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Influence of Four Non-Steroid Anti-Inflammatory Drugs (Naproxen, Tolmetin, Tolfenamic Acid and Voltaren) and One Antibiotic (Monensin) on Magnesium Concentrations in Guinea Pig or Rat Tissues

  • V.-P. Kotsaki-Kovatsi
Chapter

Abstract

In the present study, the effect of the administration of naproxen, tolmetin, tolfenamic acid and voltaren (non-steroid anti-inflammatory drugs) as well as monensin (antibiotic) on the magnesium concentration in guinea pig or rat tissues, was studied. Naproxen significantly decreased the magnesium concentration in the spleen and heart of the treated guinea pigs. Although tolmetin increased the magnesium concentration in some tissues of guinea pigs (brain, heart, lung, kidney, adrenals and testis) and decreased it in some others (spleen and thigh bone), the changes were not statistically significant. Spleen, ovaries and bone magnesium concentrations were increased in guinea pigs fed tolfenamice acid Voltaren significantly decreased the magnesium concentration in the heart, liver, kidney and testis and increased it in the spleen of guinea pigs. Monensin significantly decreased the magnesium concentration in the brain, heart, lung, spleen and testis of rats and increased it in the thigh bone.

Keywords

Magnesium Concentration Chemical Point Tolfenamic Acid Thigh Bone Normal Heart Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • V.-P. Kotsaki-Kovatsi
    • 1
  1. 1.Laboratory of Pharmacology, Faculty of Veterinary MedicineAristotle UniversityMacedonia, ThessalonikiGreece

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