Atherogenic Lipid Fractions are Related to Free Magnesium Ion Status

  • A. Haenni
  • M. Öhrwall
  • H. Lithell


Magnesium deficiency in experimental animals has been found to cause adverse alterations in the blood lipid composition [1,2] and to affect lipid infiltration into the endothelium [3], Diets supplemented with magnesium, on the other hand, have been shown to prevent the development of atherosclerosis by inhibiting lipid accumulation in the aortic wall [4]. In spite of this pattern consistent correlations have not been demonstrated between magnesium and lipid concentrations [5]. It has been questioned whether the total magnesium concentration in the blood reflects the biological activity of magnesium, since only about 60% of the magnesium in the blood is in a free, unbound state, as determined by indirect methods. More than 30% of the total serum magnesium is bound to proteins, mainly albumin, and the remaining 10% is bound to phosphate, citrate, and other substances [6]. It has now become possible, by use of electrodes sensitive to ionized magnesium, to assess the concentration of free magnesium ions in the blood [7]. The aim of the present study was to investigate the associations between variables reflecting lipid metabolism, on the one hand, and the free ion status and total magnesium concentration in the blood, on the other hand.


Magnesium Concentration Magnesium Deficiency Serum Magnesium Concentration Free Magnesium Total Magnesium 
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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • A. Haenni
    • 1
  • M. Öhrwall
    • 1
  • H. Lithell
    • 1
  1. 1.Dept of GeriatricsUppsala UniversityUppsalaSweden

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