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Alterations of Serum Magnesium under Chronic Therapy with Diuretics and/or Angiotensin - Converting Enzyme Inhibitors in Hypertensive Patients

  • A. D. Efstratopoulos
  • S. M. Voyaki
  • M. A. Meikopoulos
Chapter

Abstract

Diuretic drugs (both thiazide and loop diuretics) have been the mainstay of treatment for arterial hypertension and congestive heart failure [1,3]; however, the prolonged use of thiazide diuretics and (to a lesser extent) of loop-acting diuretics is accompanied by a variable depression of serum and tissue levels of potassium and magnesium and reduced concentrations of sodium-potassium pumps in muscle [4–6]. These diuretic - induced electrolytic disturbances have been associated with cardiac arrhythmias (ventricular ectopic activity [7,8], torsade de pointes [9] and sudden death), especially in elderly patients with hypertension, left ventricular hypertrophy, and/or congestive heart failure [9,10], although in a Editorial Review the cardiotoxicity of diuretics is thought to be the result of “much speculation and little substance” [11].

Keywords

Congestive Heart Failure Hypertensive Patient Thiazide Diuretic Serum Magnesium Magnesium Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • A. D. Efstratopoulos
    • 1
  • S. M. Voyaki
    • 1
  • M. A. Meikopoulos
    • 1
  1. 1.Dept. of General Hospital of AthensHypertension Unit & 3rd MedicalAthensGreece

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