Influence of Four Non-Steroid Anti-Inflammatory Drugs (Naproxen, Tolmetin, Tolfenamic Acid and Voltaren) and One Antibiotic (Monensin) on Magnesium Concentrations in Guinea Pig or Rat Tissues

  • V.-P. Kotsaki-Kovatsi


In the present study, the effect of the administration of naproxen, tolmetin, tolfenamic acid and voltaren (non-steroid anti-inflammatory drugs) as well as monensin (antibiotic) on the magnesium concentration in guinea pig or rat tissues, was studied. Naproxen significantly decreased the magnesium concentration in the spleen and heart of the treated guinea pigs. Although tolmetin increased the magnesium concentration in some tissues of guinea pigs (brain, heart, lung, kidney, adrenals and testis) and decreased it in some others (spleen and thigh bone), the changes were not statistically significant. Spleen, ovaries and bone magnesium concentrations were increased in guinea pigs fed tolfenamice acid Voltaren significantly decreased the magnesium concentration in the heart, liver, kidney and testis and increased it in the spleen of guinea pigs. Monensin significantly decreased the magnesium concentration in the brain, heart, lung, spleen and testis of rats and increased it in the thigh bone.


Magnesium Concentration Chemical Point Tolfenamic Acid Thigh Bone Normal Heart Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Cantilena L.R. and E.D. Klaasen (1982). The effect of chelating agents on the excretion of endogenous metals. Toxicol. Appl Pharmacol, 63,344–350.CrossRefGoogle Scholar
  2. Chebowski J.F. and J.E. Coleman (1976). Zinc and its role in enzymes. In chart of metal ions in biological systems.H. Sigel, Marcel Dekker Inc., N.Y. 6,118Google Scholar
  3. Dendrinou-Samara E., D. Kessisoglou, G. Manoussakis, D. Mentzafos and A. Terzis (1990). Copper (II) complexes with anti-inflammatory drugs as ligands. Molecular and crystal structure of bis (dimethyl sulphoxide) tetrakis (6-methoxy-a-methyl-2-naphthaleneacetate dicopper (II) and bis (dimethyl sulphoxide) tetrakis [1-met yl- 5-(p-toluoyl)- H-pyrrole- 2aeitato) dicopper (II). Journal of the Chemical Society. Dalton Transactions, 1, 959–965Google Scholar
  4. Green L.W., G.T. Schelling and F.M Byers (1986). Effects of dietary monensin and potassium on apparent absorption of magnesium and other macroelements in sheep. J. Anim. Sci.,63,1960Google Scholar
  5. Greene L.W., B.J May, G.T. Schelling and F.M. Byers (1988). Site and extent of apparent magnesium and calcium absorption in steers fed monensin. J. Anim. Sci.,66,2987Google Scholar
  6. Gunter T. (1981). Biochemistry andpathobiochemistry of magnesium. Magn. Bull.,3–1,91–101Google Scholar
  7. Hamilton Smith C., and W.R. Bidlack (1980). Interrelationship of dietary ascorbic acid and iron on the tissue distribution of ascorbic acid, iron and copper in female guinea pigs. J. Nutr. 110,1398–1408Google Scholar
  8. Kotsaki-Kovatsi V-P, A. Kovatsis, G. Rozos, A. Vafiadou and G. Batzias (1992). Effects of monensin on zinc, copper, magnesium and calcium tissue concentrations in rats. Proceedings of the 30th TIAFT international meeting in Fukuoka, JapanGoogle Scholar
  9. Kotsaki-Kovatsi, V -P., G. Batzias, G. Rozos, and A. Kovatsis (1993a). Influence of naproxen on the concentration of iron, potassium and sodium in guinea pig tissues. Bulletin of the Hellenic Veterinary Medical Society. 44,19–22Google Scholar
  10. Kotsaki-Kovatsi, V.-P., E. Alexaki-Tzivanidou, G. Batzias, G. Rozos, and A Kovatsis (1993b). Influence of naproxen on the zinc, copper magnesium and calcium content of guinea pig tissues. J. Vet. Med. A 40,555–58Google Scholar
  11. Kotsaki Kovatsi, V.P., A. Kovatsis, A. Dega, S. Tzika and G. Rozos (1993 c). Influence of voltaren on metal ion distribution in guinea pig tissues. Proceedings of 8th Medical Congress of Northern Greece, Thessaloniki, GreeceGoogle Scholar
  12. Kotsaki Kovatsi, V.P., G. Rozos, G. Batzias, A. Vafiadou and A. Kovatsis (1994a). Influence oftolmetin on the zinc, copper and magnesium content of guinea pig tissues. J. Vet Pharmacol. Therap. 17,396–398CrossRefGoogle Scholar
  13. Kotsaki Kovatsi, V P., A. Kovatsis, G. Rozos, and G. Samouilidou Keller (1994 b). Influence of tolfenamic acid on metal ion distribution in guinea pig tissues. Presented at Tiaft-Soft Congress in Tampa, Florida, USA.Google Scholar
  14. Langer, P. (1972). Carier mediated ion transport. Science, 179,24Google Scholar
  15. Ovchinnikov Y.A. (1979). Physico-chemical basis of ion transport through biological membranes. Ionophores and ion channels. European J. Biochem., 94, 321CrossRefGoogle Scholar
  16. Pressman B.C, (1973). Properties of ionophores with a broad range of cation selectivity. Fed. Proc. 32, 1696Google Scholar
  17. Rao C.M., K.V. Ramesh, K.L. Bairy and D.R. Kullkami (1990). Comparative evaluation oftolmetin and tolmetin zinc on wound repair and inflammation. Indian Journal of Medical Research. 92,205–208.Google Scholar
  18. Rossowska M.J., C. Dinh, S.B. Gottsdialk, M. Yazddani, F.S. Sutton and T. Nakamoto (1990). Interaction between caffeine intake and heart zinc concentrations in the rats. British Journal of Nutrition. 64, 561–567.CrossRefGoogle Scholar
  19. Southern, L.L. and D. H Baker (1982). Eimeria aoervulina infection in chicks fed excess dietary methionine. J. Anim. Sci. 54,989.Google Scholar
  20. Touyz, R. M., Milne, F.J. and Reinach, S. G. [1992]: Platelet and erythrocyte Mg 2+, Ca2+, Na K + and cell membrane adenosine triphosphate activity in essential hypertension in blacks. J. Hypertens.. 10,571–578CrossRefGoogle Scholar
  21. Risco, F. and Traba, M. C. [1994]: Possible involvement of a magpesium dependent mitochondrial alkaline phosphatase in the regulation ot the 254iydroxyvitamm D3-la- and 25-hydroxyvitamin D3–24R- hydroxylases in LLC-PK1 cells. Magnes. Res. 7,169–178Google Scholar
  22. Durlach, J. [1988]: In: Magnesium in clinical practice, pp. 9–10. London: John LibbeyGoogle Scholar
  23. Dhalla, N. S. and Zhao, D. [1989]: Possible role of sarcolemmal Ca 2+/Mg 2+, ATPase in heart function. Magnes. Res. 2, 161–172Google Scholar
  24. Wacker, W. E. C. [1969]: The biochemistry of magnesium. Ann. N. Y. Acad. Sci. 162, 717CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • V.-P. Kotsaki-Kovatsi
    • 1
  1. 1.Laboratory of Pharmacology, Faculty of Veterinary MedicineAristotle UniversityMacedonia, ThessalonikiGreece

Personalised recommendations