Alterations of Serum Magnesium under Chronic Therapy with Diuretics and/or Angiotensin - Converting Enzyme Inhibitors in Hypertensive Patients

  • A. D. Efstratopoulos
  • S. M. Voyaki
  • M. A. Meikopoulos


Diuretic drugs (both thiazide and loop diuretics) have been the mainstay of treatment for arterial hypertension and congestive heart failure [1,3]; however, the prolonged use of thiazide diuretics and (to a lesser extent) of loop-acting diuretics is accompanied by a variable depression of serum and tissue levels of potassium and magnesium and reduced concentrations of sodium-potassium pumps in muscle [4–6]. These diuretic - induced electrolytic disturbances have been associated with cardiac arrhythmias (ventricular ectopic activity [7,8], torsade de pointes [9] and sudden death), especially in elderly patients with hypertension, left ventricular hypertrophy, and/or congestive heart failure [9,10], although in a Editorial Review the cardiotoxicity of diuretics is thought to be the result of “much speculation and little substance” [11].


Congestive Heart Failure Hypertensive Patient Thiazide Diuretic Serum Magnesium Magnesium Deficiency 
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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • A. D. Efstratopoulos
    • 1
  • S. M. Voyaki
    • 1
  • M. A. Meikopoulos
    • 1
  1. 1.Dept. of General Hospital of AthensHypertension Unit & 3rd MedicalAthensGreece

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