
    Haigney MCP, Silver B, Tanglao E, Silverman HS, Hill JD, Shapiro JE, Gerstenglith G, Schulman SP (1995): Non-invasive measurement of tissue magnesium and correlation with cardiac levels. Circ. 92; 2190–2197.Google Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Burton B. Silver
    • 1
  • Mark C. P. Haigney
    • 2
  • Steven P. Schulman
    • 3
  • Gary Gerstenblith
    • 3
  • Gordon F. Tomaselli
    • 3
  • Ronald Berger
    • 3
  • Hugh Calkins
    • 3
  • Shaokui Wei
    • 3
  1. 1.Intracellular Diagnostics, Inc.Foster CityUSA
  2. 2.The Department of Medicine, Division of CardiologyUniformed Services University of the Health SciencesBethesdaUSA
  3. 3.The department of Medicin, Division of CardiologyJohns Hopkins Medical InstitutionsBaltimoreUSA

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