Growth Check and Magnesium Imbalance on Young Rats By Over Intakes Of Calcium
Osteoporosis in women, that is age-associated bone loss 1) and calcium intake (537 mg/day in average of Japanese) by national nutritional survey less than the current RDA for calcium of 600 mg/day are focused in Japan 2). Therefore recently a significant increase in supply of calcium supplements and the introduction of many kinds of calcium- fortified foods is widely resulted. To Prevent bone loss, public or research attention for increasing of calcium intake was reported 3–5). Effects of low- or high- calcium intakes on zinc balance in humans were also reported 6,7). On the other hand, protein and lipid intakes are increasing with westernized food habits of Japanese 2). In our previous, it was studied that high protein intake with lower calcium intake induced a turn for the worse of osteoporosis 8). Some reports were shown as following that studies using isolated protein sources had shown an increase in urinary calcium excretion and a negative calcium balance in subjects fed a high-protein diet compared with a moderate- protein diet 9), and when phosphate was allowed to rise naturally as the protein intake was increased, no hypercalciuria nor fall in calcium balance was observed 10). Effect of high sodium intake on calcium retention in postmenopausal women was also demonstrated 11,12). But high intake of calcium induced low zinc absorption 13–17). In this report, lesions by over intake of calcium on health and mineral status in rats are studied.
KeywordsCalcium Intake Magnesium Concentration Prevent Bone Loss Urinary Calcium Excretion Lipid Intake
Unable to display preview. Download preview PDF.
- 2.National nutritional survey in Japan 1996 (1997)Google Scholar
- 5.Aloia, J.F., Vaswani, A., Yeh, J.K, Ross, P.L., Flaster, E., Dilmanian, FA: Calcium supplementation with and without hormone replacement therapy to prevent postmenopausal bone loss, Ann Intrtn Med 120 (1994) 97–10Google Scholar
- 6.Wood, R.J., Zheng, J. J.: High dietary calcium intakes reduce zinc absorption and balance in humans, Am J Clin Nutr 65 (1997) 1803–1809Google Scholar
- 7.McKenna, AA, Ilich, J.Z., Andon, M.B., Wang, C., Matkovic, V.: Zinc balance in adolescent females cosuming a low- or high- calcium diet, Am J Clin Nutr 65 (1997) 1460–1464Google Scholar
- 10.Spencer, H., Kramer, L., Osis, D.: Do protein and phosphorus cause calcium loss? J Nutr 118 (1988) 657–560Google Scholar
- 11.Zarkadas, M., Gougeon-Reyburn, R., Marliss, E.B., Block, E., Alton-Mackey, M.: Sodium chloride supplementation and urinary calcium excretion in postmenopausal women., Am J Clin Nutr 50 (1989)1088–1094Google Scholar
- 12.Devine, A., Criddle, R.A., Dick, I.M., Prince, R.L.: A longitudial study of the effect of sodium and calcium intakes on regional bone density in postmenopausal women, Am J Clin Nutr 62 (1995) 740–745Google Scholar
- 13.Forbes, R.M.: Nutritional interactions of zinc and calcium, Am J Clin Nutr 55 (1992) 992–996Google Scholar
- 14.Hockstra, W.G., Lewis, P.K, Phillips, P.H., Grmmer, R.H.: The relationship of parakeratosis!, suuplemental calcium and zinc to the content of certain body components of swine, J Anim Sci 15 (1956) 572–564Google Scholar
- 15.Luecke, R.W., Hoeter, JA, Brammell, W.S., Schmidt, DA: Calcium and zinc in parakeratosis! of swine, J Anim Sci 16 (1957) 3–11Google Scholar
- 17.Argiratos, V., Samman, S.: The effect of calcium carbonate and calcium citrate on the absorption of zinc in healthy female subjects, Bur J Clin Nutr 45 (1994) 198–204Google Scholar
- 18.Snedeker, S.M., Smith, S A, Greger, J.L.: Effect of dietary calcium and phosphorus levels on the utilization of iron, copper, and zinc by adult males, J Nutr 112 (1982) 136–143Google Scholar