Atherogenic Lipid Fractions are Related to Free Magnesium Ion Status

  • A. Haenni
  • M. Öhrwall
  • H. Lithell
Chapter

Abstract

Magnesium deficiency in experimental animals has been found to cause adverse alterations in the blood lipid composition [1,2] and to affect lipid infiltration into the endothelium [3], Diets supplemented with magnesium, on the other hand, have been shown to prevent the development of atherosclerosis by inhibiting lipid accumulation in the aortic wall [4]. In spite of this pattern consistent correlations have not been demonstrated between magnesium and lipid concentrations [5]. It has been questioned whether the total magnesium concentration in the blood reflects the biological activity of magnesium, since only about 60% of the magnesium in the blood is in a free, unbound state, as determined by indirect methods. More than 30% of the total serum magnesium is bound to proteins, mainly albumin, and the remaining 10% is bound to phosphate, citrate, and other substances [6]. It has now become possible, by use of electrodes sensitive to ionized magnesium, to assess the concentration of free magnesium ions in the blood [7]. The aim of the present study was to investigate the associations between variables reflecting lipid metabolism, on the one hand, and the free ion status and total magnesium concentration in the blood, on the other hand.

Keywords

Magnesium Concentration Magnesium Deficiency Serum Magnesium Concentration Free Magnesium Total Magnesium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rayssiguier, Y.: Magnesium, lipids and vascular diseases. Magnesium 5(1986),182–190Google Scholar
  2. 2.
    Gueux, E., Cubizolles, C., Bussiere, L., Mazur, A., Rayssiguier, Y.: Oxidative modification of triglyceride-rich lipoproteins in hypertriglyceridemic rats following magnesium deficiency. Lipids 28(1993): 573–5CrossRefGoogle Scholar
  3. 3.
    Yokoyama, S., Gu, J., Kashima, K., Nishida, H.I., Smith, T.L., Kummerov, F.A.: Combined effects of magnesium deficiency and the atherogenic level of low density lipoprotein on uptake and metabolism of low density lipoprotein by cultured human endothelial cells. Magnes Res 7(1994): 97–105Google Scholar
  4. 4.
    Ouchi, Y., Tabata, R., Stergiopoulos, K., Sato, F., Hattori, A., Orimo, H.: Effect of dietary magnesium on development of atherosclerosis in cholesterol-fed rabbits. Arteriosclerosis 10(1990): 732–737CrossRefGoogle Scholar
  5. 5.
    Speich, M., Gelot, S., Auget, J.: Pasma and erytrocyte magnesium, calcium, zinc, copper, phosphorus and cholesterols in a population of 1050 healthy adults. Mag-Bull 17(1995): 62–69Google Scholar
  6. 6.
    Walser, M.: Magnesium metabolism. Rev Physiol Biochem Exp Pharmacol 59(1967): 185–341Google Scholar
  7. 7.
    Maj-Zurawska, M., Lewenstam, A.: Fully automated Potentiometrie determination of ionised magnesium in blood serum. Analytica Chimica Acta, 236(1990): 331–335CrossRefGoogle Scholar
  8. 8.
    KONE: Users Manual to KONE Microlyte with Magnesium. Helsinki, Finland, 1993Google Scholar
  9. 9.
    Ising, H., Bertschat, F., Günther, T., Jeremias, E., Jeremias, A.: Measurement of free magnesium in blood, serum and plasma with an ion-selective electrode. Eur J Clin Chem Clin Biochem 33(1995): 365–71Google Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • A. Haenni
    • 1
  • M. Öhrwall
    • 1
  • H. Lithell
    • 1
  1. 1.Dept of GeriatricsUppsala UniversityUppsalaSweden

Personalised recommendations