Synthesis and NMR Spectroscopic Studies of a New Magnesium Antibiotic Compound

  • Margarita Petroliagi
  • Olga Markopoulou
  • John Markopoulos


The combinatorial approach to drug discovery has led to focus on heterocyclic nitrogen frameworks enjoying a splendid therapeutic record. A special branch of such compounds is the 3-alkanoyl-5-arylidene tetramic acids, pyrrolidine-2, 4-diones. These natural products possessing an enolic β,β’-tricarbonyl moiety, a hydrophobic 5-substituent and a lipophilic 3-alkanoyl-substituent, are interest complexation hosts for various metal ions such as Mg (II), Pt (II) [1]. Their biological activity is related to their complexation properties and the mechanisms responsible for it is affected by the polarity of these complexes to transport through cell boundary.


Cell Boundary Complexation Property Combinatorial Approach Special Branch Magnesium Atom 
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  1. 1.
    Matsunaga, K., Hasegawa, S., and Muto, M., Jpn. Pat. 01/313,488 [CA 113, 51507 (1990)]; Hasegawa, S., Matsunaga, K., and Muto, M., Jpn. Pat. 02/48,591 [CA 114, 16607 (1991)].Google Scholar
  2. 2.
    Imamura, N., Adachi, K., and Sano, H. (1994) J. Antibiotics, 47(2), 257–261; Bhat, S.V., Kohl, H., Ganguli, B.N., and DE Souza, N.J. (1977) Eur. J. Med. Chem. Chimica Therapeutics 12(1), 53–57; Hoechst A.G., Brit. 1,478,643 [CA 88, 168480 (1978)].Google Scholar
  3. 3.
    Markopoulou, O., Markopoulos, J., and Nicholls, D. (1990) J. Inorg. Biochem., 39, 307–316; Heaton, B.T., Jacob, C., Markopoulos, J., Markopolou, O., Nahring, J., Skylaris, C.-K., and Smith, A.K. (1996) J. Chem. Soc., Dalton Trans, 1701–1706.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Margarita Petroliagi
    • 1
  • Olga Markopoulou
    • 1
  • John Markopoulos
    • 2
  1. 1.Organic Chemistry LaboratoryNational Technical University of AthensGreece
  2. 2.Inorganic Chemistry LaboratoryUniversity of AthensGreece

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