Growth Check and Magnesium Imbalance on Young Rats By Over Intakes Of Calcium

  • M. Kimura
  • K. Matumura
  • N. Hatsuda
  • T. Takeda
  • S. Noumi
  • Y. Yokoyama


Osteoporosis in women, that is age-associated bone loss 1) and calcium intake (537 mg/day in average of Japanese) by national nutritional survey less than the current RDA for calcium of 600 mg/day are focused in Japan 2). Therefore recently a significant increase in supply of calcium supplements and the introduction of many kinds of calcium- fortified foods is widely resulted. To Prevent bone loss, public or research attention for increasing of calcium intake was reported 3–5). Effects of low- or high- calcium intakes on zinc balance in humans were also reported 6,7). On the other hand, protein and lipid intakes are increasing with westernized food habits of Japanese 2). In our previous, it was studied that high protein intake with lower calcium intake induced a turn for the worse of osteoporosis 8). Some reports were shown as following that studies using isolated protein sources had shown an increase in urinary calcium excretion and a negative calcium balance in subjects fed a high-protein diet compared with a moderate- protein diet 9), and when phosphate was allowed to rise naturally as the protein intake was increased, no hypercalciuria nor fall in calcium balance was observed 10). Effect of high sodium intake on calcium retention in postmenopausal women was also demonstrated 11,12). But high intake of calcium induced low zinc absorption 13–17). In this report, lesions by over intake of calcium on health and mineral status in rats are studied.


Calcium Intake Magnesium Concentration Prevent Bone Loss Urinary Calcium Excretion Lipid Intake 
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  1. 1.
    Heaney, R.: Nutritional factors in osteoporosis, Annu Trv Nutr 328 (1993), 287–316CrossRefGoogle Scholar
  2. 2.
    National nutritional survey in Japan 1996 (1997)Google Scholar
  3. 3.
    Reid, I.R., Ames, R.W., Evans, M.C., Gamble, G.D., Sharpe, S.J.: Effect Of Calcium Supplementation On Bone Loss In Postmenopausal Women, N Engl J Med 81 (1993), 460–464CrossRefGoogle Scholar
  4. 4.
    awson-Hughes, B.D., Dallal, G., Krall, EA, Sasowski, L., Sahyoun, N., Tannenbaum, S.: A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women, N Engl J Med 323 (1990) 878–883CrossRefGoogle Scholar
  5. 5.
    Aloia, J.F., Vaswani, A., Yeh, J.K, Ross, P.L., Flaster, E., Dilmanian, FA: Calcium supplementation with and without hormone replacement therapy to prevent postmenopausal bone loss, Ann Intrtn Med 120 (1994) 97–10Google Scholar
  6. 6.
    Wood, R.J., Zheng, J. J.: High dietary calcium intakes reduce zinc absorption and balance in humans, Am J Clin Nutr 65 (1997) 1803–1809Google Scholar
  7. 7.
    McKenna, AA, Ilich, J.Z., Andon, M.B., Wang, C., Matkovic, V.: Zinc balance in adolescent females cosuming a low- or high- calcium diet, Am J Clin Nutr 65 (1997) 1460–1464Google Scholar
  8. 8.
    Takeda, T., Kimura, M., Itokawa, Y.: Imbalance of calcium, magnesium and phosphorus in bone and other tissues of rats induced by low protein and calcium deficiency, J Nutr Sci Vitaminol 39 (1993) 355–363CrossRefGoogle Scholar
  9. 9.
    Orwoll, E.S.: The effects of dietary protein insufficiency and excess on skeletal health, Bone 13 (1992) 343–350CrossRefGoogle Scholar
  10. 10.
    Spencer, H., Kramer, L., Osis, D.: Do protein and phosphorus cause calcium loss? J Nutr 118 (1988) 657–560Google Scholar
  11. 11.
    Zarkadas, M., Gougeon-Reyburn, R., Marliss, E.B., Block, E., Alton-Mackey, M.: Sodium chloride supplementation and urinary calcium excretion in postmenopausal women., Am J Clin Nutr 50 (1989)1088–1094Google Scholar
  12. 12.
    Devine, A., Criddle, R.A., Dick, I.M., Prince, R.L.: A longitudial study of the effect of sodium and calcium intakes on regional bone density in postmenopausal women, Am J Clin Nutr 62 (1995) 740–745Google Scholar
  13. 13.
    Forbes, R.M.: Nutritional interactions of zinc and calcium, Am J Clin Nutr 55 (1992) 992–996Google Scholar
  14. 14.
    Hockstra, W.G., Lewis, P.K, Phillips, P.H., Grmmer, R.H.: The relationship of parakeratosis!, suuplemental calcium and zinc to the content of certain body components of swine, J Anim Sci 15 (1956) 572–564Google Scholar
  15. 15.
    Luecke, R.W., Hoeter, JA, Brammell, W.S., Schmidt, DA: Calcium and zinc in parakeratosis! of swine, J Anim Sci 16 (1957) 3–11Google Scholar
  16. 16.
    Dursun, N., Aydogan, S.: Comparative effects of calcium deficiency and supplements on the intestinal absorption of zinc in rats, Jpn J Physiol 44 (1993) 157–166CrossRefGoogle Scholar
  17. 17.
    Argiratos, V., Samman, S.: The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects, Bur J Clin Nutr 45 (1994) 198–204Google Scholar
  18. 18.
    Snedeker, S.M., Smith, S A, Greger, J.L.: Effect of dietary calcium and phosphorus levels on the utilization of iron, copper, and zinc by adult males, J Nutr 112 (1982) 136–143Google Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • M. Kimura
    • 1
  • K. Matumura
    • 1
  • N. Hatsuda
    • 1
  • T. Takeda
    • 1
  • S. Noumi
    • 2
  • Y. Yokoyama
    • 2
  1. 1.Department of Social & Preventive MedicineGraduate School of Medicine Kyoto UniversityKyotoJapan
  2. 2.Akou Chemical Co. LtdAkouJapan

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