Changes of Magnesium Concentrations in Rat Tissues After the Administration of Drugs Used in Hypertension Therapy

  • V. P. Kotsaki-Kovatsi
  • E. Bacoyanni
  • G. Koeiiler-Samouilidou
  • A. Vafiadou
  • A. N. Kovatsis
Chapter

Abstract

The importance of the presence of the trace elements and their physiological distribution in the organism as well as the appearance of symptoms related to their redistribution and/or elimination are well known. Some drugs have the ability to form complexes with metal ions in vitro and we believe that the same happens in vivo. We also believe that through that mechanism they mobilize the essential for the normal function of the organism trace elements, and the result is their redistribution and elimination from the organism.[1,2,3]. It is therefore important to know how the administration of drugs and specially those which are administered chronically affects the concentrations of essential trace metals in biological systems.

Keywords

Diabetes Insipidus Magnesium Concentration Ocular Tissue Flame Atomic Absorption Spectrophotometry Essential Hypertensive Patient 
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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • V. P. Kotsaki-Kovatsi
    • 1
  • E. Bacoyanni
    • 2
  • G. Koeiiler-Samouilidou
    • 2
  • A. Vafiadou
    • 2
  • A. N. Kovatsis
    • 2
  1. 1.Lab. of Pharmacology, Faculty ofVeterinary MedicineAristotle UniversityMacedonia, ThessalonikiGreece
  2. 2.Lab. of Biochemistry and ToxicologyAristotle UniversityMacedonia, ThessalonikiGreece

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